263,231 research outputs found
batten out
No full textbatten v....make your fore hook,an' your midship bend an' after hook,an' put up your counter,your transom; an' you'd you'd batten her out then,an' frame her out; frame her out - get a_ have a leaden mould.YesDNE-citJ. D. A. WIDDOWSON JUL 1973Used IUsed IUsed ISource appears in DNE I as: T 183-6
batten
No full textbatten n_NID_: What a variety of senses in U. S. ! _G_: is _NID_ 5 a the Nfld sense enclosed? Should we exclude? OED v2[superscript] Cartwright - sb 1[superscript] 2 a ledge - Devine - but I'm not positive sb 3 "fixed over the hatchways" sb1[superscript] 2 A bar or strip (orig. as in sense 1) nailed or glued across a door or anything composed of parallel boards, to hold these together, give strength, or prevent warpingWithdrawNot usedUsed IWithdrawn'batten v' appears in the DNE I but NID sense 5 appears in reference to a nominal variant. Check mark by 'exclude', 'Cartwright' and 'Devine'. Card has been re-filed alphabetically in its drawer so it appears next to B_10563 'batten
Development of batten receptacle for sailingboats between 45 and 60 feet
No full textProjektet har utförts av designingenjörsstudenterna Magnus Arehorn och Niklas Ekholm under vårterminen 2016 i kursen Examensarbete inom integrerad produktutveckling på Högskolan i Skövde. Projektet har genomförts för Seldén Mast AB i Långedrag, Göteborg, som utvecklar däcks- och riggsutrustning för segelbåtar.Seldén har lattbeslag för segelbåtar upp till 45 fot, men vill utöka sitt sortiment till marknad för större segelbåtar. De befintliga lattbeslagen skulle då inte vara tillräckligt robusta varför ett nytt beslag krävs med starkare konstruktion. Målet var att utveckla ett lattbeslag för segelbåtar mellan 45 och 60 fot. Syftet med lattbeslaget är att spänna upp lattor i storseglet och utfå bättre vindupptagning.Utvecklingsområden undersöktes genom att delfunktioner för beslaget identifierades. En förstudie inleddes för att forska i utvecklingsmöjligheter inom områdena genom att se till befintliga lösningar via konkurrensanalys och behov i intervjuer med segelmakare och seglare. Beslaget förväntades vara billigt, robust, funktionellt samt unikt. Slutsatsen drogs att unika lösningar behövde finnas till en låg tillverkningskostnad.En idégenerering inleddes för att finna koncept med nytänkande och beprövade lösningar till låga kostnader. Två potentiella koncept togs fram som efter detaljutveckling viktades för att stå med ett slutligt resultat. Resultatet bedömdes vara ovanligt på marknaden och uppskattades ha en relativt låg tillverkningskostnad.This project has been carried out by the product design engineering students Magnus Arehorn and Niklas Ekholm during the spring of 2016, for the Bachelor Degree Project in Integrated Product Development at the University of Skövde. The project has been in cooperation with Selden Mast AB in Långedrag, Gothenburg, which develops rigging systems and deck hardware for sailboats.Seldén has batten receptacles for sailboats up to 45 feet, but wants to expand their range of products to the market for larger sailboats. The existing batten receptacle is not strong enough for that application which is why a new batten receptacle requires a stronger construction. The goal was to develop a batten receptacle for sailboats between 45 and 60 feet. The purpose of the batten receptacle is to increase the batten’s tension in the mainsail and form the sail more aerodynamic.Opportunities for development were explored by identifying sub functions of the batten receptacle. A pre-study was conducted to research the development opportunities in the areas by ensuring existing solutions through a competitive analysis and by identifying sailmakers’ and sailors’ needs through interviews. The batten receptacle was expected to be of low cost, robust, functional and unique. It was concluded that unique solutions had to be found at a low manufacturing cost.An idea generation was implemented to find concepts with innovative and proven solutions at low costs. Two potential concepts were developed and weighted with the goal to come to one final result. The result was considered to be rare on the market and estimated to have a relatively low manufacturing cost
Rapid diagnostic test for the major mutation underlying Batten disease
No full textBatten disease is the most common progressive neurodegenerative disorder of childhood in western countries. A novel cDNA responsible for Batten disease has recently been identified. We have developed a rapid diagnostic solid phase minisequencing test to detect the major 1.02 kb deletion which is responsible for 81% of affected chromosomes in Batten disease worldwide. In Finland, 90% of Batten chromosomes carry the major deletion owing to the enrichment of the CLN3 gene in the isolated Finnish population.</p
Dovetailed ledge and batten door
No full textUppsats för avläggande av filosofie kandidatexamen i kulturvård, bygghantverk, 22,5 hp, 2017The purpose of this thesis has been to illuminate technical aspects associated with post-medieval dovetailed ledge and batten doors, i.e. dragspondører, in Norway. In order to answer questions regarding construction, design and material use, the method of investigation has been based on literature studies, field studies and practical craft experiments.
Literature studies have provided basic knowledge of the subject, whereas field studies have further broadened the knowledge through observations of actual doors. 30 ledge and batten doors from 11 different locations in Norway have been documented. The complete documentation forms the basic source material for this survey. In the practical craft experiment, wherein a copy of a 18th century dovetailed ledge and batten door was made, further practical aspects on construction, design and materials use has been highlighted.
