41 research outputs found
İktidarın ortaya attığı düşmanlık
No full textTaha Toros Arşivi, Dosya No: 81-Celal Bayar.
Not: Metin ekli dokümanın 7. sayfasında yer almaktadır
İktidarın kıl kuyrukları büyük bir ümide düşmüşlerdir
No full textTaha Toros Arşivi, Dosya No: 81-Celal Bayar.
Not: Metin ekli dokümanın 4. sayfasında yer almaktadır
Inflammasome activation, colonic cancer and glucose metabolism
No full textObjectives: To study the association between inflammasome activation (a potent initiator of inflammation acting via caspase-1 and maturation of interleukin-1β), colonic cancer and glucose metabolism.Methods: Five patients with colon cancer and ten matched controls without cancer were measured for insulin sensitivity using the hyperinsulinemic euglycemic clamp. For detection of inflammasome activation the caspase-1 activity, determined by detecting FLICA using flow cytometry, was measured in both monocytes and granulocytes at the start of, and at 120 minutes into the clamp. Descriptive and analytical statistics were performed using nonparametric methods by SPSS.Results: There was no difference in levels of insulin sensitivity between the two groups (p=0.09). The cancer patients had significantly lower levels of caspase-1 both in monocytes (p<0.05) and granulocytes (p<0.05) compared with the controls. However both patients and controls had significantly higher levels of both mono- and granulocyte caspase-1 activity at 120 minutes into the clamp as compared to at start (p<0.05). Patients showed an overall higher relative increase in caspase-1 during the clamp, however this finding did not reach statistical significance (monocytes; p=0.27, granulocytes; p=0.22).</p
Insulin resistance and inflammation in open versus minimally invasive colorectal cancer surgery in ERAS
No full textTotal Mesorectal Excision for Mid-Rectal Cancer Without Anastomosis : Low Hartmann's Operation or Intersphincteric Abdomino-Perineal Excision?
No full textBACKGROUND AND AIMS: In mid-rectal cancer, the low colorectal anastomosis is, although feasible, sometimes avoided. The aim was to compare low Hartmann's procedure with intersphincteric abdomino-perineal excision of the rectum, in patients operated with total mesorectal excision for mid-rectal cancer in whom the low anastomosis was technically feasible but for patient-related reasons undesired.MATERIAL AND METHODS: A total of 64 consecutive patients with mid-rectal cancer who underwent low Hartmann's procedure (n = 34) or intersphincteric abdomino-perineal excision (n = 30) at one colorectal unit were compared regarding patient demography, short-term oncology, surgical outcome at 3 and 24 months, and long-term overall survival.RESULTS: There were no significant differences between intersphincteric abdomino-perineal excision and Hartmann's procedure regarding age, gender distribution, body mass index, preoperative radiotherapy, tumor level, or cancer stages. Operation time was shorter in Hartmann's procedure as compared with intersphincteric abdomino-perineal excision, median 174 and 256 min, (P < 0.001), and intraoperative blood loss was increased, 600 and 500 mL, respectively (P = 0.045). Number of lymph nodes and circumferential resection margin were comparable. In Hartmann's procedure compared with intersphincteric abdomino-perineal excision, the need for reoperation was 24% and 3%, (P = 0.020), complications classified as Clavien-Dindo 3-4 occurred in 32% and 10%, (P = 0.031), pelvic abscess in 21% and 10%, (P = 0.313), and mortality within 90 days was 3% and 0%, respectively, (P = 0.938). In intersphincteric abdomino-perineal excision, the perineal wound was not healed at 3 months in 13%, and in Hartmann's procedure 15% had chronic secretion from the anorectal remnant at 2 years postoperatively.CONCLUSION: The results from this study suggest that intersphincteric abdomino-perineal excision might be an alternative to Hartmann's procedure in patients with mid-rectal cancer, in whom a low colorectal anastomosis is undesired.</p
Determination of insulin resistance in surgery : the choice of method is crucial
