177,121 research outputs found
Sitaxsentan improves time to clinical worsening in patients with pulmonary arterial hypertension
No full text
Classification of Patients with Congenital Systemic-to-Pulmonary Shunts Associated with Pulmonary Hypertension: Current Status and Future Directions
No full textEisenmenger syndrome and pulmonary arterial hypertension in adults with congenital heart disease
No full textSitaxsentan, a selective endothelin-A receptor antagonist, improves exercise capacity in pulmonary arterial hypertension (PAH) associated with connective tissue disease (CTD)
No full textSTRIDE-2 Trial: a placebo-controlled study for sitaxsentan in pulmonary arterial hypertension
No full textAppropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Long-term outcome in pulmonary arterial hypertension patients treated with treprostinil.
No full textPulmonary arterial hypertension (PAH) is fatal if untreated. Intravenous
epoprostenol improves exercise capacity and hemodynamics in PAH, and increases
survival in idiopathic PAH (IPAH). To evaluate the effects of subcutaneous (SC)
treprostinil, a longer acting prostacyclin analogue, followed by the addition of
other PAH therapies if needed, we followed 860 PAH patients treated with SC
treprostinil for up to 4 years.Survival is reported as Kaplan-Meier estimates;
for 332 IPAH patients with baseline hemodynamics, observed survival is also
compared with predicted survival, using the NIH formula.Of the total 860
patients, 199 (23%) discontinued due to AEs, 136 (16%) died, 117 (14%)
discontinued due to deterioration, 29 (3%) withdrew consent and 11 (1%)
underwent transplantation. 97 patients (11%) switched from SC treprostinil to an
alternative prostacyclin analogue; bosentan was added in 105 patients (12%) and
sildenafil in 25 patients (3%).Survival was 87%-68% over 1-4 years for all 860
patients and 88%-70% over 1-4 years with SC treprostinil monotherapy. For the
IPAH subset with baseline hemodynamics (n=332), 91%-72% over 1-4 years; in
contrast, predicted survival was 69%-38% over 1-4 years. The safety profile for
long-term SC treprostinil was consistent with previous short-term trials with no
unexpected AEs
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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