699 research outputs found
About Nikolay Kolyada
No full textThe article presents a transcript of a talk with N. L. Leiderman about N. Kolyada, recorded in February 2010. The author speaks in detail about his meetings with the dramatist, about the history of writing his monograph «Dramatic Works of Nikolay Kolyada» and provides an analysis of the dramatist‘s creative legacy. N. L. Leiderman also dwells on the reasons of popularity of N. Kolyada both in Russia and in the West. The author touches upon the modern state of the Kolyada Theatre and the role of the dramatist in the creation of the Urals dramatic school
Yakut author Nikolay Luginov and his stories
No full text1970 sonrasında yazmaya başladığı ilk hikayeleri ile edebiyat dünyasına adım atan Nikolay Luginov, Saha (Yakut) edebiyatının önde gelen temsilcilerinden birisidir.
Nikolay Luginov'un hikayeleri üzerinde ayrıntılı bir çalışma yapmak ve yazarın modern Yakut edebiyatındaki yerini ortaya koymak amacıyla yapılan bu tezde hikayeler üzerinde metin merkezli bir inceleme yapılmıştır.
Tezimizin "Giriş" bölümünde, tezin amacı, araştırma yöntemleri ile Saha (Yakut) Türkleri ve Saha (Yakut) edebiyatının gelişim süreçleri hakkında genel bir bilgi verilmiştir.
Birinci bölümde, Nikolay Luginov'un hayatı, edebi kişiliği ve eserleri ele alınmıştır. Bu bölümde Nikolay Luginov'un, hikayeden roman türüne geçiş sürecine ve yazarın son çalışmalarına değinilmiştir.
Çalışmamızın ikinci bölümünde, Nikolay Luginov'un üç hikayesi tahlil edilmiş, hikaye tahlillerinde önce olay örgüsü, ardından özet, şahıs kadrosu, zaman ve mekan incelemesi yapılmıştır. Ayrıca hikayelerde yer alan mitolojik ve geleneksel unsurlar ele alınmıştır.
“Sonuç” bölümünde ise Nikolay Luginov’un edebi kişiliği ve eserleri üzerinde yapılan incelemenin sonuçları, yazarın dünya görüşü çercevesinde değerlendirilmiştir.One of the leading representatives of Saha (Yakut) literatureNikolay Luginov involved into the literary word with his first storieswhich he started to write after 1970.
In order to present a detailed study on the stories of Nikolay Luginov and to reveal the place of the author in Saha (Yakut) literatur, the stories of Luginov was examined with a text-cnetered approach.
General information about Yakut Turks and development processes of Yakut literature and aim of the thesis, research methods are given in the “Introduction” section of the thesis.
In the first chapter, Nikolay Luginov’s life, literary identity and his Works were discussed. In the section,Nikolay Luginov’s literary transition process from story to lovel and the aothor’s recent works were eveluated.
Three storiew of Nikolay Luginov were analyzed in the second part of the study. First the plot then the summary, charecters, time and space were examined in the story analysis. Moreover, the mythological and traditional elements in the stories were discussed.
The results of the study into the literary identiy and Works of Nikolay Luginov were presented within the framework of the auuthor’s word view in the conclusion section
Upregulation of YKL-40 Promotes Metastatic Phenotype and Correlates with Poor Prognosis and Therapy Response in Patients with Colorectal Cancer
Full text linkYKL-40 is a heparin- and chitin-binding glycoprotein that belongs to the family of glycosyl hydrolases but lacks enzymatic properties. It affects different (patho)physiological processes, including cancer. In different tumors, YKL-40 gene overexpression has been linked to higher cell proliferation, angiogenesis, and vasculogenic mimicry, migration, and invasion. Because, in colorectal cancer (CRC), the serological YKL-40 level may serve as a risk predictor and prognostic biomarker, we investigated the underlying mechanisms by which it may contribute to tumor progression and the clinical significance of its tissue expression in metastatic CRC. We demonstrated that high-YKL-40-expressing HCT116 and Caco2 cells showed increased motility, invasion, and proliferation. YKL-40 upregulation was associated with EMT signaling activation. In the AOM/DSS mouse model, as well as in tumors and sera from CRC patients, elevated YKL-40 levels correlated with high-grade tumors. In retrospective analyses of six independent cohorts of CRC patients, elevated YKL-40 expression correlated with shorter survival in patients with advanced CRC. Strikingly, high YKL-40 tissue levels showed a predictive value for a better response to cetuximab, even in patients with stage IV CRC and mutant KRAS, and worse sensitivity to oxaliplatin. Taken together, our findings establish that tissue YKL-40 overexpression enhances CRC metastatic potential, highlighting this gene as a novel prognostic candidate, a predictive biomarker for therapy response, and an attractive target for future therapy in CRC
Transformations of respiratory epitelium in fibrous stage of acute respiratory distress-syndrome = Трансформация респираторного эпителия в фазу фиброза острого респираторного дистресс-синдрома
Full text linkNovikov Nikolay, Tumansky Valery, Fedotov Vasiliy. transformations of respiratory epitelium in fibrous stage of acute respiratory distress-syndrome = Трансформация респираторного эпителия в фазу фиброза острого респираторного дистресс-синдрома. Journal of Health Sciences. 2014;4(14):117-120. ISSN 1429-9623 / 2300-665X.
