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Bill Basquin [catalog]
No full textThis document is a catalog of the artwork (films, installations, and sculptures) that I produced while a Visual Art MFA student at the University of California, San Diego
Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
No full textThe coronavirus disease 2019 (COVID-19) pandemic is fading, however its etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues posing - despite the availability of licensed vaccines - a global health threat, due to the potential emergence of vaccine-resistant SARS-CoV-2 variants. This makes the development of new drugs against COVID-19 a persistent urgency and sets as research priority the validation of novel therapeutic targets within the SARS-CoV-2 proteome. Among these, a promising one is the SARS-CoV-2 nucleocapsid (N) phosphoprotein, a major structural component of the virion with indispensable role in packaging the viral genome into a ribonucleoprotein (RNP) complex, which also contributes to SARS-CoV-2 innate immune evasion by inhibiting the host cell type-I interferon (IFN-I) response. By combining miniaturized differential scanning fluorimetry with microscale thermophoresis, we found that the 100-year-old drug Suramin interacts with SARS-CoV-2 N N-terminal domain (NTD) and C-terminal domain (CTD), thereby inhibiting their single-stranded RNA (ssRNA) binding function with low-micromolar Kd and IC50 values. Molecular docking suggests that Suramin interacts with basic NTD cleft and CTD dimer interface groove, highlighting three potentially druggable ssRNA binding sites. Electron microscopy shows that Suramin inhibits the formation in vitro of RNP complex-like condensates by SARS-CoV-2 N with a synthetic ssRNA. In a dose-dependent manner, Suramin also reduced SARS-CoV-2-induced cytopathic effect on Vero E6 and Calu-3 cells, partially reverting the SARS-CoV-2 N-inhibited IFN-I production in 293T cells. Our findings indicate that Suramin inhibits SARS-CoV-2 replication by hampering viral genome packaging, thereby representing a starting model for design of new COVID-19 antivirals
A. Basquin, O. S. B., Les peintres de Marie. Essai sur l'art martial
No full textSalaville Sévérien. A. Basquin, O. S. B., Les peintres de Marie. Essai sur l'art martial. In: Échos d'Orient, tome 20, n°121, 1921. pp. 123-124
Fatigue Life Assessment of API Steel Grade X65 Pipeline Using a Modified Basquin Parameter of the Magnetic Flux Leakage Signal
No full textThis paper presents a modified fatigue life model of the Basquin equation using the stress parameter of the magnetic flux leakage signal. Most pipeline steels experience cyclic loading during service and the influence of the load history makes assessing fatigue behaviour more difficult. The magnetic flux leakage signal’s response to a uniaxial cyclic test of API X65 steel was measured with eight levels of ultimate tensile stress loads. The influence of dH(y)/dx on fatigue failure was the main concern in this study, the aim being to represent localised stress parameters in the modified Basquin equation. Both fatigue lives, experimental and predicted from the modified Basquin equation, were validated through reliability analysis, producing a 60% value when approaching 1.8 × 105 cycles. The fatigue data from the experiment produced a higher mean-cycle-to-failure value than the prediction data, with slightly different values of 3.37 × 105 and 3.28 × 105. Additionally, the modified Basquin equation’s predicted and the experimental fatigue lives were found to have a high R2 correlation value of 0.9022. The Pearson correlation also showed a good relationship between the fatigue lives, with an r value of 0.9801. Finally, the modified Basquin equation based on dH(y)/dx signals provided an accurate and alternative method for durability assessment
A. Basquin, O. S. B., Les peintres de Marie. Essai sur l'art martial
No full textSalaville Sévérien. A. Basquin, O. S. B., Les peintres de Marie. Essai sur l'art martial. In: Échos d'Orient, tome 20, n°121, 1921. pp. 123-124
Nouveaux Sphinx de Madagascar (Lepidoptera, Sphingidae)
No full textNew hawkmoths from Madagascar (Lepidoptera, Sphingidae). The study of the collections of the Muséum national d’Histoire naturelle, in Paris, and the remarks made by Paul Griveaud in his article about Malgassoclanis delicatus (Jordan) in 1971 revealed that the form maculalis is actually a valid species but that this author had mingled with another species. The authors redescribe Malgassoclanis delicatus (Jordan) and describe M. maculalis n. sp. and M. rufus n. sp. from Madagascar.L’étude des collections du Muséum national d’Histoire naturelle, à Paris, et des remarques faites par Paul Griveaud dans son travail sur Malgassoclanis delicatus (Jordan) en 1971 ont révélé que la forme maculalis est en réalité une espèce valide mais que cet auteur y avait confondu une autre espèce. Les auteurs redécrivent donc
Malgassoclanis delicatus et décrivent M. maculalis n. sp. et M. rufus n. sp. de Madagascar.Pierre Jacques, Basquin Patrick. Nouveaux Sphinx de Madagascar (Lepidoptera, Sphingidae). In: Bulletin de la Société entomologique de France, volume 122 (4),2017. pp. 479-483
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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