97 research outputs found
Die Zyklin-abhängigen Kinasen 19 und 8 (CDK19/8) und weitere prognostische Biomarker im Prostatakarzinom
No full textFrom iconic to overlooked species: How (electronic) tags improve our understanding of marine ecosystems and their inhabitants
No full textNo abstracts are to be cited without prior reference to the author.Conveners: Matthias Schaber (Germany), Derke Snodgrass (USA).CM 2017/D:471. Who ate my science project...twice?. Matthias Schaber, Heino Fock, Péricles Neves SilvaCM 2017/D:354. If you can’t beat them, eat them: using acoustic telemetry to develop an economically viable fishery for the highly invasive roundgoby (Neogobius melanostomus). Mads Christoffersen, Jon C. Svendsen Jane Behrens Niels Jepsen Mikael van DeursCM 2017/D:322. Coupling spectral analysis and Hidden Markov Models for the segmentation of behavioural patterns: European sea bass as astudy case. Mathieu Woillez, Karine Heerah, Ronan Fablet, François Garren, Stéphane Martin, Hélène De PontualCM 2017/D:323. Comparison of geolocation models for the analysis of the spatial dynamics and population structure of pelagic fish: application toEuropean sea bass (Dicentrarchus labrax). Serena Wright, Mathieu Woillez, Victoria Bendall, Karine Heerah, David Righton, Ewan Hunter, Hélène de PontuaCM 2017/D:155. Movement and diet: Individual specialisations of barbel Barbus barbus in a disconnected and subsidised world. Catherine Gutmann Roberts, Andrew Hindes Robert BrittonCM 2017/D:477. Fine and broad-scale movement ecology of yellowtail snapper Ocyurus chrysurus within a marine protected area in the U.S. Virgin Islands. Ashleigh Novak, Sarah Becker, Jack Finn, Clayton Pollock, Zandy Hillis-Starr, Adrian JordaanCM 2017/D:315. Using acoustic telemetry to monitor competitive interactions between European Seabass (Dicentrarchus labrax) and giltheadseabream (Sparus aurata) in Salcombe Harbour, UK. Jenifer Lewis, Thomas Stamp, Ewan Hunter, Tim Robbins, Libby Ross, Frank van Veen, Emma SheehanCM 2017/D:286. Project I-BASS (preliminary results): Using acoustic telemetry to measure the effectiveness of spatial management for EuropeanSeabass (Dicentrarchus labrax). Thomas Stamp, Shaun Plenty, Tim Robbins, Libby Ross, Emma SheehanCM 2017/D:526. Lobster and crab movement around salmon farms in New Brunswick, Canada. Christopher W. McKindsey, Rénald Belley, Annick Drouin, Shawn M. C. Robinson, Émilie SimardCM 2017/D:517. IGFA Great Marlin Race: Largest citizen science billfish satellite tagging project. Leah Baumwell, Jason SchratwieserCM 2017/D:596. Northern Fur Seals and Pollock in the Eastern Bering Sea. Ivonne Ortiz, Jeremy SterlingCM 2017/D:339. A GPU-accelerated particle filter geolocation method for demersal fish using archival tagging data. Chang Liu, Chang Liu, Geoffrey CowlesCM 2017/D:381. Acoustic tags reveal the influence of electromagnetic fields on migratory and electro-sensitive species in an in situ controlled mesocosm study. Zoe L Hutchison, Andrew B. Gill, Peter Sigray, John King</p
Round-robin study on the determination of weld geometry parameters—part B : analysis of welded specimen
No full textPublisher Copyright: © The Author(s) 2025.The local geometry of the weld toe or the weld seam has a high influence on the fatigue strength of welded joints. Two main parameters for the geometrical description of the weld toe are the weld toe radius and the weld toe angle. Currently, there is no uniform definition or standardized measurement approach for the assessment of these parameters. For this reason, the presented extensive round-robin (RR) study focusses on the influence of different evaluation techniques and measurement systems regarding the mentioned parameters based on 3D surface scans. In total, 20 participants take part in this two stage RR (19 participants in the second part). In this work, the results of the second part (part B) of the RR, namely the evaluation of weld toe radius and weld toe angle on real welded joints, are presented, where the actual weld toe geometry is not known a priori. For this, 22 data sets were evaluated. The data sets consist of measured values for the radius and angle of the weld toe in relation to the position along the weld seam. In general, significant variations are determined for the evaluated weld geometry parameters, especially for the weld toe radius. It is also shown that the condition of the weld toe transition has a high influence on the parameter. Particularly for weld seams with a low weld toe angle, the measurement results for the radius of the individual participants show high variations. For small weld toe radii, the results are quite comparable between the participants. The results for the weld toe angle are comparable for flat welds, but a wide range of results is observed for sharp weld toes. The degree of automation of the measurement method also has a high influence on the results. The most accurate results are expected from manual measurements, while the fully automatic and semi-automatic methods show larger deviations.Peer reviewe
