186,339 research outputs found
Blennidus (Agraphoderus) bellesi Straneo 1993
No full text<i>Blennidus</i> (<i>Agraphoderus</i>) <i>bellesi</i> (Straneo, 1993) <p>(Figs. 16, 54, 92)</p> <p> <i>Ogmopleura bellesi</i> Straneo, 1993: 376 –377</p> <p> <i>Blennidus bellesi</i> (Straneo, 1993): Lorenz, 2005a: 262 <i>Blennidus bellesi</i> (Straneo, 1993): Lorenz, 2005b: 269 <i>Blennidus bellesi</i> (Straneo, 1993): Allegro & Giachino, 2011b: 173</p> <p> <b>Type locality.</b> Perulillos, entre Cajamarca y Celendin, Dpto. Cajamarca.</p> <p> <b>Examined material.</b> HT ♂ (CMa at MRSN); 3 PTT ♂ and 2 PTT ♀ (CMa, CSt); 11 ♂ and 4 ♀ (CAl, CGi, CMa).</p> <p> <b>Note.</b> The males of this species are distinguished by a subapical inner spiniform protuberance on mesotibia and by an obtuse one on metatibia. On account of the similar morphology of aedeagus, this species seems closely related to <i>B. negrei</i>, which is restricted to the same geographic area.</p> <p> <b>Distribution.</b> All the recorded specimens are from the Andes of northern Peru, Dept. of Cajamarca. In addition to the TS (legit Bellés 1977), many specimens have also been collected by M. Etonti.</p> <p> <b>Habitat.</b> The altitudinal data reported on the labels of the specimens collected by M. Etonti (4,000 m) suggest a preference of this species for the high altitude Andean grassland.</p>Published as part of <i>Allegro, Gianni & Giachino, Pier Mauro, 2015, Annotated checklist of the Blennidus subgenus Agraphoderus species from Peru with description of B. bombonensis n. sp. and synonymic notes (Coleoptera: Carabidae: Pterostichinae), pp. 1-48 in Zootaxa 4000 (1)</i> on page 6, DOI: 10.11646/zootaxa.4000.1.1, <a href="http://zenodo.org/record/289219">http://zenodo.org/record/289219</a>
Blennidus bellesi
No full text<i>Blennidus bellesi</i> group <i>sensu novo</i> <p> <b>Diagnosis.</b> Two species ranging in northern Peru (Dept. Cajamarca) distinguished by distinctive morphology of aedeagus and presence of a subapical inner spine in male mesotibiae:</p> <p> <i>B.</i> (<i>Agraphoderus</i>) <i>bellesi</i> (Straneo, 1993) <i>B.</i> (<i>Agraphoderus</i>) <i>negrei</i> (Straneo, 1993)</p>Published as part of <i>Allegro, Gianni & Giachino, Pier Mauro, 2015, Annotated checklist of the Blennidus subgenus Agraphoderus species from Peru with description of B. bombonensis n. sp. and synonymic notes (Coleoptera: Carabidae: Pterostichinae), pp. 1-48 in Zootaxa 4000 (1)</i> on page 19, DOI: 10.11646/zootaxa.4000.1.1, <a href="http://zenodo.org/record/289219">http://zenodo.org/record/289219</a>
Sleep and oligodendrocyte functions
No full textTranscriptomic studies have revealed that the brains of sleeping and awake animals differ significantly at the molecular level, with hundreds of brain transcripts changing their expression across behavioral states. However, it was unclear how sleep affects specific cells types, such as oligodendrocytes, which make myelin in the healthy brain and in response to injury. In this review, I summarize the recent findings showing that several genes expressed at higher levels during sleep are involved in the synthesis/maintenance of all membranes and of myelin in particular. In addition, I will discuss the effect of sleep and wake on oligodendrocyte precursor cells (OPCs), providing a working hypothesis on the function of REM sleep and acetylcholine in OPC proliferation.</p
Diagnostic difficulties with central nervous system actinomycosis
No full textWhen faced with expanding brain lesions of unknown origin showing a ring-shaped enhancement on post-contrast imaging, we use definite criteria to direct further investigation and distinguish among a number of possible diagnostic hypotheses. However, a correct diagnosis may be difficult in some cases, especially when dealing with less frequent conditions. This is the case of actinomycosis, a highly treatable but insidious infection for which nowadays there may be a low level of attention. Brain localization is associated with a significant morbidity and may represent a true diagnostic pitfall. Here we report the difficulties encountered with a case of central nervous system actinomycosis
Sleep quality relates to emotional reactivity via intracortical myelination
No full texta good quality and amount of sleep are fundamental to preserve cognition and affect. New evidence also indicates that poor sleep is detrimental to brain myelination. In this study, we test the hypothesis that sleep quality and/or quantity relate to variability in cognitive and emotional function via the mediating effect of interindividual differences in proxy neuroimaging measures of white matter integrity and intracortical myelination. by employing a demographically and neuropsychologically well-characterized sample of healthy people drawn from the human connectome project (n = 974), we found that quality and amount of sleep were only marginally linked to cognitive performance. In contrast, poor quality and short sleep increased negative affect (i.e. anger, fear, and perceived stress) and reduced life satisfaction and positive emotionality. at the brain level, poorer sleep quality and shorter sleep duration related to lower intracortical myelin in the mid-posterior cingulate cortex (p = 0.038), middle temporal cortex (p = 0.024), and anterior orbitofrontal cortex (OFC, p = 0.034) but did not significantly affect different measures of white matter integrity. finally, lower intracortical myelin in the OFC mediated the association between poor sleep quality and negative emotionality (p < 0.05). we conclude that intracortical myelination is an important mediator of the negative consequences of poor sleep on affective behavior
The Impact of Graft CD3 Cell/Regulatory T Cell Ratio on Acute Graft-versus-Host Disease and Post-Transplantation Outcome: A Prospective Multicenter Study of Patients with Acute Leukemia Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation
