172,143 research outputs found

    Bellis medio, Bellis minore, Bellis maggiore, Clematide seconda, Vinca per vinca

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    1-2. Nome scientifico: Bellis perennis L. (Asteraceae, Compositae) Nome attuale: Pratolina 3. Nome scientifico: Leucanthemum vulgare Lam. (Asteraceae, Compositae) Nome attuale: Margherita 4-5. Nome scientifico: Vinca minor L. (Apocinaceae) Nome attuale: Pervinc

    PCSK9 Inhibitors: Is the Time Ripe for the “Fast Track” Use Independently on the LDL-C Baseline Values in Acute Coronary Syndrome?

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    : The low-density lipoprotein cholesterol (LDL-C) lowering decreases the risk to develop major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS). Therefore, the "fast track" use of PCSK9 inhibitors (PCSK9i) has been introduced in ACS patients not achieving LDL-C target (70 mg/dl) despite an ongoing lipid lowering therapy with statin at maximum tolerated dosage plus ezetimibe or stain-naïve (LDL-C > 130 mg/dl). PCSK9i "fast track" use has shown to achieve the regression of "non-culprit" atherosclerotic plaques leading to a further MACE decrease. Interestingly, it has been also hypothesized a role of PCSK9i beyond the LDL-C lowering in ACS. PCSK9i have been demonstrated to decrease the inflammation of atherosclerotic plaques and myocardium, inhibit platelet aggregation, and improve the cardiomyocyte survival against the reperfusion injury. All these findings may positively impact on the prognosis and suggest the PCSK9i use in the acute phase of ACS independently on the baseline LDL-C values

    FIGURES 39–44 in Marksomyia, a new subgenus of Culicoides Latreille (Diptera: Ceratopogonidae) from the Australasian biogeographic region with descriptions of two new species

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    FIGURES 39–44. Antennae of male Culicoides (Marksomyia) species. Plume aristae are not shown although attachment bases are indicated where present. 39. C. marksi Lee & Reye. 40. C. pseudostigmaticus Tokunaga. 41. C. zentae Bellis & Dyce sp. nov. 42. C. kayi Bellis & Dyce sp. nov. 43. C. parvimaculatus Lee & Reye. 44. C. dycei Lee & Reye.Published as part of Bellis, Glenn & Dyce, Alan, 2011, Marksomyia, a new subgenus of Culicoides Latreille (Diptera: Ceratopogonidae) from the Australasian biogeographic region with descriptions of two new species, pp. 35-38 in Zootaxa 3014 on page 46, DOI: 10.5281/zenodo.20442

    Culicoides kayi Bellis & Dyce, sp. nov.

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    <i>Culicoides kayi</i> Bellis & Dyce sp. nov. <p>(Figs 4, 10, 16, 22, 29, 36, 42, 48, 54)</p> <p> <b>Type material examined.</b> Holotype <b>Australia, WA,</b> Collie-Darkam Rd, trucktrap, 1910–1940 hr, 29.x.1985, A.L. Dyce (female, ANIC). <b>Paratypes</b>, same data as holotype (8 females, 2 males ANIC); Collie-Darkam Rd, trucktrap, 1840–1910 hr, 29.x.1985, A.L. Dyce & W.W. Wirth (2 males ANIC); Young R, 13km N by W Shoalcape, 20– 21.ix.1981, I.D. Naumann & J.C. Cardale, (1 female ANIC); 19km SSW of Grass Patch, 19–20.ix.1981, I.D. Naumann & J.C. Cardale (1 female ANIC).</p> <p> <b>Diagnosis.</b> Wing with 2 pale spots in cell M4, anterior spot rounded or triangular. Female with SCo distribution 3,(8–9),10–15, six to seven SCh on 4–10, two to three on 11–15; spermathecae with unsclerotised, pear-shaped body and short, sclerotised neck. Male with SCo distribution 3, (9),13–15; STl distribution 3–6 (7); STc distribution 4–7,(8–9); about seven SCh on 14; apical half of parameres strongly curved laterad, ventral membrane of ninth sternite with spicules present laterally, medially bare.</p> <p> <b>Female. Head.</b> Eyes bare, separated by a distance of less than one facet (Fig 4), proboscis short. Palpus (fig 10) brown with five segments, segment 3 expanding apically then abruptly narrowed beyond a moderately shallow round pit with protruding capitate sensilla. Antennomeres (fig 16) 4–10 barrel shaped, 11–15 cylindrical, short.</p> <p> <b>Thorax.</b> Legs (fig 22) dark brown with dark knees, fore and mid femora pale basally and with conspicuous pale subapical band; hind femur with apical pale band less conspicuous; all tibiae with conspicuous pale sub-basal band and diffusely pale subapically. Wing (fig 29) strongly patterned with two ovoid pale spots in cell M4.</p> <p> <b>Abdomen.</b> Three developed, pear-shaped spermathecae, body unsclerotised and difficult to see in most specimens but necks strongly sclerotised and conspicuous, (fig 36). Ducts short, about as long as spermathecae; sclerotised ring usually tapered.</p> <p> <b>Male. Head.</b> Eyes bare. Palpus similar to female with shallow pit on segment 3. Antenna (Fig 42) with single row of plume verticils on antennomeres 3–12; antennomeres 13–15 elongate subcylindrical and narrow.</p> <p> <b>Genitalia.</b> (fig 48) Ninth tergite with caudal margin flat to slightly convex. Ninth sternite with deep, U-shaped caudomedial excavation, ventral membrane with a narrow anterior band of spicules interrupted medially by a narrow bare area. Gonocoxite short and broad, longer than wide, dorsal root long; ventral root moderately long, simple and pointed. Gonostylus slender, distally curving gently to a pointed apex. Aedeagus with distal process short with a slight apical rounded expansion. Parameres separate, with straight basal arms angled sharply to weakly swollen stem, narrowing gradually to simple sharp-tipped distal portion curved lateroventrad.</p> <p> <b>Immatures.</b> Unknown.</p> <p> <b>Distribution.</b> Known only from the south of WA.</p> <p> <b>Biology.</b> Unknown. Label data suggests crepuscular adult activity.</p> <p> <b>Etymology.</b> Named for Dr. Brian Kay in appreciation of his long term collaboration with field studies of midge biology.</p> <p> <b>Remarks.</b> This species is very similar to <i>C. parvimaculatus</i> and can be distinguished from other species in <i>Marksomyia</i> by the same combination of characters as discussed for <i>C. parvimaculatus</i>. Males can be distinguished from <i>C. parvimaculatus</i> by the straight bases to the parameres which contrast to the curved bases in <i>C. parvimaculatus</i>. Females can be distinguished from <i>C. parvimaculatus</i> and <i>C. zentae</i> by the presence of SCo on segment 10. The wing of this species was illustrated by Dyce et al (2007) under the name Marksi gp sp no 2.</p>Published as part of <i>Bellis, Glenn & Dyce, Alan, 2011, Marksomyia, a new subgenus of Culicoides Latreille (Diptera: Ceratopogonidae) from the Australasian biogeographic region with descriptions of two new species, pp. 35-38 in Zootaxa 3014</i> on pages 46-47, DOI: <a href="http://zenodo.org/record/204428">10.5281/zenodo.204428</a&gt

