1,721,014 research outputs found
Pan-Cancer Upregulation of the FOXM1 Transcription Factor
No full textBackground: The human FOXM1 transcription factor controls cell cycle progression and genome stability, and it has been correlated to the onset and progression of many tumor types. Methods: In our study, we collected all recent sequence and quantitative transcriptomics data about FOXM1, testing its presence across vertebrate evolution and its upregulation in cancer, both in bulk tissue contexts (by comparing the TCGA tumor dataset and the GTEx normal tissue dataset) and in single-cell contexts. Results: FOXM1 is significantly and consistently upregulated in all tested tumor types, as well as in tumor cells within a cancer microenvironment. Its upregulation reverberates in the upregulation of its target genes and can be used as a biomarker for poor cancer outcome in at least four tumor types. Conclusions: Despite its lack of cancer-related mutations and amplifications, the recurring upregulation of FOXM1 in all tumors puts a focusing lens on this gene as a candidate pan-cancer master regulator
PREDICTORES-DE-LA CONDUCTA EMPRESARIAL DE LAS MUJERES
No full textThe entrepreneurial capability is the acknowledgement of the opportunities to do something new from someone who, while
working in an organization, individuates and organizes the economic and human resources in order to reach the organization’s goals. The research intends to analyze the opinion that the basic population has regarding some constructs referred to the entrepreneurial capability, which are important entrepreneurial conduct prediction constructs (The internal control locus, the auto efficiency, the proactivity, the employability and the engagement). The investigation instrument is a questionnaire of self evaluation (COEM J. C. Sanchez, 2006). Which is composed by 14 sections that investigate on specific sectors, of business conduct.The basic population consists of 100 female workers on diverse feminine companies (Rome-Italy) between 29 and 62 years old. The last stage of the research has consisted in the construction of a basic control population. According with the results, there are no significant differences between both groups
Talent AndTalent Management In Organizations
No full textABSTRACT: The main aim of this paper is to develop a conceptual framework for literature on the
consequences of talented employees and talent management. Talent management is one of the most important
issues in all organizations. It is very important to identify the talented employees and use them in strategic jobs.
This article is to review near the past twenty years of the importance of using talents. At the result of this
research, provide the necessary information and knowledge in the field of discovering and employing valuecreation
and talent management process in the all organizations
Ekotemas, Revista Cubana de Ciencias economicas
No full textThe entrepreneurial capability is the acknowledgement of the opportunities to do something new from someone who, while working in an organization, individuates and organizes the economic and human resources in order to reach the organization’s goals. The research intends to analyze the opinion that the basic population has regarding some constructs referred to the entrepreneurial capability, which are important entrepreneurial conduct prediction constructs (The internal control locus, the auto efficiency, the proactivity, the employability and the engagement). The investigation instrument is a questionnaire of self-evaluation (COEM J. C. Sanchez, 2006). Which is composed by 14 sections that investigate on specific sectors, of business conduct.The basic population consists of 100 female workers on diverse feminine companies (Rome-Italy) between 29 and 62 years old.The last stage of the research has consisted in the construction of a basic control population. According with the results, there are no significant differences between both groups
Soft Skills in engeneers: a new field of research. Exploring and assessing skills in Italian Engeneers students
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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