1,686,246 research outputs found
TAA polyepitope DNA-based vaccines: a potential tool for cancer therapy
No full textDNA-based cancer vaccines represent an attractive strategy for inducing immunity to tumor associated antigens (TAAs) in cancer patients. The demonstration that the delivery of a recombinant plasmid encoding epitopes can lead to epitope production, processing, and presentation to CD8+ T-lymphocytes, and the advantage of using a single DNA construct encoding multiple epitopes of one or more TAAs to elicit a broad spectrum of cytotoxic T-lymphocytes has encouraged the development of a variety of strategies aimed at increasing immunogenicity of TAA polyepitope DNA-based vaccines. The polyepitope DNA-based cancer vaccine approach can (a) circumvent the variability of peptide presentation by tumor cells, (b) allow the introduction in the plasmid construct of multiple immunogenic epitopes including heteroclitic epitope versions, and (c) permit to enroll patients with different major histocompatibility complex (MHC) haplotypes. This review will discuss the rationale for using the TAA polyepitope DNA-based vaccination strategy and recent results corroborating the usefulness of DNA encoding polyepitope vaccines as a potential tool for cancer therapy
SRNICEK NICK,PLATFORM CAPITALISM, POLITYPRESS, 2017, PP.171
No full textThe text includes a review of Nick Srnicek's book on Platform Capitalism (2017). The book explores the mechanisms that enable the process of economic accumulation of digital platforms. As such, the author explores some of the key elements that characterize the platform economy: the collection of consumer/user data, the network effect, and its politics. The author of the book review summarizes the main themes of the book and critically examines its merits and aspects that have not yet been explored by the text
Vacuum dependent bell local hidden variable models and generalized C.H.S.H. inequalities
No full textWe extend a previous model of the author which generalizes Bell local hidden variable models to the case of entangled photon pairs assuming that the standard Bell correlation functions depend on a hidden vacuum index. We deduce a generalization of Bell theorem assuming that classical observables are not dichotomic and that photon pair emission and detection is not a stationary stochastic process. We derive a photon imperfect polarization correlation functions due to rotational invariance breaking induced by hidden vacuum spin currents. We implement formally this approach deducing a generalization of C.H.S.H. inequalities which asymptotically converges to the standard one and which might be competitive with standard quantum mechanics predictions. We suggest to test this inequalities conceiving new E.P.R.-Bell like tests with time dependent detector efficiency and photon flux. Finally, we suggest to apply these generalized inequalities to the correlation functions of entangled classical spinning waves realized recently with metamaterials
Gene und Klone Moeglichkeiten sowie ethische Grenzen der Bio- und Gentechnologie bei Tieren
No full textInhaltsverzeichnis: Helmut Geiger: Begruessung und Einfuehrung in die Tagung (1-5); Heiner Niemann: Bio- und Gentechnologie bei Tieren: Herausforderungen fuer Wissenschaft und Praxis (6-12); Guenter Altner: Ethische Aspekte von Klonierung und Gentechnologie bei Tieren (14-27); Burkhard Meinecke: Reproduktionsbiotechnik als Voraussetzung fuer gentechnische Verfahren (30-33); Alexander Herzog: Genomanalytik fuer Tierzucht, Tiergesundheit und Produktqualitaet (38-44); Katja Prelle: Transgene Tiere in Tierzucht und Veterinaermedizin (47-53); Detlev Ganten: Transgene Tiere - ihre Nutzung in der Humanmedizin (58-64); Horst Moosmann: Tierschutzaspekte bei transgenen Tieren (67-73); Wolfgang Baumgaertner: Verfahren auf molekularbiologischer Basis in der veterinaermedizinischen Diagnostik (78-84); Tobias Schlapp: Molekularbiologische Grundlagen in der Impfstoff- und Arzneimittelherstellung (85-93); Anita Idel: Risikowahrnehmung und Riskobewertung (96-102); Albrecht Mueller: Bewertung der Bio- und Gentechnologie bei Tieren aus der Sicht der philosophischen Ethik (103-109); Michael