1,721,031 research outputs found

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    The role of gammadelta T cells in the immunity against Epstein-Barr virus

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    1-10 % der humanen peripheren Lymphozyten sind gammadelta(gd)-T-Zellen. Sie sind an der Abwehr von Infektionen beteiligt. In dieser Arbeit wurden mehrere hundert gd-T-Zell-Klone phänotypisch beschrieben und deren Zytotoxizität gegenüber EBV-infizierten B-Zellen untersucht, um eine mögliche Rolle bei der Bekämpfung von Epstein-Barr-Virus(EBV)-Infektionen zu erforschen. Es konnte gezeigt werden, dass zwischen gd-T-Zell-Klonen und B-Zellen zielgerichtete zytotoxische Interaktionen stattfanden, die meist vom EBV-Status der B-Zellen abhingen. Dies untermauert die Hypothese einer Rolle der gd-T-Zellen in der Immunität gegen EBV.Gammadelta(gd) T cells account for 1-10% of the human peripheral lymphocytes. They are involved in the defense of infections. In this study, we analyzed the phenotype and cytotoxic functions of several hundred gd T cell clones in order to determine a possible role in the protection against Epstein-Barr virus (EBV) infections. It could be demonstrated that cytotoxic interactions occur between gd T cell clones and B cells. These interactions were predominantly found to be dependent on the EBV status of the target cells. This strongly supports the hypothesis of a role of gd T cells in the immunity against EBV

    CD4(+)-T-Zellantwort auf EBV-Strukturantigene: die Rolle der lytischen Antigene BNRF1 und gp350

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    The topic of this work is the MHC class II-restricted immune answer to the infection with Epstein-Barr virus (EBV), a ubiquitous human pathogenic virus. In a first step, the frequency of EBV-specific CD4+ T cells in the blood of healthy EBV-positive donors was detected and subsequently compared to the one of patients with infectious mononucleosis. In a second step, two structural antigens of EBV, gp350 and BNRF1, were used to generate specific CD4+ T cell lines. Their reactivity and specificity were analyzed and the HLA molecules relevant for antigen presentation were determined.Diese Arbeit beschäftigt sich mit der MHC Klasse II-restringierten Immunantwort auf die Infektion mit dem humanpathogenen Epstein-Barr-Virus (EBV). Zum einen wurde die Frequenz von EBV-spezifischen CD4(+)-T-Zellen im Blut gesunder EBV-positiver Spender untersucht und mit der von Patienten mit infektiöser Mononukleose verglichen. Zum anderen wurden für die Virusstrukturantigene gp350 und BNRF1 spezifische CD4(+)-T-Zelllinien hergestellt, deren Reaktivität und Spezifität, sowie die für die Antigenpräsentation relevanten HLA-Moleküle ermittelt

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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