1,721,323 research outputs found
Pulmonary arterial hypertension associated with congenital heart disease: Recent advances and future directions
No full textCongenital heart disease (CHD), the most common inborn defect, affects approximately 1% of all newborns worldwide. Advances in its diagnosis and treatment have led to a dramatic improvement in patients' quality of life and long-term survival prospects. However, recently it has been realised that many of these patients are affected by ongoing and life-long cardiac issues, namely residual and progressive haemodynamic lesions, arrhythmia and sudden cardiac death, as well as the development of chronic heart failure and pulmonary arterial hypertension (PAH) - all of which merit tertiary care. Unfortunately, many patients with CHD are lost to follow-up, due to the assumption that their initial response to surgical and or catheter intervention in childhood led to cure. Furthermore, there are many patients with undiagnosed or unoperated CHD in the developing world coming to medical attention during adulthood. Our article focuses on advances in the management of PAH associated with CHD, a common association with an adverse impact on quality of life and survival prospects that affects approximately 10% of patients with CHD. Much of the recent progress in PAH-CHD has focused on the extreme end of the disease spectrum, namely on Eisenmenger syndrome. Herein we discuss this progress and future directions for this emerging cardiovascular field
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Mesure de la graisse épicardique par IRM et risque cardiovasculaire chez les enfants
No full textChildhood obesity is a growing public health issue. Fat distribution is an important factor, with mounting evidence that visceral adiposity is associated with the development of cardiovascular changes and diseases. Epicardial adipose tissue is a visceral fat depot associated with metabolic syndrome and coronary artery disease in adults. We report the results of a cross-sectional study including 48 obese and lean adolescents, showing a strong and significant correlation between epicardial adipose tissue volume measured by MRI and central adiposity parameters as well as cardiovascular risk factors. Moreover, epicardial fat volume is higher in obese adolescents with metabolic syndrome than in obese adolescents without metabolic syndrome. Therefore, early assessment of epicardial adipose tissue volume may help identify adolescents at increased risk of future cardiometabolic disease
Une étiologie rare de cardiomyopathie pédiatrique réversible illustrée par une présentation de cas et revue de littérature
No full textLes cardiomyopathies sont peu fréquentes en pédiatrie et le pronostic est plutôt sombre avec un taux de décès ou transplantation à 1 et 5 ans de respectivement 31% et 46%. Les cardiomyopathies dilatées représentent la première cause de transplantation cardiaque chez l'enfant. Les étiologies sont multiples et les avancées génétiques expliquent de plus en plus de cardiomyopathies auparavant inexpliquées. Malgré cela, deux tiers des cardiomyopathies sont toujours classifiées comme idiopathiques. L'étiologie sous-jacente détermine largement le pronostic et la survie. Malheureusement, les causes curables ou réversibles restent exceptionnelles
Comparaison des différentes formes de méthylphénidate dans le trouble hyperactivité avec déficit d'attention
No full textLe trouble hyeractivité avec déficit d'attention touche 5-7% des enfants en âge scolaire. Plusieurs traitements médicamenteux ont été proposés (psychostimulants tels le méthylphénidate et la dextroamphétamine), l'atomoxétine, les anti-dépresseurs tricycliques et la clonidine. En Suisse, seul le méthylphénidate, sous différentes formes galéniques, est commercialisé au moment de cette étude. Le but de cette étude était de comparer l'efficacité, la durée d'action, les effets secondaires et la satisfaction globale de deux formes retard de méthylphénidate, à savoir la Ritaline SR et le Concerta, au moyen d'un questionnaire. 72 patients sous Ritaline SR et 105 patients sous Concerta ont été inclus dans l'étude. Notre étude démontre une bonne efficacité des deux formes retard de méthylphénidate, légèrement meilleure que la Ritaline sur les symptômes d'inattention et d'hyperactivité. La durée d'action est nettement plus longue pour le Concerta (9.6 +/-3.4h) que la Ritaline SR (7.7 +/- 2.6h), ce qui a certainement contribué à la meilleure satisfaction globale pour le Concerta. Concernant les effets secondaires, le profil est similaire pour les deux formes et légèrement meilleur que la Ritaline en ce qui concerne l'effet rebond
L'épilepsie dans le syndrome de l'X fragile
No full textLe syndrome de l'X fragile (FXS) est la cause la plus fréquente de retard mental hérité. Le spectre clinique inclut des signes dysmorphiques, des particularités comportementales, et de l'épilepsie dans 23% des cas. Les crises sont rares, et de caractéristiques cliniques et électro-encéphalographiques se rapprochant de l'épilepsie à pointes centro- temporale. L'état de mal épileptique semble exceptionnel dans le FXS. Nous avons rapportés les caractéristiques cliniques, électro-encéphalographiques et radiologiques de 5 enfants FXS, qui se sont présentés en état de mal comme crise inaugurale. Les hypothèses de la propension des patients FXS aux crises épileptiques prolongées sont discutées à la lumière d'une revue de la littérature récente. Ce travail est de plus étayé par une présentation plus approfondie de l'épilepsie et du syndrome de l'X fragile
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