The Baby Boom and Baby Bust
No full textWhat caused the baby boom? And, can it be explained within the context of the secular decline in fertility that has occurred over the last 200 years? The hypothesis is that: 1. The secular decline in fertility is due to the relentless rise in real wages that increased the opportunity cost of having children. 2. The baby boom is explained by an atypical burst of technological progress in the household sector that occurred in the middle of the last century. This lowered the cost of having children. A model is developed in an attempt to account, quantitatively, for both the baby boom and bust.Baby boom, fertility, technological progress
Regulation of the mTOR/S6K pathway by cellular energy
No full textThe mammalian target of rapamycin (mTOR) signaling pathway integrates positive and negative signals that control cellular growth, metabolism and survival. mTOR exists in two different complexes, mTOR Complex1 and mTOR Complex2. mTOR Complex1, which is rapamycin-sensitive, phosphorylates ribosomal S6 kinase 1 (S6K1) and initiation factor 4E binding proteins (4E-BPs). mTOR Complex2, which is rapamycin-insensitive, phosphorylates and activates protein kinase B (PKB/Akt). Both mTOR complexes are stimulated by mitogens, but only mTOR Complex1 is under the control of nutrients and cellular energy status. With respect to cellular energy status, mTOR Complex1 signaling is sensitive to inhibition of both glycolytic flux and mitochondrial oxidative phosphorylation. In brief, energy deprivation affects mTOR Complex1 through two routes: an acute rapid response and a chronic long lasting response. Here we describe the mechanisms by which energy depletion influences mTOR Complex1 signaling, largely focusing on the acute response. Previous studies, mainly based on correlative evidence, argued that the acute energy deprivation response is mediated by adenosine mono phosphate-dependent protein kinase (AMPK) through the activation of the tumor suppressor, Tuberous Sclerosis Complex 1 and 2 (TSC1/2). We used specific knockout cell lines to address this issue and, unexpectedly, found that TSC1/2, recognized as a point of convergence for a number of specific signals, is dispensable for the regulation of mTOR Complex1 by acute energy depletion. Strikingly, neither the inhibitory acute nor the chronic energy-deprivation response towards mTOR Complex1 requires AMPK. Moreover, the upstream activator of AMPK, the serine/threonine protein kinase 11 (STK11/LKB1) is also dispensable for the acute energy depletion response to mTOR Complex1 signaling. The results demonstrate that acute energy depletion signals operate independently of the LKB1-AMPK-TSC2 axis on mTOR Complex1, revealing a novel autonomous energy-dependent mTOR Complex1 signaling pathway. Importantly, we find that metformin, a widely prescribed drug for the treatment of diabetes mellitus type II, which is thought to operate through the LKB1-AMPK-TSC2 axis, affects mTOR Complex1 signaling through this same autonomous energy-dependent pathway, independent of AMPK and TSC. The significance of these findings is underscored by recent clinical studies showing that patients using metformin have a lower incidence of tumor development
The Degree of Openness to Intra-Regional Trade - Towards Value-Added Based Openness Measures
No full textDo Social Policies Harm Employment and Growth?
No full textIn economies with competitive labour markets social policies harm employment and output. In Europe, in particular, non-competitive labour markets with trade unions, efficiency wages and/or costly search and mismatch seem more realistic. Social policies such as progressive taxation or facilitating corporatism may well induce wage moderation and boost employment and output. Although unconditional unemployment benefits destroy jobs, conditional benefits may spur job growth. In a second-best world usual effects of social policies are thus overturned. In addition, the incidence of taxation and the effects of tax progressivity depend crucially on the specific features of the welfare state, e.g., whether benefits are indexed to wages or not. In a full political-economic equilibrium a more equitable distribution of income and assets leads to a median voter who is better off and thus votes for less 'populist' policies. Hence, employment and economic growth will be higher and inflation lower. In general the supremacy of 'laisser faire' is questioned also by international comparisons.social policies, conditional unemployment benefits, non-competitive labour markets, employment, growth, politics
(How) Do Stock Market Returns React to Monetary Policy? - An ARDL Cointegration Analysis for Germany
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