1,720,965 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Toxicity of microcystin-LR in hepatocytes and non-hepatocytes in vitro
No full textMicroystin-LR (MCLR), a cyanobacterial heptapeptide is an inhibitor of protein phosphatases 1 and 2A (PPs), a potential tumor promoter in rat liver, and selectively toxic to the liver in vivo and isolated hepatocytes in vitro. Inhibition of PPs has been linked to excessive phosphorylation and collapse of intermediate filaments (IFs) in hepatocytes. MCLR was used as a probe to understand the mechanism of action of this toxin in hepatocytes and non-hepatocytes.Cultured rat skin fibroblasts and rat kidney epithelial cells were incubated with MCLR at 133 pM for 1 to 24 hr. Pathologic changes, or cytoskeletal changes in IFs, microtubules (MTs), and microfilaments (MFs) at the light and ultrastructural levels in these cells were compared with those in cultured hepatocytes incubated with MCLR at 13.3, 1.3, or 0.13 pM from 1 to 32 min. Changes in a 58 kDa microtubule associated protein, MTs, and IFs in hepatocytes incubated with MCLR at 13.3, 1.3, or 0.13 pM were characterized. Lesions in all three cell types included: plasma membrane blebbing, loss of cell-to-cell contact, clumping and rounding of cells, cytoplasmic vacuolization, and redistribution of cytoplasmic organelles. Loss of microvilli, whorling of rough endoplasmic reticulum, dense staining and dilated cristae in mitochondria, and pinching off of membrane blebs were noted only in hepatocytes. Nuclear changes typical of apoptosis were observed only in fibroblasts and kidney cells.Made available in DSpace on 2011-05-07T13:15:55Z (GMT). No. of bitstreams: 2
license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5)
9503231.pdf: 6068665 bytes, checksum: 19305e859d6102e07358e8957591861d (MD5)
Previous issue date: 1994Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2011-05-07T14:52:28Z
Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:24:10-05:00
Original Data
Group with Access UIUC Users [automated]
Release Date: none
Reason: ETDs are only available to UIUC Users without author permissionETDs are only available to UIUC Users without author permissionU of I Onl
Structure/toxicity relationships and fate of low molecular weight peptide toxins from cyanobacteria
No full textHepatic glutathione (GSH) was depleted to assess the influence of GSH on the toxicity of MCYST-LR in vivo. The GSH conjugate of MCYST-LR was also formed synthetically. There was an approximately four-fold decrease in the toxicity of the GSH derivative, as compared to the parent toxin; but the GSH conjugate remained hepatotoxic and hepatospecific in its effects.Sodium borohydride-induced structural manipulation of the dehydro amino acids of two different cyanobacterial peptides, MCYST-LR and nodularin, resulted in selectively saturated dihydro products. The dihydro products were compared with the parent toxins in toxicity trials in order to assess the role of the dehydro amino acid units in the toxicity.Tritium-labeled sodium borohydride was used to produced tritium-labeled 2H-MCYST-LR. The labeled toxin was administered intraperitoneally to male mice in lethal (200 g/kg) or sublethal (100 g/kg) doses, and the organ distributions measured over a 60 min observation period. Sublethal (100 g/kg) doses were also administered to a second group of mice and the excretion of radioactivity in urine and feces was measured at 12 hr intervals for 72 hr, along with tissue distribution at the end of the observation period. Accumulation of labeled toxin in the livers of treated animals was rapid with 94.7 3.3% (mean S.D.) of the sublethal dose present in the liver after 1 hr, and 57.8 5.2% of the administered dose present 72 hr after administration. The small intestine also accumulated radioactivity in both treatment groups. Excretion of the toxin in sublethally dosed animals occurred primarily via the feces.The structure/toxicity relationships of functional substituents of microcystin-LR and nodularin were investigated. The unusual C\sb{20} amino acid associated with all cyanobacterial peptide hepatotoxins described to date was synthesized its toxicity tested in vivo. Derivatives of the toxin which resulted in alteration of the ADDA substituent had reduced toxicity.Made available in DSpace on 2011-05-07T12:21:16Z (GMT). No. of bitstreams: 2
license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5)
8924800.pdf: 8182142 bytes, checksum: 29617c8eca92e818e204fcf0c1231fec (MD5)
Previous issue date: 1989Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2011-05-07T14:39:59Z
Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:16:59-05:00
Original Data
Group with Access UIUC Users [automated]
Release Date: none
Reason: ETDs are only available to UIUC Users without author permissionETDs are only available to UIUC Users without author permissionU of I Onl
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
The toxicity of microcystin-LR in swine and mice
No full textMicrocystin-LR (MCLR) is a monocyclic heptapeptide hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. One gilt given whole M. aeruginosa cells ig containing 0.3% MCLR and des-methyl MCLR at 2.1 g/kg had severe panlobular hepatic necrosis and hemorrhage when euthanatized at 32.5 hr postdosing.Mean liver and kidney weights increased 50-64% and 20-32%, respectively, in two strains of male mice that died within 200 minutes after a single lethal ip dose of purified MCLR. Mice that survived an ip LD\sb{23} or LD\sb{30} of MCLR had significantly longer survival times and higher survival rates when given an approximate ip LD\sb{100} minimum (40-75 g/kg) 2 or 3 days later.The liver (34.01 IU/g), pancreas (5.43 IU/g), and kidney (3.24 IU/g) were the only swine tissues with mean arginase activity (ARG) greater than 0.52 IU/g. The serum t of ARG in a barrow and gilt were 85.8 and 128.0 minutes (min).Between 12 and 24 min after anesthetized gilts were given a lethal iv dose of purified MCLR (72 g/kg), mean aortic and central venous pressures, and renal and hepatic perfusion decreased () significantly, while portal venous pressure increased () significantly. Significant changes at 45 min included bile acids, total bilirubin, lactate, K, and pO\sb2, and platelet count, base excess, Hct, HCO\sb3-, and pCO\sb2. At 90 min, significant changes included ARG, P, BUN, and creatinine, and pH and glucose. Significant changes 150 min postdosing included AST, AP, ALT, CPK, and LDH. Livers were markedly enlarged, dark purple-red in color, and readily exuded blood on cut surfaces. Significantly liver weights and liver Fe and Hb concentrations were suggestive that 37.9% of the estimated blood volume was present in the liver. The major cause of acute death (5 hr) following iv MCLR dosing in swine is hypovolemic shock which results from massive intrahepatic hemorrhage.Made available in DSpace on 2011-05-07T12:21:55Z (GMT). No. of bitstreams: 2
license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5)
9010942.pdf: 9195790 bytes, checksum: f70b45b44c56c28261445a5da040314c (MD5)
Previous issue date: 1989Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2011-05-07T14:40:07Z
Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:17:06-05:00
Original Data
Group with Access UIUC Users [automated]
Release Date: none
Reason: ETDs are only available to UIUC Users without author permissionETDs are only available to UIUC Users without author permissionU of I Onl
- …