No full textBACKGROUND & AIMS: In elective surgery, postoperative hyperglycaemia and insulin resistance are independent risk factors for complications. Since the simpler HOMA method has been used as an alternative to the hyperinsulinemic normoglycemic clamp in studies of surgery induced insulin resistance, we compared the two methods in patients undergoing elective surgery.METHODS: Data from 113 non-diabetic patients undergoing elective surgery were used. Insulin sensitivity, both before and after surgery, was quantified by the clamp and HOMA. Pre- and postoperatively, the results of the clamp were compared to HOMA using regression- and correlation analysis. Degree of agreement between the methods was studied using weighted linear kappa and the Bland-Altman test.RESULTS: Both the clamp and HOMA recorded a mean relative reduction in insulin sensitivity of 39 ± 24% and 39 ± 61% respectively after surgery; with significant correlations (p < 0.01) for pre- and post-operative measures as well as for relative changes. However r(2) values were low: 0.04, 0.07 and 0.03 respectively. The degree of agreement for the relative change in insulin sensitivity using the Bland-Altman test gave a mean of difference 0% but "limits of agreement" (±2SD) was ±125%. This poor inter-method agreement was consolidated by a weighted linear kappa value of 0.18.CONCLUSION: While the hyperinsulinemic euglycemic clamp measures the postoperative changes in insulin sensitivity, HOMA measures something different. Data using the HOMA method must therefore be interpreted cautiously and is not interchangeable with data obtained from the clamp.</p
Insulin sensitivity in moderately severe to acute severe ulcerative colitis
No full textBACKGROUND: Patients hospitalized with moderately severe or acute severe ulcerative colitis (UC) may experience metabolic disturbances, including alterations in insulin resistance due to inflammation and the administration of glucocorticoids (GCs). This pilot study aimed to evaluate insulin sensitivity in patients hospitalized for moderately severe to severe UC.METHOD: Patients hospitalized for moderately-severely active UC at Örebro University Hospital, Sweden, were eligible for inclusion. Quantification of insulin sensitivity was performed using the hyperinsulinemic euglycemic clamp (HEC) methodology. Assessment of insulin sensitivity was performed during both the index flare and while patients were in steroid-free clinical, biochemical and endoscopic remission during follow-up. Additionally, healthy controls were evaluated using HEC for comparison.RESULTS: Five patients with moderately-severely active UC, treated with intravenous GCs for ≥2 days, were included and underwent HEC assessment. During the index flare, four patients received second-line treatment with infliximab due to non-response to GC, and one patient was subsequently referred for acute subtotal colectomy. At inclusion, all five patients exhibited significantly reduced insulin sensitivity, and levels appeared similar regardless of the outcome of the index flare. At remission during follow-up, the insulin sensitivity was restored to levels comparable to healthy controls (n = 5).CONCLUSION: The study demonstrates that patients with moderately severe to severe UC experience significant insulin resistance, irrespective of the outcome of the flare. The reduced insulin sensitivity is likely driven by a combination of active inflammation and GC treatment, as insulin sensitivity returned to normal levels when patients achieved remission during follow-up.</p
Mah Sharaf Khanoum Ardalani (Mastura Kurdistani), historian and author(1805- 1847); her life and her epoch
No full textماهشەرەفخانم بە هۆی ئەو پەروەردەیەی لەلایەن خێزانەکەیەوە هەیبووە و ئەو پێگە گرنگەی باوک و باپیری و هەردوو بنەماڵەی دایک و باوکی هەیانبوو، کەسایەتییەکی خوێندەوار و هوشیاری لێ دروستبووە؛
لە میرنشینی ئەردەڵان و شاری سنەی پایتەختیدا، وەک مەڵبەندێکی خوێندەواریی و ڕۆشنبیریی، چ ئایینی و چ زانستی مێژووناسیی، لەپاڵ بوونی بناغەیەکی گەورە و پتەودا، کۆمەڵێک مێژوونووس و بیرمەندی گەورە هەبوون، کە کاریان لەسەر هزر و دنیابینیی ماهشەرەفخانم کردووە؛
ماهشەرەفخانم بە گەواهی زۆر لە کوردناسان، تەنیا مێژوونووسی ئافرەتی ڕۆژهەڵاتی ناوەڕاستی سەدەی نۆزدەیەم و یەکەمین ئافرەتیشە، کە لەو سەردەمەدا سەرباری شاعیرێتی، لە بواری زانستە ئیسلامییەکانیشدا شارەزایی هەبووە و بەرهەمی نایابی لە دوای خۆی بەجێهێشتووە؛
دەسەڵاتدارانی ئێران بەتایبەتی لە سەرەتای سەدەی نۆزدەیەمەوە لەڕێگەی ژنوژنخوازییەوە، توانیان هەژموونی خۆیان و پرۆسەی بەشیعەکردنی کوردی ئەردەڵان چڕتر بکەنەوە و کاتێک بەرهەڵستیان بۆ دروستبوو، ڕاستەوخۆ دەستیان بەسەر میرنشینی ئەردەڵاندا گرت و پاش ماوەیەکیش بە تەواوی هەڵیان وەشاندەوە؛
میرنشینی ئەردەڵان، وەک بەشێک لە کوردستانی باشوری ڕۆژهەڵات، بێجگە لەوەی هەر لەو ناوچانەدا سەری هەڵداوە، کە دواتر بۆ ماوەی دوو سەدە لەژێر قەڵەمرەویی میرنشینی باباندا بووە، و ماوەیەکی زۆریش ململانێ لەنێوان هەردوو میرنشییەکەدا دروستبووە و خاکی یەکتریان داگیرکردووە، بەڵام بەپێچەوانەی خواستی داگیرکەرانی کوردستانەوە، لە کۆتایی سەدەی هەژدەیەم و نۆزدەیەمدا نزیکبوونەوەیەکی زۆر و خزمایەتیی و تێکەڵیەکی هەمەلایەنە لەناویاندا دروستبووە، هەر بۆیە لە کاتی لیقەوماندا پەنایان بۆ یەکتر بردووە. دواجاریش، کە خۆری ماڵباتی ئەردەڵان بەرەو ئاوابوون دەچێت، ماهشەرەفخانم و چەند هەزار کەسێکی تر ئەردەڵان بەجێ دەهێڵن و لە پایتەختی باباندا پێشوازیی گەرمیان لێ دەکرێت.Mahsharaf - Khanom became an educated and conscious person thanks to the education she received from her family and also a position that her parents and grandparents had on both sides of the parents.
