326 research outputs found
Film juvenile Jorg Becker.
No full textFilm juvenile Jorg Becker.To order a reproduction, inquire about permissions, or for information about prices see:
http://www.lib.washington.edu/specialcollections/services/reproduction/reproduction
Please cite the Order NumberScanned at 600ppi with an Epson 20000 flatbed scanner. Image then rotated, cropped, level-adjusted, and sharpened using Photoshop CS3. Converted to a JPEG2000 image upon ingest into CONTENTdm
Epigenomic technologies: an interview with Jorg Tost
No full textInternational audienceJörg Tost received his PhD in genetics from the University of Saarbrücken (Germany) in 2004 for devising novel methods for the analysis of haplotypes and DNA methylation patterns. After a postdoctoral stay in the technology development department of the Centre National de Génotypage (Evry, France), he led the Epigenetics groups from 2006 to 2012, before becoming the Director of Laboratory for Epigenetics and Environment at the Centre National de Recherche en Génomique Humaine (CNRGH). The laboratory is involved in the development and application of technologies to analyze DNA methylation, miRNAs and other epigenetic modifications quantitatively at high resolution at target loci and genome-wide using state-of-the-art sequencing technologies as well as the development of bioinformatic tools for the processing of such data. The laboratory mainly focuses on the analysis of epigenetic changes in neurodegenerative, autoimmune and inflammatory diseases as well as the alteration of the epigenetic profiles in function of environmental exposure. A second research axis investigates novel technologies for the analysis of mutations of clinical relevance present at very low proportions in the analyzed samples and their impact on treatment management. Tost has an H-index of 50 and is the author or co-author of more than 195 publications
How does Creativity Impact Business Processes?
No full textBusiness processes that involve creativity differ from conventional business processes in many respects: they have a low level of repeatability, typically are high value-add processes, are knowledge-intensive, involve creative persons, have a high demand for flexibility and are characterized by particular (creative) risks. Consequently, for the IS discipline there arise a couple of research questions in this context. The goal of this interpretive research is to develop a theory of creativity-intensive processes that can inform organizational design and the design of information systems. The central theme of this research is the awareness that creativity must be perceived as a part of business processes – that is, part of goal-oriented acting within an organization that comprises of both creative and non-creative activities. In this paper, we introduce an initial model of the creativity-intensive process based on a qualitative exploratory study. To do so, we introduce research method and concepts as well as relationships and interactions between concepts. With this paper we aim to motivate further research on the impact of creativity on business processes and business process management within the IS discipline
Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity
No full textInducible epigenetic changes in eukaryotes are believed to enable rapid adaptation to environmental fluctuations. We have found distinct regions of the Arabidopsis genome that are susceptible to DNA (de)methylation in response to hyperosmotic stress. The stress-induced epigenetic changes are associated with conditionally heritable adaptive phenotypic stress responses. However, these stress responses are primarily transmitted to the next generation through the female lineage due to widespread DNA glycosylase activity in the male germline, and extensively reset in the absence of stress. Using the CNI1/ATL31 locus as an example, we demonstrate that epigenetically targeted sequences function as distantly-acting control elements of antisense long non-coding RNAs, which in turn regulate targeted gene expression in response to stress. Collectively, our findings reveal that plants use a highly dynamic maternal ‘short-term stress memory’ with which to respond to adverse external conditions. This transient memory relies on the DNA methylation machinery and associated transcriptional changes to extend the phenotypic plasticity accessible to the immediate offspring
- …
