289 research outputs found
Moving together: the organisation of non-verbal cues during multiparty conversation
No full textPhDConversation is a collaborative activity. In face-to-face interactions interlocutors have mutual
access to a shared space. This thesis aims to explore the shared space as a resource for coordinating
conversation. As well demonstrated in studies of two-person conversations, interlocutors
can coordinate their speech and non-verbal behaviour in ways that manage the unfolding conversation.
However, when scaling up from two people to three people interacting, the coordination
challenges that the interlocutors face increase. In particular speakers must manage multiple listeners.
This thesis examines the use of interlocutors’ bodies in shared space to coordinate their
multiparty dialogue.
The approach exploits corpora of motion captured triadic interactions. The thesis first explores
how interlocutors coordinate their speech and non-verbal behaviour. Inter-person relationships
are examined and compared with artificially created triples who did not interact. Results demonstrate
that interlocutors avoid speaking and gesturing over each other, but tend to nod together.
Evidence is presented that the two recipients of an utterance have different patterns of head and
hand movement, and that some of the regularities of movement are correlated with the task structure.
The empirical section concludes by uncovering a class of coordination events, termed simultaneous
engagement events, that are unique to multiparty dialogue. They are constructed using
combinations of speaker head orientation and gesture orientation. The events coordinate multiple
recipients of the dialogue and potentially arise as a result of the greater coordination challenges
that interlocutors face. They are marked in requiring a mutually accessible shared space in order
to be considered an effective interactional cue.
The thesis provides quantitative evidence that interlocutors’ head and hand movements are
organised by their dialogue state and the task responsibilities that the bear. It is argued that a
shared interaction space becomes a more important interactional resource when conversations
scale up to three people
On liberty and crime: Adam Smith and John Stuart Mill
No full textThe author considers some of the works produced by Adam Smith and John Stuart Mill, who from different perspectives discuss notions such as transgression, deviance and crime. It is argued that the analysis of power crime may immensely benefit from an excavation into economics, for its concern about the creation and acquisition of wealth, the legitimacy of certain conducts as opposed to others, and ultimately the circumstances in which competition and enterprise may cause human and social harm
On liberty and crime: Adam Smith and John Stuart Mill
No full textThe author considers some of the works produced by Adam Smith and John Stuart Mill, who from different perspectives discuss notions such as transgression, deviance and crime. It is argued that the analysis of power crime may immensely benefit from an excavation into economics, for its concern about the creation and acquisition of wealth, the legitimacy of certain conducts as opposed to others, and ultimately the circumstances in which competition and enterprise may cause human and social harm
John Stuart Mill’s projected science of society: 1827-1848
No full textThe purpose of the thesis is to examine John Stuart Mill’s political thought from
about 1827 to 1848 as an exercise in intellectual history. It focuses, first, on Mill’s view,
formulated by the late 1830s, that contemporary society was ‘civilized’, and second, on
his project of a science of society, which he aspired to develop in the late 1830s and
early 1840s.
By the late 1830s, Mill came to the view that his contemporary society was a
‘commercial society or civilization’, dominated by the middle, commercial class. The
first part of my thesis, constituted by Chapters 2-4, discusses the way in which Mill
formed his notion of civilization, and what he meant by the term ‘civilization’. Mill paid
attention to the implications of the rise of the middle class, and regarded such
phenomena of contemporary society as the corruption of the commercial spirit and
excessive social conformity as an inevitable consequence of the rise of the middle class.
The second part of the thesis, constituted by Chapters 5-9, examines Mill’s
projected science of society. In the late 1830s and early 1840s, Mill attempted to
develop a new science of society whose subject-matter was the nature and prospects of
commercial, civilized society. This aspiration culminated in A System of Logic,
published in 1843. In examining Mill’s projected science, I pay particular attention to
the fact that he conceived new sciences of history and of the formation of character,
both of which were indispensable in his project, although he failed to give a complete
account of these sciences. My thesis shows that the implications of his interest both in
history and in the formation of character are more significant than Mill scholars have
assumed
Redemption in the work of Francis Stuart
No full textThe idea of redemption is central to an understanding of the work
of Francis Stuart. Through an examination of its development and
expression, it is possible to demonstrate the integrity of his work and
its distinctive qualities. Such a demonstration is necessary because
Stuart's writing has been subjected to comparatively little scholarly
inquiry, although reviews of his work, especially that produced since
1949, suggest that it is impressive and important.
First, a general background to Stuart's work, a discussion of the
special problems associated with reading it, and a summary of his corpus
is provided. This indicates that the idea of redemption is important to
his earliest writing. The state of redemption is shown to be a
necessary apotheosis for Stuart's outcast heroes; it involves spiritual
suffering through which may be found a sense of reintegration and a
higher reality. This is expressed through interrelated themes such as
those of gambler, artist and ordinary man; mystic and criminal; sacred
and profane love; and spirituality and the mundane. The nature of the
redemptive experience is further elaborated by distinctive, complex
motifs, especially the hare, the ark and the woman-Christ. Their
recurrence provides an important element in the unity of Stuart's work.
