1,721,005 research outputs found
The imaging profile of “probable PLS”: white and grey matter measures
No full textThe recent consensus criteria for the diagnosis of primary lateral sclerosis (PLS) introduced the category of “probable PLS” for patients exhibiting upper-motor-neuron sings with a symptom duration interval of 2-4 years. These patients would have previously not met diagnostic criteria. In this dataset we present their imaging profile based on grey and white matter metrics in relevant anatomical regions in contrast to healthy controls and ‘definite PLS’ patients with over 4 years of symptom duration. The study was sponsored by the Spastic Paraplegia Foundation, Inc. (SPF), the Health Research Board (HRB EIA-2017-019), the EU Joint Programme – Neurodegenerative Disease Research (JPND), the Andrew Lydon scholarship, the Irish Institute of Clinical Neuroscience (IICN), the Iris O'Brien Foundation. Methodological details are provided in: Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of "probable PLS". Finegan E, Li Hi Shing S, Siah WF, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. J Neurol Sci. 2020 Jul 24;417:117052. doi: 10.1016/j.jns.2020.117052. Online ahead of print. PMID: 3273106
Thalamic nuclei in motor neuron disease: volumetric profiles
No full textThalamic degeneration is a recognised feature of motor neuron disease which manifest in a range of extrapyramidal motor and neuropsychological deficits. While computational neuroimaging allows the detailed characterisation of thalamic changes in vivo, existing neuroimaging studies have invariably evaluated the thalamus as a single structure. In this dataset we present the volumetric profile of specific thalamic nuclei in 100 patients with ALS, 33 patients with PLS and 117 healthy controls. T1-weighted images were acquired with a 3D Inversion Recovery prepared Spoiled Gradient Recalled echo pulse sequence with an isometric spatial resolution of 1 mm3 on a 3 Tesla MRI system. A Bayesian inference was used to segment the thalamus into specific nuclei using a probabilistic atlas. The study was sponsored by the Spastic Paraplegia Foundation, Inc. (SPF), the Health Research Board (HRB EIA-2017-019), the EU Joint Programme – Neurodegenerative Disease Research (JPND), the Andrew Lydon scholarship, the Irish Institute of Clinical Neuroscience (IICN), the Iris O'Brien Foundation. Methodological details are provided in: "Switchboard" malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Chipika RH, Finegan E, Li Hi Shing S, McKenna MC, Christidi F, Chang KM, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P. Neuroimage Clin. 2020 May 30;27:102300. doi: 10.1016/j.nicl.2020.102300. Online ahead of print. PMID: 3255432
Thalamic nuclei in motor neuron disease: volumetric profiles
No full textThalamic degeneration is a recognised feature of motor neuron disease which manifest in a range of extrapyramidal motor and neuropsychological deficits. While computational neuroimaging allows the detailed characterisation of thalamic changes in vivo, existing neuroimaging studies have invariably evaluated the thalamus as a single structure. In this dataset we present the volumetric profile of specific thalamic nuclei in 100 patients with ALS, 33 patients with PLS and 117 healthy controls. T1-weighted images were acquired with a 3D Inversion Recovery prepared Spoiled Gradient Recalled echo pulse sequence with an isometric spatial resolution of 1 mm3 on a 3 Tesla MRI system. A Bayesian inference was used to segment the thalamus into specific nuclei using a probabilistic atlas. The study was sponsored by the Spastic Paraplegia Foundation, Inc. (SPF), the Health Research Board (HRB EIA-2017-019), the EU Joint Programme – Neurodegenerative Disease Research (JPND), the Andrew Lydon scholarship, the Irish Institute of Clinical Neuroscience (IICN), the Iris O'Brien Foundation. Methodological details are provided in: "Switchboard" malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Chipika RH, Finegan E, Li Hi Shing S, McKenna MC, Christidi F, Chang KM, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P. Neuroimage Clin. 2020 May 30;27:102300. doi: 10.1016/j.nicl.2020.102300. Online ahead of print. PMID: 3255432
The imaging profile of “probable PLS”: white and grey matter measures
No full textThe recent consensus criteria for the diagnosis of primary lateral sclerosis (PLS) introduced the category of “probable PLS” for patients exhibiting upper-motor-neuron sings with a symptom duration interval of 2-4 years. These patients would have previously not met diagnostic criteria. In this dataset we present their imaging profile based on grey and white matter metrics in relevant anatomical regions in contrast to healthy controls and ‘definite PLS’ patients with over 4 years of symptom duration. The study was sponsored by the Spastic Paraplegia Foundation, Inc. (SPF), the Health Research Board (HRB EIA-2017-019), the EU Joint Programme – Neurodegenerative Disease Research (JPND), the Andrew Lydon scholarship, the Irish Institute of Clinical Neuroscience (IICN), the Iris O'Brien Foundation. Methodological details are provided in: Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of "probable PLS". Finegan E, Li Hi Shing S, Siah WF, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. J Neurol Sci. 2020 Jul 24;417:117052. doi: 10.1016/j.jns.2020.117052. Online ahead of print. PMID: 3273106
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