    Redescription of the adults of Culicoides bancrofti Lee and Reye and C. hornsbyensis Lee and Reye (Diptera: Ceratopogonidae)

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    Bellis, Glenn, Dyce, Alan (2012): Redescription of the adults of Culicoides bancrofti Lee and Reye and C. hornsbyensis Lee and Reye (Diptera: Ceratopogonidae). Zootaxa 3566: 51-60, DOI: 10.5281/zenodo.21127

    Culicoides kayi Bellis & Dyce, sp. nov.

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    <i>Culicoides kayi</i> Bellis & Dyce sp. nov. <p>(Figs 4, 10, 16, 22, 29, 36, 42, 48, 54)</p> <p> <b>Type material examined.</b> Holotype <b>Australia, WA,</b> Collie-Darkam Rd, trucktrap, 1910–1940 hr, 29.x.1985, A.L. Dyce (female, ANIC). <b>Paratypes</b>, same data as holotype (8 females, 2 males ANIC); Collie-Darkam Rd, trucktrap, 1840–1910 hr, 29.x.1985, A.L. Dyce & W.W. Wirth (2 males ANIC); Young R, 13km N by W Shoalcape, 20– 21.ix.1981, I.D. Naumann & J.C. Cardale, (1 female ANIC); 19km SSW of Grass Patch, 19–20.ix.1981, I.D. Naumann & J.C. Cardale (1 female ANIC).</p> <p> <b>Diagnosis.</b> Wing with 2 pale spots in cell M4, anterior spot rounded or triangular. Female with SCo distribution 3,(8–9),10–15, six to seven SCh on 4–10, two to three on 11–15; spermathecae with unsclerotised, pear-shaped body and short, sclerotised neck. Male with SCo distribution 3, (9),13–15; STl distribution 3–6 (7); STc distribution 4–7,(8–9); about seven SCh on 14; apical half of parameres strongly curved laterad, ventral membrane of ninth sternite with spicules present laterally, medially bare.</p> <p> <b>Female. Head.</b> Eyes bare, separated by a distance of less than one facet (Fig 4), proboscis short. Palpus (fig 10) brown with five segments, segment 3 expanding apically then abruptly narrowed beyond a moderately shallow round pit with protruding capitate sensilla. Antennomeres (fig 16) 4–10 barrel shaped, 11–15 cylindrical, short.</p> <p> <b>Thorax.</b> Legs (fig 22) dark brown with dark knees, fore and mid femora pale basally and with conspicuous pale subapical band; hind femur with apical pale band less conspicuous; all tibiae with conspicuous pale sub-basal band and diffusely pale subapically. Wing (fig 29) strongly patterned with two ovoid pale spots in cell M4.</p> <p> <b>Abdomen.</b> Three developed, pear-shaped spermathecae, body unsclerotised and difficult to see in most specimens but necks strongly sclerotised and conspicuous, (fig 36). Ducts short, about as long as spermathecae; sclerotised ring usually tapered.</p> <p> <b>Male. Head.</b> Eyes bare. Palpus similar to female with shallow pit on segment 3. Antenna (Fig 42) with single row of plume verticils on antennomeres 3–12; antennomeres 13–15 elongate subcylindrical and narrow.</p> <p> <b>Genitalia.</b> (fig 48) Ninth tergite with caudal margin flat to slightly convex. Ninth sternite with deep, U-shaped caudomedial excavation, ventral membrane with a narrow anterior band of spicules interrupted medially by a narrow bare area. Gonocoxite short and broad, longer than wide, dorsal root long; ventral root moderately long, simple and pointed. Gonostylus slender, distally curving gently to a pointed apex. Aedeagus with distal process short with a slight apical rounded expansion. Parameres separate, with straight basal arms angled sharply to weakly swollen stem, narrowing gradually to simple sharp-tipped distal portion curved lateroventrad.</p> <p> <b>Immatures.</b> Unknown.</p> <p> <b>Distribution.</b> Known only from the south of WA.</p> <p> <b>Biology.</b> Unknown. Label data suggests crepuscular adult activity.</p> <p> <b>Etymology.