171,217 research outputs found
Beckwith, A. C. stock farm
No full textA. C. Beckwith Uinta Stock Farms. "Here is a picture of Grandpa Beckwith\u27s place at its prime with 2 horses that held the world record at that time." --Frank A. Beckwith. (Location: Uinta County, Wyoming, near Evanston
Beckwith house
No full textThe Beckwith (Frank A. & Mary A. Simister) home at 167 C St. Salt Lake City, Uta
Beckwith, Mary Ernestine Stuart Rose
No full textMary Ernestine Stuart Rose Beckwith, wife of A. C. Beckwith. Born October 22, 1839 in Madison, Lake, Ohio. Died November 18, 1894 in Evanston, Wyomin
Letter from Beckwith to Schumann
No full textLetter dated 18 January 1856 from Lieutenant E. G. Beckwith to C. Schumann, who prepared illustrations for the 1854 report on the E. G. Beckwith expedition.Introductio
Genomic imprinting defects in the growth disorder Beckwith-Wiedemann syndrome
No full textThe imprinting control region (IC1) of the human IGF2 and H19 genes is represented by a chromatin insulator located between the two genes that prevents the activation of IGF2 and allows the activation of H19 on the maternal chromosome. Deletions removing part of IC1 have been found in patients affected by the overgrowth- and tumour-associated Beckwith–Wiedemann syndrome (BWS). These mutations result in the hypermethylation of the remaining IC1 region and loss of IGF2/H19 imprinting. However, other IC1 microdeletions are associated with incompletely penetrant phenotypes and do not affect the methylation of the locus. Our results indicate that the mutant IC1 alleles with abnormally longer cluster of sites for CTCF have reduced affinity for this factor with respect to the alleles with spacing similar to the wild type sequence, suggesting that the organization rather than the number of CTCF sites in the deleted alleles is critical for the gain of methylation and loss of insulator function. Furthermore, a detailed methylation analysis of BWS patients with IC1 hypermethylation and no accompanying deletion showed that the abnormal methylation is mosaic in the majority of the cases and can affect either the entire or only the 3’ half of the regulatory region. In these cases, the epimutation and the phenotype did not cosegregate with the 11p15.5 region. In both the cases with the microdeletions and those without sequence change, the epigenetic abnormalities are usually present in the patients in the mosaic form and probably acquired by post-zygotic de novo methylation
Topaz Oral History Project miscellaneous interviews: Jane Beckwith material
No full textA set of materials from Jane Beckwith of the Topaz Museum, Delta, Utah, including transcripts of interviews with those who worked at Topaz internment camp, copies of published articles, and correspondence between Jane Beckwith and othersA copy of a talk given to Weber High School students regarding some of my recollections about Topaz, Utah, a war relocation center, by Dorothy B. Pratt, April 1983 (typescript, 4 pages); Interview about Topaz relocation center, Sherm Tolbert, interviewed by George Henrie, student of Jane Beckwith, Spring 1983 (typescript, 12 pages); Central Utah war relocation project, Topaz Center, 1942 - 1945, by Yasuo Wm. Abiko (typescript, 5 pages); Interview of Homer U. Petersen, May 1983, Delta, Utah [interviewed by Jane Beckwith] (typescript, 4 pages); Evelyn Okamoto memories of Topaz (typescript, 1 page, incomplete); Millard County Chronicle articles on Topaz internment center, 1942, 1943; "Model" newsletter from Delta High School, issue 3 (March 9, 1983), with various articles about Topaz (4 pages); Letter to Jane Beckwith from July 1987 (author uncertain
John K. Jack Beckwith Interview, April 16, 1985
No full textJohn “Jack” Beckwith discusses his family history and their connections to C. H. McLeod and A. B. Hammond. He talks about the Missoula Mercantile Company, growing up in St. Ignatius, and life during the 1920s and during the Depression and its effects on the Flathead Indian Reservation. Beckwith also discusses the building of the irrigation system for Flathead valley, Robert Watt, and the relationship between his grocery store and the McLeods. He ends the tape by discussing his life in Great Falls and the street in Missoula named after his father.https://scholarworks.umt.edu/depressioninmissoula_oralhistory/1002/thumbnail.jp
Clark, Mr. C.D.
No full textMr. C.D. Clark 1885. Photo by C. D. Kirkland Cheyenne, Wyoming. Mr. Clark became a senator. He is buried near A. C. Beckwith, father of Frank A. Beckwith. An older photo owned by the Beckwith famil
Methylation analysis and diagnostics of Beckwith-Wiedemann syndrome in 1,000 subjects
No full textBackgroundBeckwith-Wiedemann syndrome (BWS), a congenital overgrowth disorder with variable expressivity and a predisposition to tumorigenesis, results from disordered expression and/or function of imprinted genes at chromosome 11p15.5. There are no generally agreed clinical diagnostic criteria, with molecular studies commonly performed to confirm diagnosis. In particular, methylation status analysis at two 11p15.5 imprinting control centres (IC1 and IC2) detects up to 80% of BWS cases (though low-level mosaicism may not be detected). In order to evaluate the relationship between the clinical presentation of suspected BWS and IC1/2 methylation abnormalities we reviewed the results of >1,000 referrals for molecular diagnostic testing. ResultsOut of 1,091 referrals, 507 (46.5%) had a positive diagnostic test for BWS. The frequency of tumours was 3.4% in those with a molecular diagnosis of BWS. Previously reported genotype-phenotype associations with paternal uniparental disomy, IC1, and IC2 epimutation groups were confirmed and potential novel associations detected. Predictive values of previously described clinical diagnostic criteria were compared and, although there were differences in their sensitivity and specificity, receiver operating characteristic (ROC) analysis demonstrated that these were not optimal in predicting 11p15.5 methylation abnormalities. Using logistic regression, we identified clinical features with the best predictive value for a positive methylation abnormality. Furthermore, we developed a weighted scoring system (sensitivity 75.9%, and specificity 81.8%) to prioritise patients presenting with the most common features of BWS, and ROC analysis demonstrated superior performance (area under the curve 0.85, 95% CI 0.83 to 0.87) compared to previous criteria. ConclusionsWe suggest that this novel tool will facilitate selection of patients with suspected BWS for routine diagnostic testing and so improve the diagnosis of the disorder. <br/
Beckwith, C M (Cecil Melvin), SX10995
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/370974Surname: BECKWITH
Given Name(s) or Initials: C M (CECIL MELVIN)
Military Service Number or Last Known Location: SX10995
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 31181181329
Item: [2016.0049.03301] "Beckwith, C M (Cecil Melvin), SX10995
- …