In Ardalan and its capital, Sanandaj, as a center for the development of culture and education, Islamic and historical, in addition to a strong base, a large group of historians and intellectuals was found that significantly influenced Mahsharaf-Khanom's thought and consciousness.
Mahashraf-Khanom, by recognition of many the researchers , was the only female historian in the Middle East in the 19th century. She was the only woman in the period who, along with the author of poems, practiced Islamic studies with great ability and had writings and compositions.
In the beginning of the 19th century, the Iranian authorities, in particular, influenced the Ardalanian Kurds and changed their Sunni sect to Shia al-Jaafari. When they felt resistance, they imposed their authority and took control of the government directly in the emirate. They briefly removed it from existence. The Emirate of Ardalan, as part of the South - East Kurdistan, in addition to it was formed in areas, which later became under the control of the Emirate of Baban for more than two centuries, and became the source of disputes and conflicts between them and it came to the occupation of the land and cities, but despite the oppression of the Occupiers of Kurdistan, especially at the end of the 18-th century and the beginning of the 19-th century, there was a strong convergence and diverse integration among the population of the both Emirates and even the ruling class. Finally, when the dyanasty of Ardalan went to fall, Mahsharaf-Khanom and a few thousand Ardalanis moved to the capital of the Emirate of Baban, where they were received with great hospitality
Recurrent refractory Clostridium difficile colitis treated successfully with rifaximin and tigecycline: A case report and review of the literature
No full textClostridium difficile colitis infection is on the rise and is considerably increasing the duration of hospital stay, as well as healthcare costs. The management of C. difficile colitis has become more challenging with the increasing failure of therapeutic response to metronidazole and oral vancomycin. Tigecycline is a new glycylcycline that has shown in vitro activity against C. difficile. We report herein a case of C. difficile colitis that failed to improve on a combination of metronidazole and oral vancomycin. The patient subsequently developed a surgical abdomen secondary to refractory C. difficile colitis, but was successfully treated with a combination of rifaximin and tigecycline after she refused to undergo surgical treatment. © 2012 Informa Healthcare.Berman AL, 2007, J CLIN GASTROENTEROL, V41, P932; Cheong EYL, 2011, MED J AUSTRALIA, V194, P374; Cohen SH, 2010, INFECT CONT HOSP EP, V31, P431, DOI 10.1086-651706; Hawser SP, 2010, INT J ANTIMICROB AG, V35, P97, DOI 10.1016-j.ijantimicag.2009.09.009; Herpers BL, 2009, CLIN INFECT DIS, V48, P1732, DOI 10.1086-599224; Johnson S, 2009, ANAEROBE, V15, P290, DOI 10.1016-j.anaerobe.2009.08.004; Johnson S, 2007, CLIN INFECT DIS, V44, P846, DOI 10.1086-511870; Jump RLP, 2011, ANTIMICROB AGENTS CH, V55, P546, DOI 10.1128-AAC.00839-10; Kopterides P, 2010, ANAESTH INTENS CARE, V38, P755; Lu CL, 2010, INT J ANTIMICROB AG, V35, P311, DOI 10.1016-j.ijantimicag.2009.11.008; Neff G, 2010, LIVER TRANSPLANT, V16, P960, DOI 10.1002-lt.22092; Nord CE, 2006, ANTIMICROB AGENTS CH, V50, P3375, DOI 10.1128-AAC.00373-06; Noren T, 2010, CLIN MICROBIOL INFEC, V16, P1104, DOI 10.1111-j.1469-0691.2009.03048.x; Wilcox MH, 2007, CLIN MICROBIOL INFEC, V13, P949, DOI 10.1111-j.1469-0691.2007.01792.x66
Analysis of Heavy Metal Ions in Potable Water Using Soft Computing Technique
No full textAbstractThe water quality analysis has been an intriguing subject in the recent years because of the issues related to water resources. The work presents the application of the genetic algorithm to water samples containing contaminants for the optimal selection of electrode and the corresponding frequency for the better classification of various contaminants. We have used 24 water samples containing 8 different heavy metal ions (Cd, Co, Zn, Ni, Cu, Cr, Ar and Pb) for our experiment. The electrodes used were Gold, Platinum, Glassy Carbon and Silver Nanoparticle electrode. The impedance values of these four electrodes are recorded as Single-Electrode Multi-Frequency (SEMF), Single-Frequency Multi-Electrode (SFME) and Multi-Electrode Multi-Frequency (MEMF). The impedance values are subjected to Principal Component Analysis. Further, the optimal classification of various metal ions present in the water samples is done using Genetic Algorithm and this is validated by the application of Davis Bouldin index. The results show that DBI value may be enhanced by choosing electrode with optimum frequency
