49 research outputs found
Evaluación del conocimiento sobre terapias de última generación en la ciudadanía de habla española
No full textIntroducción: Actualmente existe un gran desconocimiento sobre las terapias innovadoras, lo cual genera desconfianza y puede limitar la participación de los pacientes en investigación. Objetivos: Analizar el nivel de conocimiento de la ciudadanía en materia de terapias innovadoras. Metodología: El análisis se realizó a través de una encuesta en línea de 30 preguntas. Resultados: La encuesta fue completada por 518 personas y se detectaron varios temas a reforzar, entre los que destacaron: enfermedades a las que se dirigen estas terapias, efectos secundarios o conceptos como “vector” o “mutación”. Los encuestados señalaron como formatos preferidos conferencias impartidas por profesionales, vídeos e infografías. Internet fue la fuente de información preferente, concretamente los medios científicos especializados y las páginas web de instituciones oficiales. Conclusión: Se propone una campaña educativa compuesta por una serie de charlas en formato semipresencial impartidas por expertos con formación en comunicación. También se recomienda el co-diseño de una colección de materiales y su difusión a través de páginas web, redes sociales o medios especializados.</jats:p
Internet of things in business & management: Current trends, opportunities and future scope
No full textThe study explores the theme of Internet of Things in business and management by conducting bibliometric analysis of extant literature on the topic. SPAR-4-SLR protocol methodology of systematic literature review is employed for bibliometric analysis. Year-wise, Author-wise, Citation-wise, Country-wise, Source-wise, Affiliation-wise, Sponsoring institutions-wise and keywords-wise listing are the parameters to identify the trend, opportunities, and future scope of this theme. We use Scopus database to list the extant literature. The study suggests that IoT in business and management is going to be explored in relation to digital transformation, fog computing, soft computing, embedded system, industry 4.0, circular economy, sustainable development, and smart cities and subsequently this wide-spread application of IoT in Business & Management also brings certain challenges like cyber-security, reliability, privacy, and complexity in working. This study provides insights on current trends and the future scope of IoT in business and management which is equally useful for researchers and policy maker
Young patients’ involvement in a composite endpoint method development on acceptability for paediatric oral dosage forms
No full textAbstract Background In line with the European Paediatric Regulation, the European Medicines Agency (EMA) asks for investigation of a medicine’s acceptability in paediatric medicines development. A standardised acceptability testing method combining the outcome of “swallowability” and “palatability” assessments to a “composite endpoint on acceptability” was recently developed. Before this method’s suitability for selection of the most acceptable drug formulation of a new medicine for children can be broadly recommended, the acceptance and relevance of such established acceptability needs the critical review and input from young patients with understanding of the medicines development methodology. The benefit of involving patients in drug product development, clinical research and innovation is well established. Methods During a focus group meeting with the KIDS Barcelona (young people advisory group, age 16–23 years) the suitability of the “composite endpoint on acceptability” methodology was assessed. Via electronic questionnaires the importance of involving patients in the medicines development and in the acceptability method development was investigated. Questions on how best to determine palatability and swallowability were asked. The relevance of all EMA-listed acceptability elements was assessed via coloured and numbered stickers and questionnaires. Results The results showed that the involvement of young people in the medicines and acceptability method development was rated high. The group worked out that a 5-point smiley Likert Scale is preferred for assessing acceptability by 6–11 year old patients, while a Visual Analogue Scale is preferred for collecting adolescents’ opinion. The ranking of the EMA-listed acceptability elements showed that palatability and swallowability are the most relevant parameters, while colour of the medicine was rated as least relevant. These results, established face-to-face, were confirmed in a repeat of the ranking through an electronic questionnaire, completed by the participants individually and remotely, 5 weeks later. Conclusion This work reinforced the need and value to involve young people in the medicines lifecycle, and specifically in this acceptability method development. As next step other focus group meetings with more young people from different European countries are planned
European research networks to facilitate drug research in children
No full textPaediatric drug development faces several barriers. These include fragmentation of stakeholders and inconsistent processes during the conduct of research. This review summarises recent efforts to overcome these barriers in Europe. Two exemplar initiatives are described. The European Paediatric Translational Research Infrastructure facilitates preclinical research and other work that underpins clinical trials. conect4children facilitates the design and implementation of clinical trials. Both these initiatives listen to the voices of children and their advocates. Coordination of research needs specific effort that supplements work on science, resources and the policy context
Young patients’ involvement in a composite endpoint method development on acceptability for paediatric oral dosage forms
No full textInvolving children and young people in clinical research through the forum of a European Young Persons’ Advisory Group: needs and challenges
No full textRare Commons: An Innovative Social Media Platform 2.0 for Collaborative Clinical Research on Pediatric Rare Diseases
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Additional file 1 of Young patients’ involvement in a composite endpoint method development on acceptability for paediatric oral dosage forms
No full textAdditional file 1. GRIPP 2 Short form