No full textAlthough it is well known that tumor site- or bone marrow-infiltrating regulatory T cells (Tregs) might be correlated with worse outcomes in solid tumors and acute leukemias by promoting immune surveillance escape, their contribution to the immediate post-allogeneic transplantation phase by peripheral blood (PB) allografts remains unclear. Moreover, the Treg content in stem cells harvested from PB has been suggested to be correlated with acute graft versus-host-disease (aGVHD) and immunologic recovery after allogeneic PB stem cell transplantation (allo-PBSCT). This study aimed to investigate the impact of the graft content of Tregs, as graft CD3+/Tregs ratio (gCD3/TregsR), on acute GVHD and post-allo-PBSCT outcomes. We prospectively enrolled 94 consecutive patients at 9 Italian centers of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) with acute myelogenous (n = 71; 75%) or lymphoblastic (n = 23; 25%) leukemia in complete remission who underwent matched related donor (n = 35; 37%) or unrelated donor (n = 59; 63%) allo-PBSCT. The median graft CD3+ cell, Treg, and gCD3/TregsR values were 196 × 106/kg body weight (range, 17 to 666 × 106/kg), 3 × 106/kg (range, 0.1 to 35 × 106/kg), and 71 (range, 1 to 1883), respectively. The discriminatory power of the gCD3/TregsR value to predict grade ≥II aGVHD was assessed by estimating the area under the receiver operating characteristic (ROC) curve (AUC). Any grade and grade ≥II aGVHD occurred in 24 (26%) and 17 (18%) allo-PBSCT recipients, respectively. By ROC analysis, AUC (0.74; 95% confidence interval [CI], 0.608 to 0.866; P =.002) identified 70 as the optimal gCD3/TregsR cutoff value predicting the appearance of grade ≥II aGVHD with 76% sensitivity and 71% specificity. Patients were subdivided into a high (ROC curve value ≥70) gCD3/TregsR group (HR; n = 48) and a low (ROC curve value <70) gCD3/TregsR group (LR; n = 46). The incidence of grade II-IV aGVHD was lower in the LR group compared with the HR group (9% [4 of 46] versus 27% [13 of 48]) in both univariate analysis (odds ratio [OR], 4.8; 95% CI, 1.44 to 16.17; P =.015) and multivariate analysis (OR, 5.0; 95% CI, 1.34 to 18.93; P =.017), whereas no differences were documented taking into account aGVHD of any grade. The overall survival, disease-free survival, nonrelapse mortality, and relapse rates at 2 and 3 years were 61% and 54%, 62% and 55%, 15% and 23%, and 27% and 30%, respectively. Of note, gCD3/TregsR did not significantly correlate with relapse (P =.135). Taken together, our data from this prospective multicenter study confirm the value of Tregs in preventing aGVHD while maintaining the graft-versus-leukemia effect. © 2021 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc
Sleep quality relates to emotional reactivity via intracortical myelination.
No full textA good quality and amount of sleep are fundamental to preserve cognition and affect. New evidence also indicates that poor sleep is detrimental to brain myelination. In this study, we test the hypothesis that sleep quality and/or quantity relate to variability in cognitive and emotional function via the mediating effect of interindividual differences in proxy neuroimaging measures of white matter integrity and intracortical myelination. By employing a demographically and neuropsychologically well-characterized sample of healthy people drawn from the Human Connectome Project (n = 974), we found that quality and amount of sleep were only marginally linked to cognitive performance. In contrast, poor quality and short sleep increased negative affect (i.e. anger, fear, and perceived stress) and reduced life satisfaction and positive emotionality. At the brain level, poorer sleep quality and shorter sleep duration related to lower intracortical myelin in the mid-posterior cingulate cortex (p = 0.038), middle temporal cortex (p = 0.024), and anterior orbitofrontal cortex (OFC, p = 0.034) but did not significantly affect different measures of white matter integrity. Finally, lower intracortical myelin in the OFC mediated the association between poor sleep quality and negative emotionality (p < 0.05). We conclude that intracortical myelination is an important mediator of the negative consequences of poor sleep on affective behavior
The apelinergic system immuno-detection in the abomasum and duodenum of sheep grazing on semi-natural pasture
No full textApelin (APLN) is an adipokine mainly produced by adipose tissue and related to an individual’s nutritional status as well as digestive apparatus functions. In this work, APLN and its receptor (APLNR) were investigated, by immunohistochemistry, in the abomasum and duodenum of 15 Comisana × Appenninica adult sheep reared in a semi-natural pasture. Organ samples were collected after maximum pasture flowering (M × F group) and after maximum pasture dryness (M × D group); the experimental group (E × p group) received a feed supplementation of 600 grams/day/head of barley and corn in addition to M × D group feeding. APLN and APLNR were identified in the lining epithelium and the fundic gland chief cells of the abomasum. APLNR was observed in the lining epithelium, in the crypts and the serotonin secreting cells of the duodenum. Similar reactivity was observed between the M × F and E × p groups, while the M × D group showed a lower intensity of immunostaining for both APLN and APLNR in all positive structures but the duodenal serotonin neuroendocrine cells. Hence, our findings show that the E × p group presents a picture quite overlapped with M × F and suggest that food supplementation has a maintaining effect on the apelinergic system expression in the investigated digestive tracts of the sheep
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