http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2814%29%3A117-120
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A117-120
https://pbn.nauka.gov.pl/works/512256
DOI: 10.5281/zenodo.13322
http://dx.doi.org/10.5281/zenodo.13322
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).
© The Author (s) 2014;
This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
Conflict of interest: None declared. Received: 15.11.2014. Revised 05.12.2014. Accepted: 10.12.2014.
transformations of respirAtory epitelium in fibrous stage of acute respiraTory distress-syndrome
Трансформация респираторного эпителия в фазу фиброза острого респираторного дистресс-синдрома
Nikolay Yu Novikov
Crimean State Medical University, Simferopol, Russian Federation
Valery Alexeevich Tumansky
Zaporozhye State Medical University, Ukraine
Vasiliy Vladimirovich Fedotov
Crimean State Medical University, Simferopol, Russian Federation
Corr. Author
Новиков Николай Юльевич
докт. мед. наук, доцент ГУ «КГМУ имени С.И.Георгиевского», РФ, г. Симферополь
Е-mail: [email protected]
Трансформация респираторного эпителия в фазу фиброза острого респираторного дистресс-синдрома
АННОТАЦИЯ
Цель. Определение признаков эпителиально-мезенхимальной трансформации (ЭМТ) для установления ее роли в развитии фиброза легких у пациентов с острым респираторным дистресс-синдромом. Метод. Иммуногистохимическое окрашивание гистологических срезов. Результат. В большинстве альвеолоцитов обнаруживается экспрессия маркеров эпителиального иммунофенотипа. Признаки мезенхимальной дифференцировки определяются в единичных альвеолоцитах. Вывод. ЭМТ не играет существенной роли в формировании фиброза респираторного отдела при ОРДС.
Ключевые слова: респираторный эпителий; легкие; дистресс-синдром.
transformations of respirAtory epitelium in fibrous stage of acute respiraTory distress-syndrome
ABSTRACT
The epithelial-mesenchimal transition of respiratory epithelium in Acute Respiratory Distress Syndrome (ARDS) was goal of investigation. Postmortem immunohistochemical stain of respiratory part histological sections was methods. Result: epithelial immunofenotype of epithelial cells was determinate in more cases. Conclusion. The epitelial-mesenchimal transition does not play main role to lungs fibrosis in ARDS.
Keywords: respiratory epitelium; lungs; distress-syndrome.Novikov Nikolay, Tumansky Valery, Fedotov Vasiliy. Transformations of respiratory epitelium in fibrous stage of acute respiratory distress-syndrome = Трансформация респираторного эпителия в фазу фиброза острого респираторного дистресс-синдрома. Journal of Health Sciences. 2014;4(14):117-120. ISSN 1429-9623 / 2300-665X.