Schlitt: Bewertung der Bio- und Gentechnologie bei Tieren aus christlicher Verantwortung (110-121); Christoph A. Reinhardt: Bewertung der Bio- und Gentechnologie bei Tieren aus wissenschaftspolitischer Sicht (127-136); Uwe Nickel: Bewertung der Bio- und Gentechnologie bei Tieren aus tierschuetzerischer Sicht (141-145); Daniel Ammann: Gentechnik und Patentierung von Tieren. Bewertung aus kultureller Sicht (151-157); Barbara Harlizius: Auswirkungen der Bio- und Gentechnologie auf die Tierzucht (160-161); Antoine F. Goetschel: Derzeitige Rechtslage und Handlungsbedarf (164-176); Nikolaus Voetz: Moeglichkeiten sowie ethische Grenzen der Bio- und Gentechnologie bei Tieren - europaeische Aspekte (181-189); Reinhard Kroker: Die Zulassung von gentechnisch hergestellten Tierarzneimitteln: Aspekte zur Tiergesundheit und zum Verbraucherschutz (191-198); Marion Selig: Ergebnisse der Tagung aus der Sicht des Tierschutzes (201-203); Diedrich Smidt: Ergebnisse der Tagung aus tieraerztlicher Sicht (204-206); Bernd Hoffmann: Ergebnisse der Tagung aus Sicht tiermedizinischer Forschung und Wissenschaft (207-209); Elmar Doppelfeld: Ergebnisse der Tagung aus humanmedizinischer Sicht (210-212); Plenumsdiskussion (213-224); Helmut Geiger: Schlusswort (225-227); Helmut Geiger: Bedroht Klonen die Individualitaet von Lebewesen? (228-232); Helmut Geiger: Allmachtsphantasien in der Biotechnologie? (233-238)Available from UuStB Koeln(38)-980106461 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
狮子林园
No full textHall of Faint Fragrance and Thin Shadows, upper balcony walkway; The Lion Grove Garden is famous for the large and labyrinthine grotto of taihu rock (from Lake Tai) at the garden's center. The name of the garden derives from the shape of these rocks which are said to resemble lions. These served as frequent subjects for artists such as Shen Zhou and Ni Zan. The Lion Grove Garden was first built in 1342 CE during the Yuan Dynasty by a Zen Buddhist monk, Wen Tianru in memory of his teacher Abbot Zhongfeng. At that time the garden was part of Bodi Orthodox Monastery (Pinyn: Puti Zhengzong). There were building phases in the 18th and 19th centuries. In 1917 Bei Runsheng, wealthy owner of a paint business, purchased the garden and finished the restoration in 1926. Many buildings and rocks date from this restoration. Bei Runsheng was the great-uncle of the architect I. M. Pei (Bei Yuming). It is recognized with other classical Suzhou gardens as a UNESCO World Heritage Site. Source: Wikipedia; http://en.wikipedia.org/wiki/Main_Page (accessed 8/5/2012
狮子林园
No full textInterior, Hall of Flower Baskets, detail, roof structure; The Lion Grove Garden is famous for the large and labyrinthine grotto of taihu rock (from Lake Tai) at the garden's center. The name of the garden derives from the shape of these rocks which are said to resemble lions. These served as frequent subjects for artists such as Shen Zhou and Ni Zan. The Lion Grove Garden was first built in 1342 CE during the Yuan Dynasty by a Zen Buddhist monk, Wen Tianru in memory of his teacher Abbot Zhongfeng. At that time the garden was part of Bodi Orthodox Monastery (Pinyn: Puti Zhengzong). There were building phases in the 18th and 19th centuries. In 1917 Bei Runsheng, wealthy owner of a paint business, purchased the garden and finished the restoration in 1926. Many buildings and rocks date from this restoration. Bei Runsheng was the great-uncle of the architect I. M. Pei (Bei Yuming). It is recognized with other classical Suzhou gardens as a UNESCO World Heritage Site. Source: Wikipedia; http://en.wikipedia.org/wiki/Main_Page (accessed 8/5/2012
Inhibition of Mek 1/2 kinase activity and stimulation of melanogenesis by 5,7-dimethoxycoumarin treatment of melanoma cells
