1,720,958 research outputs found
Levosulpiride vs. pimozide in negative symptoms of schizophrenia
No full textThe primary objective of this study was to compare the therapeutic effect of low-dose levosulpiride with pimozide in a representative sample of patients with negative symptoms of schizophrenia. As a secondary objective, possible synergism between haloperidol and levosulpiride was evaluated. The safety of the two drugs in association with haloperidol was also compared. This was a single-masked (the patient), randomized, controlled, clinical study performed on 20 hospitalized patients randomly assigned to one of two groups. The drugs under study were administered orally, during a 60-day period, at the following doses: levosulpiride 200 mg/d or pimozide 4 mg/d. All patients had chronic schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition, Revised, with predominant negative symptoms, following Andreasen's diagnostic criteria, based on rating scales for negative and positive symptoms of schizophrenia. Low-dose levosulpiride showed a definite therapeutic effect on negative symptoms of schizophrenia. The therapeutic activity of levosulpiride was higher than that of pimozide. A particular type of synergism between levosulpiride and haloperidol was also suggested, as negative symptoms of schizophrenia, which are not relieved by haloperidol alone, were significantly ameliorated by adding levosulpiride to the therapeutic schedule. The combination of levosulpiride plus haloperidol did not increase the incidence of side effects; in fact, the incidence of side effects with combination therapy was decreased in comparison with that of haloperidol monotherapy. The total number of side effects was similar during combination therapy with pimozide plus haloperidol and during haloperidol monotherapy
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Levosulpiride vs. pimozide in pazienti schizofrenici: efficacia ed eventi avversi
No full textThe present study aims to compare the therapeutic effect of low-dose levosulpiride with pimozide, in a representative sample of patients with negative symptoms of schizophrenia and in particular it analyses side effects. The second aim of this study is the evaluation of the possible synergism between haloperidol and levosulpiride. The safety of the two drugs administered in association with haloperidol can therefore be compared. This study shows that levosulpiride is more effective in schizophrenic patients. The onset of levosulpiride activity is rapid, significant after 30 days of treatment, and it has effect on all clusters of SANS symptoms; the significant amelioration continues during the next 30 days of treatment. The present study is a preliminary report on the possible synergistic and complementary activity of levosulpiride and haloperidol in the treatment of schizophrenia with negative symptoms. Our findings, in agreement with other data, support the hypothesis that the therapeutic combination of haloperidol and levosulpiride is associated with a decreased incidence of side effects in comparison with haloperidol monotherapy. These preliminary results must be duplicated in a larger number of schizophrenic patients, both in association with haloperidol and in monotherapy, to confirm the positive synergistic activity of low-dose levosulpiride and haloperidol on negative symptoms of schizophrenia and to compare the therapeutic activity of monotherapy of levosulpiride with other antipsychotic drugs
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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