Acquired knowledge from literature and field studies, as well as craft experiments, has led to a result that to a greater extent, highlights the technical aspects of dovetailed ledge and batten doors from the post-medieval period in Norway
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
No full textMutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to synaptic alterations, we investigated synaptic ultrastructure and function in presymptomatic CTSD knockout (Ctsd) mice. Electron microscopy revealed that there were significantly greater numbers of readily releasable synaptic vesicles present in Ctsd mice than in wild-type control mice as early as postnatal day 16. The size of this synaptic vesicle pool continued to increase with disease progression in the hippocampus and thalamus of the Ctsd mice. Electrophysiology revealed a markedly decreased frequency of miniature excitatory postsynaptic currents (mEPSCs) with no effect on paired-pulse modulation of the evoked excitatory post synaptic potentials in the hippocampus of Ctsd mice. The reduced mEPSCs frequency was observed before the appearance of epilepsy or any morphologic sign of synaptic degeneration. Taken together, these data indicate that CTSD is required for normal synaptic function and that a failure in synaptic trafficking or recycling may bean early and important pathologic mechanism in Ctsd mice; these presynaptic abnormalities may initiate synaptic degeneration in advance of subsequent neuronal loss
Prop loads in two large braced excavations
No full textThis thesis is concerned with temporary props used to support stiff reinforced concrete retaining walls cast in situ. Temporary props are usually designed using loads determined from some idealized method of analysis. There is however a widely-held view within the construction industry that current procedures tend to overestimate the actual prop loads, resulting in uneconomical designs. The aim of the research was to investigate the reasons for this apparent discrepancy by monitoring and analysis of the temporary prop loads developed during the construction of the London Underground Limited Jubilee Line extension stations at Canada Water and Canary Wharf. As well as prop loads, which were measured using vibrating wire strain gauges, prop temperatures were monitored in order to assess their influence on the prop loads. The research has shown that(i) Vibrating wire strain gauges can accurately and reliably monitor the loads developed in temporary steel props, providing certain basic guidelines are followed.(ii) Temporary-induced loads, which may account for a significant proportion of the total load, depend on the magnitude of the temperature rise and the degree of restraint provided to the ends of the prop by the structure and the retained soil. The effectiveness of the end restraint will probably be about 50% for high-level props but for low-level props may be as high as 65%. However, the range of temperature experienced by the props is likely to reduce with the depth of the excavation.(iii) Bending moments generated in the props as a result of temperature gradients and rotation of the wall will probably be of the same order as those due to the self-weight effects.(iv) Neglecting temperature effects, prop loads close to those measured can be calculated using modified limit equilibrium and finite element analyses, provided appropriate soil parameters and input conditions are assumed.</p
Wiley College and the Literacy Project
No full textIn the years after the Civil War until the 1930s, blacks in America undertook a literacy project -- a vast effort, long-lived, undertaken not by the power, authority, or bureaucracy of government, but instead by blacks acting on their own, unaware of similar efforts in a thousand other places. In the project, Wiley College in Marshall, Texas, a Historically Black College, assumed the obligation to develop leaders, equip teachers, and contribute in any way possible to Negro literacy. Scholars of black colleges have lumped all black colleges together and assumed that what was true about one college was true of all. While this paper does not argue that Wiley College is a representative case study, its story is so different from widely accepted narratives about black colleges that the paper supports the need for historians to take a fresh look at accepted narratives. Commonly held narratives state that the two crucial elements of Negro college success were overall direction by northern church denominations in the 1800s and financial support from northern foundations in the early decades of the twentieth century; they deny agency to leaders and supporters of HBCs like Wiley College. The narrative I trace shows people of Wiley, its President, Matthew W. Dogan, and the blacks of East Texas in charge of the college and engaged in the literacy project.M.A.Includes bibliographical referencesby James C. Batte
Wind load fluctuations on roof batten to rafter/truss connections
No full textBatten to rafter connections in light framed housing can be vulnerable to progressive or cascading failures where a localised failure can cause the loss of a large section of the roof envelope. The synchrony of loads at neighbouring connections may affect the initiation of such failures. A 1/50 length scale wind tunnel model study was performed on a gable roof house to record spatial and temporal pressure fluctuations on the roof surface and data were studied to determine the flow separation mechanisms causing different loading patterns on batten to rafter connections. The cross correlation between load time histories was used to give a measure of synchrony between loads experienced at neighbouring connections and indicate the direction that fluctuations move across the roof. Orthogonal wind directions result in 2-dimensional flow separation that produce more synchronous loads at batten to rafter connections than cornering wind directions, where conical vortices produce high uplift forces on connections. The patterns of loading and their correlations give a means of identifying which parts of the roof and which approach wind directions may result in the initiation of a progressive failure of batten to rafter connections
Searching for novel biomarkers using a mouse model of <i>CLN3</i>-Batten disease
No full textCLN3-Batten disease is a rare, autosomal recessive disorder involving seizures, visual, motor and cognitive decline, and premature death. The Cln3Δex7/8 mouse model recapitulates several phenotypic characteristics of the most common 1.02kb disease-associated deletion. Identification of reproducible biomarker(s) to facilitate longitudinal monitoring of disease progression and provide readouts for therapeutic response has remained elusive. One factor that has complicated the identification of suitable biomarkers in this mouse model has been that variations in animal husbandry appear to significantly influence readouts. In the current study, we cross-compared a number of biological parameters in blood from Cln3Δex7/8 mice and control, non-disease mice on the same genetic background from multiple animal facilities in an attempt to better define a surrogate marker of CLN3-Batten disease. Interestingly, we found that significant differences between Batten and non-disease mice found at one site were generally not maintained across different facilities. Our results suggest that colony variation in the Cln3Δex7/8 mouse model of CLN3-Batten disease can influence potential biomarkers of the disease.</div
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