1,720,967 research outputs found
Identificació dels mecanismes que regeixen la progressió de la malaltia hepàtica avançada per fetge gras no alcohòlic
Full text link[cat] La cirrosi per fetge gras no alcohòlic (FGNA) associada a la síndrome metabòlica és una entitat de prevalença creixent la història natural i factors pronòstics de la qual són poc coneguts. De fet, l'evidència existent apunta que podria comportar-se de manera diferent que la resta de causes de cirrosi més estudiades com l'alcohòlica o la viral. La hipòtesi d'aquesta tesi és que tant la història natural com els factors pronòstics, entre ells, el gradient de pressió venós portal (GPVP) podrien comportar-se de manera diferent en aquesta entitat respecte al que ja es coneix en les altres causes de cirrosi. Els objectius són analitzar la incidència de descompensació i desenvolupament de càncer, així com els factors de risc de descompensació en una cohort de pacients amb cirrosi per FGNA. A més, un altre objectiu és caracteritzar hemodinàmicament aquests pacients comparant-los amb una cohort amb cirrosi de causa viral.
En el primer estudi que conforma aquesta tesi hem analitzat de forma retrospectiva una cohort de 449 pacients diagnosticats de cirrosi compensada per FGNA entre 2009 i 2018. Hem trobat que la incidència de descompensació i desenvolupament de càncer són més elevades del que estava prèviament descrit. Els factors de risc de descompensació són fonamentalment de tipus hepàtic, però hem trobat que la cardiopatia isquèmica al diagnòstic és un factor pronòstic important cosa que no s’havia descrit fins ara. Al segon estudi hem comparat un grup de pacients amb cirrosi per FGNA i un altre amb cirrosi per virus C. La troballa fonamental és que els pacients amb cirrosi per FGNA es descompensen a valors inferiors de GPVP comparats amb el grup de cirrosi per virus C.
En conclusió, la cirrosi per FGNA presenta una alta incidència de descompensació i càncer i els factors de risc associats a la descompensació són fonamentalment hepàtics. El GPVP podria no estimar el risc de descompensació de manera adequada en els pacients amb cirrosi per FGNA.[eng] Cirrhosis due to non-alcoholic fatty liver disease (NAFLD) is an entity of increasing prevalence whose natural history and prognostic factors are poorly understood. In fact, the existing evidence suggests that it could behave differently than the other more studied causes of cirrhosis such as alcoholic or viral. The hypothesis of this thesis is that both the natural history and the prognostic factors such as the hepatic venous pressure gradient (HVPG) could behave differently in this entity compared to what is already known in the other causes of cirrhosis. The objectives are to analyze the incidence of decompensation and cancer development, as well as risk factors for decompensation in a cohort of patients with cirrhosis due to NAFLD. Another objective is to hemodynamically characterize these patients by comparing them with a cohort with cirrhosis of viral cause.
In the first study that makes up this thesis, we retrospectively analyzed a cohort of 449 patients diagnosed with compensated cirrhosis due to NAFLD between 2009 and 2018. We found that the incidence of decompensation and cancer development were higher than previously described. The risk factors for decompensation were mainly related to liver function, but we found that the presence of ischemic heart disease at diagnosis was an important prognostic factor, something that had not been described until now. In the second study, we compared a group of patients with NAFLD cirrhosis and another with cirrhosis due to hepatitis C virus (HCV). The key finding is that patients with FGNA cirrhosis decompensate at lower HVPG values compared to the group with cirrhosis due to HCV.
In conclusion, cirrhosis due to NAFLD has a high incidence of decompensation and cancer and the risk factors associated with decompensation are mainly hepatic. The HVPG may not estimate the risk of decompensation adequately in patients with NAFLD cirrhosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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