1,721,065 research outputs found
Construction and validation of a yeast model system for studying in vivo the susceptibility to nucleoside analogues of DNA polymerase gamma allelic variants.
No full textStudio nel sistema modello Saccharomyces cerevisiae di mutazioni patologiche nel gene POLG codificante la DNA polimerasi mitocondriale
No full textConstruction and characterization of centromeric, episomal and GFP-containing vectors for Saccharomyces cerevisiae prototrophic strains
No full textConstruction of a yeast model system for studying in vivo susceptibility to stavudine of Polg allelic variants
No full textConstruction and validation of a yeast model system for studying in vivo the susceptibility to stavudine of Polg allelic variants
No full textConstruction and validation of a yeast model system for studying in vivo the susceptibility to stavudine of DNA polymerase gamma allelic variants
No full textYeast equivalents of disease-associated human POLG mutations show deleterious cooperative effects.
No full text
A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability
No full textIn the Saccharomyces cerevisiae strains used for genome sequencing and functional analysis, the mitochondrial DNA replicase Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains
The power of yeast in modeling human mutations: mitochondrial aminoacyl tRNA synthetases and mitochondrial tRNA modifiers
No full text- …
