4,405 research outputs found
Recommended from our members
Exploring automatic grouping procedures in ceramic petrology
No full textMathematics, statistics and archaeometry: the past 50 years or so
No full textThis review of developments in the use of mathematics and statistics in archaeometry over the past 50 years is partial, personal and 'broad-brush'. The view is expressed that it is in the past 30 years or so that the major developments have taken place. The view is also expressed that, with the exception of methods for analysing radiocarbon dates and increased computational power, mathematical and statistical methods that are currently used, and found to be useful in widespread areas of application such as provenance studies, don't differ fundamentally from what was being done 30 years ago
Recommended from our members
An R library for compositional data analysis in archaeometry
No full text
Recommended from our members
Notes on some statistical aspects of pottery quantification
No full textThe quantification of finds assemblages from excavations, as an aid to the comparative study of assemblages and sites, is a developing and increasingly important aspect of post-excavation analysis. In the area of pottery studies a major influence has been the work of Clive Orton and Paul Tyers, culminating in the recent release of the 'pie-slice' package for computer analysis. Much of the published literature is either highly technical, or of an expository nature which needs a great deal of the technical material and underlying assumptions to be taken on trust. The present paper is intended to be intermediate between these two levels. We address some of the more complex or less obvious issues involved in application of the pie-slice 'philosophy'. A worked example is given to highlight aspects of some of the assumptions and calculations involved. Some attention is given to what can be done outside the pie-slice package. One concern is the analysis of assemblages that have been quantified using estimated vessel equivalents (eves), but not in a manner that allows conversion to pottery information equivalents (pies) in the pie-slice package
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor
No full textSelective therapeutics for nuclear receptors would revolutionize treatment for endocrine disease. Specific control of nuclear receptor activity is challenging because the internal cavities that bind hormones can be virtually identical. Only one highly selective hormone analog is known for the thyroid receptor, GC-24, an agonist for human thyroid hormone receptor beta. The compound differs from natural hormone in benzyl, substituting for an iodine atom in the 3' position. The benzyl is too large to fit into the enclosed pocket of the receptor. The crystal structure of human thyroid hormone receptor beta at 2.8-A resolution with GC-24 bound explains its agonist activity and unique isoform specificity. The benzyl of GC-24 is accommodated through shifts of 3-4 A in two helices. These helices are required for binding hormone and positioning the critical helix 12 at the C terminus. Despite these changes, the complex associates with coactivator as tightly as human thyroid hormone receptor bound to thyroid hormone and is fully active. Our data suggest that increased specificity of ligand recognition derives from creating a new hydrophobic cluster with ligand and protein components
Recommended from our members
Notes on the statistical analysis of some loomweights from Pompeii
No full textRecent work, in the field, on the dimensions and weights of loomweights from excavations in Insula VI.I, Pompeii suggested – to our surprise – that there was structure in the form of evidence of bi-modality in the weights. The paper has two purposes. One is to illustrate a variety of statistical methods that were used to confirm the validity of our observations. The other is to discuss what the archaeological implications of this might be. A more general point is that if more attention is given to what are often regarded as “uninteresting” artefacts some interesting results may emerge - specifically, it can be asked whether loomweights have chronological significance for interpreting archaeological sites (at Pompeii at least)
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
- …