http://ojs.ukw.edu.pl/index.php/johs/article/view/2014%3B4%2814%29%3A117-120
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A117-120
https://pbn.nauka.gov.pl/works/512256
DOI: 10.5281/zenodo.13322
http://dx.doi.org/10.5281/zenodo.1332
On the anniversary of Academician Nikolay Kazimirovich Yankovsky
Full text linkJune 21, 2023, marks the 75th anniversary of RAS Academician Nikolay Kazimirovich Yankovsky, an eminent specialist in the field of general and molecular genetics and biotechnology. Nikolay Kazimirovich has published more than 170 scientific papers, has nine patents, trained six Doctors and 19 Candidates of Science. He is a laureate of the USSR Council of Ministers Prize and several other awards. Nikolay Kazimirovich carries out extensive editorial work, being the Editor-in-Chief of the Journal “Genetics” and a member of editorial boards of a few other specialized periodicals. N.K. Yankovsky is also known as a major organizer in science; in 2006-2016 he held the position of Director of the Institute of General Genetics of the Russian Academy of Sciences, and currently he is the Scientific Director of this Institute. Nikolay Kazimirovich carries out extensive educational work, being the author of dozens of popular scientific publications and presentations in the mass media. It is impossible to overestimate the contribution of N.K. Yankovsky into the work of the Russian genetic community in the rank of the first Vice-President of the Vavilov Society of Geneticists and Breeders, in which position he has always been and still is a generator of new ideas and an active fighter for the ideals of genetic science. Friends and associates – Russian geneticists and breeders, congratulate Nikolay Kazimirovich on his anniversary and wish him achieving new creative successes, grateful apprentices, enthusiasm and inexhaustible energy in solving large-scale challenges of genetics on a national and global scales
The Epoch and Personality of Peter the Great in Nikolay Charykov’s Research
No full textThe article reviews the academic contribution of Russian historian and diplomat Nikolay Charykov (1855-1930) to our understanding of the reforms by Peter the Great. In his research, Nikolay Charykov argues that the reforms did not result in a radical break with previous Russia's historical path. He stresses that the cultivation of scientific knowledge and labor skills necessary for modernization started in Russia long before Peter the Great because Russia was part of a European system even before Peter the Great. For example, the author points to Ivan III's marriage to Zoe Palaiologina (Sophia Palaiologina); the employment of captive Livonians by Ivan IV; sending Russian youth to study at Western European universities; Boris Godunov's plans to form a European league of Christian sovereigns. Nikolay Charykov focuses in his studies on the reign of Tsar Alexei Mikhailovich, pointing to his plans to increase the involvement of Westerners in various spheres of life in Russia. Moreover, Nikolay Charykov shows that the personality of the future Emperor was formed under the influence of Russia's increasing interaction with European countries. He concludes that the development of Russia before Peter led to Peter's reforms. He saw the struggle between Sophia and Peter as an interpersonal struggle for power, which in no way violated the primary trend of Russia's development. Peter's reforms became a logical and natural consequence of the previous processes. The merit of Peter was that he successfully continued the previously started transformations by adding to them his character and thinking, which led to the birth of the Russian Empire
Nikolay Kirsanov in the System of Characters in the Novel “Fathers and Sons” by Ivan Turgenev
No full textThe aim of the article is to study the character of Nikolay Kirsanov and its role in the novel “Fathers and Sons” since, until recently, this character has been rather neglected, and both national and foreign critics have focused on a standard, and often schematic, enumeration of some positive qualities of the character’s personality. In order to achieve the aim and to probably reconsider the ideas and thematic plot of the novel by I. Turgenev in general, the hermeneutic, biographical and cultural-historical methods are used in the article in the context of receptive aesthetics. The suggested approach has enabled the author to argue that the personality traits of Nikolay Petrovich are determined by his relationship with Fenechka because in this case they find themselves under pressure of social inequality, significant age difference, and their mutual illegitimate son. Such an unusual behavior of a basically positive character is motivated by his belonging to the infernal sphere, which is interpreted by means of the image of “le Diable Boiteux”, i.e. “a lame devil”, with all customs and traditions of the landowners and nobility represented in it. Moreover, the character of Nikolay Petrovich Kirsanov embodied Turgenev’s personal traumatic experience concerning the writer’s illegitimate daughter. All this has allowed the author to make a conclusion that it is possible to partially reconsider most of the novel characters due to their involvement into the ambiguous situation which formed because of one of the Kirsanov brothers. The role of the character of Nikolay Petrovich and its place in the system of characters in the novel “Fathers and Sons” consists in the fact that thanks to this contradictory character, the book obtains additional pier- cing human impulse, which ensures immortality of the genius Russian writer’s literary work
Nikolay Leskov (1831-1895) ve Rusya'da Edebiyat ve İdeoloji
No full textIt is includes the society, culture, ideology and political movements of the period through the works and thoughts of the writer Nikolai Leskov who lived in the 19th century. In this study, the views of Nikolai Leskov about the tsars on the throne, political thoughts, philosophies and movements are examined and his position against the ideas of Westernizers and Slavophiles and nihilism movement that appearing in 19th century Russia are discussed.
