159 research outputs found
Clovis MainStreet: Community Economic Assessment
No full textAn assessment of the Clovis, NM trade area, including the community of Clovis, Curry County, and the eastern New Mexico plains region. Local demographic, economic, and housing data are cited to illustrate the characteristics of the Clovis market. Using a location quotient analysis, the author examines the strengths and weaknesses of the Clovis economy. He describes the downtown MainStreet district, and then briefly discusses the opportunities and challenges for the community. Illustrated with tables, charts, and maps
Global transcription and translation through growth and the cell cycle
No full textFor a population of cells to continuously reproduce, they must undergo two distinct fundamental processes; they need to grow, thus increasing their volume and their biomass, and they need to undergo cell division cycles, thus replicating their genetic information and propagating it to two daughter cells. Growth is a continuous process whilst the cell cycle consists of discrete events that take place in an ordered manner. How the production of biomass is coordinated through growth and through the discrete events of the cell cycles is not fully understood. DNA, the template for all RNA molecules and ultimately proteins, is replicated once per cell cycle. How cell size, the amount of DNA, and cell cycle changes affect the global production of RNA molecules and proteins remains unclear. In this work I develop single-cell assays to measure the level of global transcription and translation in unperturbed populations of yeast cells whilst monitoring the cell cycle stage of each cell and precisely measuring its size. I show that global transcription scales with both size and the amount of DNA, thus supporting the idea that the level of transcription of a cell is the result of a dynamic equilibrium between the number of RNA polymerases associating and disassociating from DNA. In addition, global translation scales with size, but also increases at a discrete stage of the cell cycle in late S-phase or early G2. Finally, the global translation assay reveals an unexpected single-cell temporal variability in the metabolic pathway responsible for the uptake and incorporation into peptides of an exogenous amino acid, and that this variability is modulated by proteins involved in the cell cycle and in the TOR pathway.Open Acces
1924-04-18 (April 18, 1924): Correspondence From Clovis Bevilaqua to Manoel de Oliveira Lima
No full text1903-11-16 (November 16, 1903): Correspondence From Clovis Bevilaqua to Manoel de Oliveira Lima
No full text1904-01-10 (January 10, 1904): Correspondence From Clovis Bevilaqua to Manoel de Oliveira Lima
No full text1909-10-16 (October 16, 1909): Correspondence From Clovis Bevilaqua to Manoel de Oliveira Lima
No full text1916-08-31 (August 31, 1916): Correspondence From Clovis Bevilaqua to Manoel de Oliveira Lima
No full text1920-01-21 (January 21, 1920): Correspondence From Clovis Bevilaqua to Manoel de Oliveira Lima
No full text1919-05-15 (May 15, 1919): Correspondence From Clovis Bevilaqua to Manoel de Oliveira Lima
No full textMigration and population models of North America and the implications they hold for Clovis
No full textAuthor examines the routes of migration
to the lower 48 United States, the models for populating the continent, the
number and nature of the migrations, and their implications for Clovis culture
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