210 research outputs found

    The development of English-language hymnody and its use in worship : 1960-1995.

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    SIGLEAvailable from British Library Document Supply Centre-DSC:DXN039276 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Landscape-painter as landscape-gardener : the case of Alfred Parsons R.A.

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    In 2 vols.Available from British Library Document Supply Centre-DSC:DXN016830 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

    Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus

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    AbstractObjective: This study was undertaken to investigate the role of the angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor in the development and progression of Barrett esophagus and adenocarcinomas of the esophagus and gastroesophageal junction. Methods: Vascular endothelial growth factor and basic fibroblast growth factor messenger RNA expression levels, relative to the control gene encoding β-actin, were measured by using a quantitative reverse transcription-polymerase chain reaction method (ABI 7700 Sequence Detector system) in specimens of Barrett intestinal metaplasia (n = 16), dysplasia (n = 11), adenocarcinoma (n = l 5), and matching normal squamous esophageal tissues (n = 35). Vascular endothelial growth factor and basic fibroblast growth factor protein expression and CD31+ microvessel density were assessed by means of immunohistochemistry in 25 tissue sections that included representative areas for each of these Barrett stages. Results: Expression levels were significantly increased in adenocarcinoma compared with in either normal squamous mucosa (P <.0001 for both genes) or intestinal metaplasia (vascular endothelial growth factor, P =.002; basic fibroblast growth factor, P <.0001). Vascular endothelial growth factor levels were also significantly higher in cancer tissues compared with dysplasia tissues (P =.024, Mann-Whitney U test). Basic fibroblast growth factor expression was also significantly increased in Barrett dysplastic mucosa compared with in intestinal metaplasia or normal esophageal mucosa. Microvessel density was generally higher in adenocarcinoma compared with in preneoplastic Barrett tissues. The pattern of vascular endothelial growth factor and basic fibroblast growth factor protein expression was similar to the messenger RNA expression pattern, with the exception that mucin-containing goblet cells stained intensely for vascular endothelial growth factor and only weak vascular endothelial growth factor staining was present in some adenocarcinomas. Conclusions: Vascular endothelial growth factor and basic fibroblast growth factor messenger RNA expression levels are significantly upregulated in esophageal and gastroesophageal junction adenocarcinomas, suggesting a role for these angiogenic factors in the development of these cancers. Vascular endothelial growth factor and basic fibroblast growth factor messenger RNA expression levels are also increased in some Barrett esophagus tissues, with this increase occurring at an earlier stage for basic fibroblast growth factor than for vascular endothelial growth factor. Basic fibroblast growth factor protein expression pattern is similar to the messenger RNA expression pattern, but unlike the messenger RNA findings, vascular endothelial growth factor protein expression is strongest in goblet cells.J Thorac Cardiovasc Surg 2003;125:246-5

    Dr. Reginald George Thomson (1934-2002)

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    RE: 4 ref.; SC: 0I; CA; VE; Z

    History and status of introduced ungulates on Rancho Piedra Blanca, California

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    Master of Science (MS)Natural Resources and EnvironmentUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/97702/1/39015003284448.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/97702/2/39015003284448.pd

    Contribution of Prof. H. W. E. Ntsan\u27wisi in the Development of the Mhala Area

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    This article is based on the presentation that the author made at a conference that was organised by the Oral History Association of South Africa (OHASA) and that was held in Mthatha, Eastern Cape on October 12, 2017. The theme of the conference was “Oliver Reginald Tambo in Memoriam: Reminiscing on a Centenary of Struggle.

    Some chemical problems in geology

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    This thesis is in the main a compilation of the views held at this institution in regard to the problems discussed as interpreted by the author. No claims for originality are made except in the manner of presentation as the material used has been obtained by conference and class room work with Professor V. H. Gottschalk and Professor G. H. Cox and also to some extent with H. A. Buehler, State Geologist. On the other hand the material is an expression of these ideas as assimilated by the author and hence may in certain cases differ radically from the views held by those mentioned above. It is hoped that this thesis may serve as an outline for future study of the subjects discussed and its main value is as such rather than as a contribution to the knowledge of chemical geology. With this in mind the bibliographies have been prepared with some care although they are by no means complete --Introduction, page [2]

    The Lateralis Group of the Bombylid Genus Villa

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    Author Institution: Department of Zoology and Entomolog
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