Leskov, who entered literature with his journalism career, depicts the society of the period in his works. With these characters reflected in his works, we can learn about Russian human typology of the 19th century. In the first part, the era of the author, in the second part, the life of the author and in the last part, his two classical works are examined. With the work of Lady Macbeth from Mtsensk District, Leskov describes the women issue that emerged in the 19th century, and with the work The Sealed Angel, the author describes the Old Believers community living in miniature states. Both works are important in terms of allowing us to understand the period.19. yüzyılda yaşamış yazar Nikolay Leskov’un eserleri ve düşünceleri üzerinden dönemin toplumunu, kültürünü, ideolojisini ve politik cerayanlarını içermektedir. Bu çalışmada Nikolay Leskov’un, yaşadığı dönemde tahtta bulunan çarlar, siyasi düşünceler, felsefeler ve akımlarla ilgili görüşleri incelenmekte ve 19. yüzyıl Rusya’sında ortaya çıkan nihilizm akımı ve Batıcılık ve Slavcılık düşünceleri karşısındaki konumu tartışılmaktadır. Gazetecilik kariyeriyle birlikte edebiyata giren Leskov eserlerinde dönemin toplumunu resmetmektedir. Eserlerine yansıyan bu karakterler ile 19. yüzyılın Rus insan tipolojisi hakkında bilgi edinebilmekteyiz. İlk bölümde yazarın yaşamış olduğu çağı, ikinci bölümde yazarın hayatını ve son bölümde ise iki klasik eseri incelenmektedir. Mtsenskli Lady Macbeth eseriyle Leskov 19. yüzyılda gündeme gelen kadın sorununu, Mühürlü Melek eseriyle ise minyatür devletler halinde yaşayan Kadim Müminler topluluğunu anlatmaktadır. Her iki eserde, dönemi idrak edebilmemize olanak sağlaması açısından mühimdir
ON THE INTERPRETATION OF V. BRUSOV’S CORRESPONDENCE. INTRODUCTORY REMARKS. COMMENTS AND NOTES BY NIKOLAY BOGOMOLOV
No full textThe paper’s author publishes V. Brusov’s letters to Shesterkina, which were already published by M. Gasparov. The author adjusts some of conclusions drawn by M. Gasparov, on the basis of the same letters
Mechanisms of Understanding: Nikolay A. Rubakin’s Mnema Theory
Full text linkThe study provides a brief overview of the Mnema Theory, a bibliopsychological theory based on the achievements in physiology and evolutionary biology formulated by Russian bibliographer, book critic, popularizer of science and writer Nikolai Alexandrovich Rubakin (Nicholas Rubakin), and the one which allows consistently and vividly reveal the structure of the human psyche, and show the mechanisms associated with understanding in general and understanding words and text, in particular. The Theory of Mnema, although presented to the scientific community at the beginning of the 20th century, is nevertheless highly relevant after a hundred years, and there continues to be more and more evidence pointing to the veracity and credibility of its provisions from modern humanitarian and natural sciences. Nikolay A. Rubakin’s Theory of Mnema is formulated on the basis of three laws of bibliopsychology: Zemon’s Law, Humboldt-Potebnya’s Law and Teng’s Law, and shows the structure of the human psyche in the form of mnema, which is a system of records received from external stimuli. According to Nikolay A. Rubakin’s theory, the mnema are a complex open system that is in a state of permanent development, and is always being added to and is continually changing. The complex composition of the reader’s mnema determines the perception and interpretation of a text, which is also understood as the external stimulus that generates a set of engrams and their activation leading to their subsequent ecphorias, as well as the projections that a reader receives when understanding texts. The validity of Nikolay A. Rubakin’s Theory of Mnema is confirmed by psychophysiological experiments aimed at measuring the semantic proximity of words (experiments of A.R. Luria and O.S. Vinogradova), psychological and psycholinguistic experiments (for example, Rorschach tests and various kinds of associative experiments), as well as the achievements of the philological science itself with regard to the study of the space of artistic and non-artistic text, the actual images of the author and the characteristics of the interpretations of the text by readers and researchers
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