</b> Named for Dr. Brian Kay in appreciation of his long term collaboration with field studies of midge biology.</p> <p> <b>Remarks.</b> This species is very similar to <i>C. parvimaculatus</i> and can be distinguished from other species in <i>Marksomyia</i> by the same combination of characters as discussed for <i>C. parvimaculatus</i>. Males can be distinguished from <i>C. parvimaculatus</i> by the straight bases to the parameres which contrast to the curved bases in <i>C. parvimaculatus</i>. Females can be distinguished from <i>C. parvimaculatus</i> and <i>C. zentae</i> by the presence of SCo on segment 10. The wing of this species was illustrated by Dyce et al (2007) under the name Marksi gp sp no 2.</p>Published as part of <i>Bellis, Glenn & Dyce, Alan, 2011, Marksomyia, a new subgenus of Culicoides Latreille (Diptera: Ceratopogonidae) from the Australasian biogeographic region with descriptions of two new species, pp. 35-38 in Zootaxa 3014</i> on pages 46-47, DOI: <a href="http://zenodo.org/record/204428">10.5281/zenodo.204428</a&gt

    Pond's extract, the vegetable pain destroyer

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    This apothecary card for Pond's Extract displays an illustration of a young boy riding a pony while the dog follows, carrying a basket of flowers. “J.M. Bellis & Son, Druggists, Flemington, NJ,” stamped on the back. Circa 1870 through 1920

    Triterpenoid saponins of Bellis perennis

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    Ten saponins have been isolated from the deacylated saponin mixture of Bellis perennis L. The structures of these saponins can be divided into two groups that show differences both in the aglycone and the carbohydrate moieties bound at C-28. The first group consists of glycosides of polygalacic acid with tri- or tetrasaccharide moieties consisting mainly of deoxyhexoses and a second group of glycosides of bayogenin or asterogenic acid which possess glucose as major carbohydrate moiety and one xylose or rharnnose unit. From the most polar fraction of the alkaline hydrolysate obtained from the underground parts of Bellis perennis one saponin possessing only glucose residues has been obtained. On the basis of a sugar methylation analysis and NMR spectral data, the structure was established as 3-O-ß-D-glucopyranosyl-2ß,3ß,23-trihydroxyolean-12-en-28-oic acid 28-O-ß-D-glucoyranosyl-(1→2)-[ß-D-glucopyranosyl(1→6)]-ß-D-glucopyranoside

    FIGURES 11–21. Culicoides Bancrofti group species. C in Redescription of the adults of Culicoides bancrofti Lee and Reye and C. hornsbyensis Lee and Reye (Diptera: Ceratopogonidae)

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    FIGURES 11–21. Culicoides Bancrofti group species. C. bancrofti Lee & Reye, 11, female antenna; 13, female flagellomere 6; 14, male antenna; 16, 17 spermathecae; 18, tibial comb; 20, mandibular teeth. C. hornsbyensis Lee & Reye, 12, female antenna; 15, male antenna; 17, spermathecae; 19, tibial comb; 21 mandibular teeth.Published as part of Bellis, Glenn & Dyce, Alan, 2012, Redescription of the adults of Culicoides bancrofti Lee and Reye and C. hornsbyensis Lee and Reye (Diptera: Ceratopogonidae), pp. 51-60 in Zootaxa 3566 on page 57, DOI: 10.5281/zenodo.21127

    Pond's extract, vegetable pain destroyer

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    This apothecary card for Pond's Extract displays an illustration of a sick dog with an open bottle of Pond's extract in one picture and the next picture he is healed. “J.M. Bellis & Son, Druggists, Flemington, NJ,” stamped on the back. Circa 1870 through 1920
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