Because Stuart's idea of the outcast raises important biographical
questions, an examination of the relationship between Stuart's life and
his work is made. Finally, the way in which the idea of redemption
exists in the language structures of Stuart's novels is examined, with
especial reference to his most recent work, The High Consistory. The
thesis shows that the development of the these of redemption
demonstrates the integrity of Stuart's work
Esej o aktualność teorii Stuarta Halla w kontekście badań nad blogosferą
No full textThis essay is talking about topicality of Stuart Hall theory. Author of essay is contending that the Coding/encoding theory of Stuart Hall is still useful in works on blogosphere.In essay author explained the Coding/encoding theory and notions of blogosphere. The author is arguing that that using Coding/encoding theory in works about blogosphere. The author is pointing prospective tesis up
Beauty for the Present: Mill, Arnold, Ruskin and Aesthetic Education
No full textThe present thesis examines the idea of aesthetic education of three eminent Victorians: John Stuart Mill, Matthew Arnold and John Ruskin. By focusing on the essence of what they meant with ‘the cultivation of the beautiful’ and, more importantly, the way their ideas of beauty informed their criticism of society, my study aims to contribute to our understanding of the idea of aesthetic education in the Victorian context and, further, to participate in a recent debate about the nature of beauty and aesthetic education.
Chapter One focuses on John Stuart Mill’s concept of ‘feeling’ in a series of essays. I will demonstrate how Mill’s idea of ‘aesthetic education’ was an ‘education of feelings,’ and moreover, how this idea was integrated into his literary criticism, his later critique of democratisation, his description of an ideal liberal society and even his own style of writing. Chapter Two contains a comparative study of Matthew Arnold and Friedrich Schiller. Through a rereading of Arnold, I will argue that his idea of aesthetic education is essentially Schillerian and that their resemblance consists primarily in their stress on the importance of aesthetic unity for modern life, which was becoming increasingly fragmentary and multitudinous. Chapter Three examines John Ruskin’s idea of aesthetic education and concentrates particularly on the cultivation of perception. Perception, as I shall show, was pivotal in Ruskin’s idea of aesthetic education. Just as what happened in Mill and Arnold, the emphasis on the education of seeing continued from his early writings well into his art and social criticisms. It not only differentiated him from his fellow art critics; the conviction that people should perceive with a pure heart also enabled him to link observation of artistic details with moral criticism of contemporary society and, thereby, to turn the cultivation of the beautiful into a moral-aesthetic experience
Association of interleukin-6 signalling with the muscle stem cell response following muscle-lengthening contractions in humans
No full textBackgroundThe regulation of muscle stem cells in humans in response to muscle injury remains largely undefined. Recently, interleukin-6 (IL-6) has been implicated in muscle stem cell (satellite cell)-mediated muscle hypertrophy in animals; however, the role of IL-6 in the satellite cell (SC) response following muscle-lengthening contractions in humans has not been studied.Methodology/principal findingsEight subjects (age 22+/-1 y; 79+/-8 kg) performed 300 maximal unilateral lengthening contractions (3.14 rad.s(-1)) of the knee extensors. Blood and muscle samples were collected before and at 4, 24, 72, and 120 hours post intervention. IL-6, IL-6 receptor, IL-6R(alpha), cyclin D1, suppressor of cytokine signling-3 (SOCS3) mRNA were measured using quantitative RT-PCR and serum IL-6 protein was measured using an ELISA kit. JAK2 and STAT3 phosphorylated and total protein was measured using western blotting techniques. Immunohistochemical analysis of muscle cross-sections was performed for the quantification of SCs (Pax7(+) cells) as well as the expression of phosphorylated STAT3, IL-6, IL-6R(alpha), and PCNA across all time-points. The SC response, as defined by an amplification of Pax7(+) cells, was rapid, increasing by 24 h and peaking 72 h following the intervention. Muscle IL-6 mRNA increased following the intervention, which correlated strongly (R(2) = 0.89, pConclusions/significanceThe increased expression of STAT3 responsive genes and expression of IL-6 within SCs demonstrate that IL-6/STAT3 signaling occurred in SCs, correlating with an increase in SC proliferation, evidenced by increased Pax7(+)/PCNA(+) cell number in the early stages of the time-course. Collectively, these data illustrate that IL-6 is an important signaling molecule associated with the SC response to acute muscle-lengthening contractions in humans
The Beautiful Art of Losing: Queer Theories and Failure
No full textThe author presents a survey of the mode of functioning of the category of failure in the context of phenomena describes as the anti-social turn in queer theory. In the focus of analysis there are, among others, works by Leo Bersani, Lee Edelman, José Esteban Muňoz. The article is mainly devoted to the ideas presented in Judith Halberstam’s "The Queer Art of Failure" (2011), a study that critically revises the relation connecting queerness with the concepts of negativity, shadow feminism, and designs a new perspective for queer research in popular culture, referring to Stuart Hall’s concept of low theory, and to Antonio Gramsci’s culture analysis.21215227Poznańskie Studia Polonistyczne. Seria Literack
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
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