1,720,993 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
MicroRNA-based bioluminescent screening of a natural plant extracts library for cutaneous remodeling applications
No full textLes microARNs jouent un rôle essentiel dans la morphogénèse et l’homéostasie cutanée. Cette classe d’ARN non codant contrôle plusieurs voies de signalisation en régulant l’expression de réseaux entiers de gènes cibles. Ils sont donc considérés comme des cibles biologiques de choix pour les stratégies de criblage de composés bioactifs. Au laboratoire, nous avons conçu une sonde d’imagerie bioluminescente inductible par les microARNs, dénommée RILES pour « RNAi-Inducible Luciferase Expression System » qui se prête particulièrement bien au criblage cellulaire de librairies de composés synthétiques. Au cours de ce doctorat, nous avons placé le système RILES sous contrôle de l’axe de régulation TGF-β1/microARN-21 choisi pour son rôle central dans la ré-épithélialisation cutanée. Le criblage d’une extractothèque de 37 extraits bruts de plantes nous a permis d’identifier trois extraits bruts de plantes, dont celui du Chardon Marie (Silybum marianum (L.) Gaertn) qui a fait l’objet d’études mécanistiques et fonctionnelles poussées.Nous avons montré que l’effet de l’extrait de Chardon-Marie sur le microARN-21 est dépendant d'un complexe contenant six flavonolignanes, appelé silymarine (SM). Des études d’immunoprécipitation de la protéine Argonaute 2 couplée à laRT-qPCR ont permis de révéler un mécanisme de régulation original du microARN-21 par cet extrait. Le séquençage àhaut débit du transcriptome (RNA-seq) des kératinocytes en réponse au traitement par le TGF-β1 et la SM a permis demettre en évidence trois signatures d’expression génique majeures associées à la différenciation kératinocytaire, aucycle cellulaire et de façon inattendue au métabolisme des lipides. Nous avons montré que la SM bloque le cycle cellulaire en phase G0/G1, inhibe la différenciation des kératinocytes via l’inhibition de l’expression de Notch3 et active la synthèse des lipides en inhibant la phosphorylation d’AMPK et en augmentant l’activité transcriptionnelle de PPARγ. Parailleurs, la SM ralentit la migration cellulaire en perturbant la transition épithélio-mésenchymateuse et inhibe les réponses inflammatoires en bloquant l’activité transcriptionnelle de NF-ƙB. Du fait de ces propriétés biologiques, pour certaines nouvelles, nous avons évalué l’effet thérapeutique de la SM contre le développement du psoriasis en plaques induit par l’imiquimod chez la souris. Nos résultats indiquent que la SM pourrait représenter une alternative prometteuse « naturelle » aux traitements pharmacologiques actuels pour la prise en charge de cette pathologie.MicroRNAs play essential roles in skin morphogenesis and homeostasis. This class of non coding RNA mediates cross-talk between various signaling pathways through repression of multiple targeted genes. Therefore microRNAs areconsidered as relevant biological targets for screening of bioactive compounds. We previously developed a microRNAmonitoring system called RILES, standing for “RNAi-Inducible Luciferase Expression System” that was found particularlywell suited for cell-based screening of synthetic compound libraries. During this Ph.D project, we placed the RILESsystem under the control of the TGF-β1/microRNA-21 axis of regulation because of its pivotal role in the re-epithelialization process. Screening of 37 plant crude extracts enabled us to identify three plant extracts, for which themilk thistle (Silybum marianum (L.) Gaertn) extract was selected for further in-depth functional and mechanisticinvestigation. We showed that the activity of milk thistle extract on microRNA-21 expression is dependent on a mixture ofsix flavonolignans, called silymarin (SM). Argonaute 2 immunoprecipitation (RIP) coupled with RT-qPCR analysisunveiled an original mechanism of action of SM on microRNA-21 regulation. RNA next generation sequencing (RNA-seq)analysis of keratinocytes treated with TGF-β1 plus SM revealed three main transcriptomic signatures associated withkeratinocytes differentiation, cell cycle and surprisingly lipid metabolism. We showed that SM blocks cell cycleprogression in G0/G1 phase, inhibits keratinocytes differentiation through repression of Notch3 and stimulates lipidsynthesis via inhibition of AMPK phosphorylation and activation of PPARγ transcriptional activity. Besides, SM reduceskeratinocytes migration by interfering with epithelial-to-mesenchymal transition and inhibits inflammatory responses bysuppressing NF-ƙB transcriptional activity. Because of these novel biological properties, we evaluated the therapeuticefficacy of SM in IMQ-induced-psoriasis-like mouse model. Our results indicate that SM may represent a naturalalternative treatment for psoriasis management
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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