No full textIn this study, the processes of differentiation and melanogenesis induced by 5.7-dimethoxycoumarin in murine (B16) and human (A375) melanoma cells were investigated. Taking into account the previously demonstrated anti-proliferative and differentiation activities of this compound, we examined Ras/Raf/Mek/Erk mitogen-activated protein kinase activity following treatment; inhibition of Mek 1/2 kinase activity and Subsequent reduction in Erk 1/2 activation were detected in both cell types. We observed melanogenesis induction associated to an increase in cAMP-response element-binding protein (CREB) and microphthalmia-associated transcription factor (Mitf) expression, both involved in its regulation. Mitf is fundamental for development, survival and differentiation of melanocyte and melanoma, since it regulates transcription of genes encoding for proteins involved in cell cycle progression or in melanogenesis, such as the enzyme tyrosinase. A significant increase of tyrosinase activity was revealed following treatment in B16 but not in A375 cells. although a strong synthesis of melanin was induced by 5,7-dimethoxycoumarin in both cell lines. The treatment induced protoporphyrine IX accumulation involved in melanogenesis since it promotes stability of cAMP. Finally, the Mek 1/2 inhibitor U0126 significantly potentiated growth inhibition of B16 cells triggered by 5,7-dimethoxycoumarin, suggesting that down-regulation of Raf/Mek/Erk pathway sensitizes melanoma cells to 5,7-dimethoxycoumarin treatment
The regulation of platform-mediated touristification: a comparison of European cities
No full textThe development of online digital platforms represented an influence urban phenomenon impacting on traditional hotel industry and on housing exacerbating the overtourism that characterizes the contemporary environments on cities. This sector produced several negative and positive externalities. however, that issue acquired a notable influence in the public and political arena. The new modalities of economical intermediation promoted by digital platforms, among the most relevant is Airbnb, bypassed the norms that regulate the tourism accommodations. Furthermore, in the last few years, the major tourists’ European cities implemented regulations in order to mitigate the negative effects produced by the platform-mediated touristification. The regulatory approaches developed by several cities are different for the aims that they want to achieve and for the stringency that they put in place. Consequently, the paper wants to clarify the normative patters that characterize some among the major European tourist cities, classifying the approaches from the most lenient to the strongest. The methods used to analyse that phase of research are the study of policy documents produced by local authorities. The further aim proposed by that paper is the assessment of the impact produced by different approaches. The method used to achieve that result is a counterfactual analysis that compare the cities that were subject to the regulations and the cities that didn’t were subject to the regulations. A general aim will be outlining the political responses of European urban administrations and offer some suggestions in order to better regulate this issue
Modeling and Analysis of Multilayer Complex Distribution System: A Multi-Agent Simulation for Decision Making
No full textIn the context of emerging distribution system with large penetration of distributed generation and storage from prosumers, we consider the distribution system as a multi-layers interacting complex system. The complexity of the system, characterized by several interacting layers fit in the context of physical (network), cyber, social and natural environment, cannot be captured by closed form mathematical models and new approaches derived from complex sciences, as Multi Agent Simulation (MAS), will be employed for developing proper tools. Based on MAS, where individual arbitrariness and realities can be represented almost as in detail as designers want, complex decision making problems encountered in the emerging distribution system can be implemented, learned, and evaluated through predesigned MAS models; evolutions of complex multilayer system and interactions inside can be captured with utmost concretes. Future projections such as emerging distribution system can be simulated ex-ante; perplexities that may arouse can be diagnosed and even resolved in advanc
L’Università dei Falegnami e l’Arciconfraternita di San Giuseppe nella chiesa al Foro Romano
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