1,721,295 research outputs found
High loading beads for single bead screening in combinational chemistry
No full textCombinatorial chemistry and solid-phase synthesis have revolutionised the process of drug discovery in the last decade. Ever since the concept of split and mix synthesis was introduced in 1988, and in particular the concept of one bead one compound. this approach has been associated with the possibility of generating thousands or millions of compounds in only a relatively small number of synthetic steps. With the miniaturisation of screening assays the amount of compound released by a single resin bead has become sufficient for biological test. However, if multiple screenings, IC50 determination or direct structure characterisation are required, commercially available resins are not suitable. Therefore the demand for high-loading resins has drastically increased over the last years.The research reported here is focussed on bead-loading enhancement, via a dendrimerisation process. Two different types of high loading dendrimer resins have been synthesised.Polyamidoamine (PAMAM) dendrimer resin has been used for the solid phase synthesis of various classes of compounds, involving many different chemical conditions. Robustness, swelling properties and suitability for single bead screening have also been investigated.Polyether dendrimer resin has been synthesised for the first time and again chemical inertness and mechanical properties have been explored.Both dendrimer resins can be conveniently and efficiency synthesised starting from commercially available resins, they are inert under severe chemical conditions and the final loading is sufficient for multiple single bead screenings.</p
TOWARD GREEN ATOM ECONOMY: THE CONVENIENT MARRIAGE BETWEEN MULTICOMPONENT REACTIONS AND FLOW PHOTOCHEMISTRY
No full textBetween the two shores: Rosario's imaginaries around the Paraná Delta (19th, 20th and 21st centuries)
No full textFil: Ponzini, Bibiana. Universidad Nacional de Rosario; ArgentinaFil: Galimberti, Cecilia Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Nacional de Rosario; ArgentinaFil: Basso, Andrea. Universidad Nacional de Rosario; Argentin
Results of a Peer Review Activity in an Organic Chemistry Laboratory Course for Undergraduates
No full textThis paper presents preliminary results of the incorporation
of the peer review process into the laboratory component of an organic
chemistry course for second year undergraduate students in the biological
sciences in Italy. The study was conducted on a class of 64 students and
incorporated a training session, a double-blind peer revision of laboratory
reports, and a final debriefing phase with evaluation of the activity both by
the instructor and by the students. Improvement of students’ writing skills
was monitored together with their ability to provide a feedback review and
to critically analyze the feedback comments received. The results indicate
that the participants made moderate improvements in their ability to write
a laboratory report and were able to evaluate the quality of their peers’
writing but also struggled with various aspects of the peer review process
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