102,613 research outputs found
Dr M T Batchelor, Physics
No full textL to R: Dr B I Henry and Dr M T Batchelor, Physics awarded first prize from British Institute of Physics in 1990, Beauty of Physics exhibitio
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
A. T. Prior
No full text"A.T. (Tom) Prior 12 Squadron R.A.A.F. Darwin & Batchelor Dec 1941 - 1943."A.T. (Tom) Prior. 12 Squadron, Royal Australian Air Force. Darwin & Batchelor. December 1941 - 1943.Date:199
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
The quantum inverse scattering method with anyonic grading
No full textWe formulate the quantum inverse scattering method for the case of anyonic grading. This provides a general framework for constructing integrable models describing interacting hard-core anyons. Through this method we reconstruct the known integrable model of hard core anyons associated with the XXX model, and as a new application we construct the anyonic t − J model. The energy spectrum for each model is derived by means of a generalization of the algebraic Bethe ansatz. The grading parameters implementing the anyonic signature give rise to sector-dependent phase factors in the Bethe ansatz equations
Kraichnan-Leith-Batchelor similarity theory and two-dimensional inverse cascades
No full textWe study the scaling properties and Kraichnan-Leith-Batchelor (KLB) theory of forced inverse cascades in generalized two-dimensional (2D) fluids (-turbulence models) simulated at resolution . We consider (surface quasigeostrophic flow), (2D vorticity dynamics) and . The forcing scale is well-resolved, a direct cascade is present and there is no large-scale dissipation. Coherent vortices spanning a range of sizes, most larger than the forcing scale, are present for both and . The active scalar field for contains comparatively few and small vortices. The energy spectral slopes in the inverse cascade are steeper than the KLB prediction in all three systems. Since we stop the simulations well before the cascades have reached the domain scale, vortex formation and spectral steepening are not due to condensation effects; nor are they caused by large-scale dissipation, which is absent. One- and two-point pdfs, hyperflatness factors and structure functions indicate that the inverse cascades are intermittent and non-Gaussian over much of the inertial range for and , while the inverse cascade is much closer to Gaussian and non-intermittent. For the steep spectrum is close to that associated with enstrophy equipartition. Continuous wavelet analysis shows approximate KLB scaling () and () in the interstitial regions between the coherent vortices. Our results demonstrate that coherent vortex formation ( and ) and non-realizability () cause 2D inverse cascades to deviate from the KLB predictions, but that the flow between the vortices exhibits KLB scaling and non-intermittent statistics for and . The results will appear in \cite{BurgessEA2015}, which has been accepted to the \emph{Journal of Fluid Mechanics}
Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis
No full textPrecursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe the first highly- penetrant zebrafish pre-B ALL, driven by human MYC. Leukemias express B lymphoblast-specific genes and are distinct from T cell ALL (T-ALL)—which these fish also develop. Zebrafish pre-B ALL shares in vivo features and expression profiles with human pre-B ALL, and these profiles differ from zebrafish T-ALL or normal B and T cells. These animals also exhibit aberrant lymphocyte development. As the only robust zebrafish pre-B ALL model and only example where T-ALL also develops, this model can reveal differences between MYC-driven pre-B vs. T-ALL and be exploited to discover novel pre-B ALL therapies
Letter from Stephen T. Mather to Carl Hayden
No full textLetter from Stephen T. Mather to Carl T. Hayden thanking Hayden for his advice about visiting Arizon
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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