848 research outputs found
Proceedings of ASME Turbo Expo 2013: Power for Land, Sea and Air, Volume 1A: Combustion, Fuels and Emissions
No full textShahrokh Etemad (with Sandeep Alavandi and Benjamin Baird) is a contributing author, Fuel Flexible Rich Catalytic Lean Burn System for Low Btu Fuels
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
No full textBackground
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
Methods
Male rats were administered a dose range of ethanol (0, 0.5, 1, or 2 g/kg, intragastric) and brain tissue was removed 10 minutes later for evaluation of changes in p-cPKC expression using immunohistochemistry and Western blot methods.
Results
Immunohistochemical data show that the highest dose of ethanol (2 g/kg) rapidly increases p-cPKC immunoreactivity specifically in the nucleus accumbens (core and shell), lateral septum, and hippocampus (CA3 and dentate gyrus). Western blot analysis further showed that ethanol (2 g/kg) increased p-cPKC expression in the P2 membrane fraction of tissue from the nucleus accumbens and hippocampus. Although p-cPKC was expressed in numerous other brain regions, including the caudate nucleus, amygdala, and cortex, no changes were observed in response to acute ethanol. Total PKC? immunoreactivity was surveyed throughout the brain and showed no change following acute ethanol injection
Characterizing collagen mimetic peptides for orthogonal self-assembly
No full textA computational design of collagen mimetic peptides (CMPs) that self-assemble orthogonally (mutually exclusively), in the presence of other pre-existing collagen trimer mixtures, in vitro, has been proposed. The orthogonality in self-assembly was brought about by orthogonal patterning of ionic salt bridges and residues, along the collagen trimers’ axial length. Through the aid of circular dichroism spectroscopy alone, a novel experimental protocol was set-up to rapidly assess the level of cross-talk that may arise in such designed ‘heterogeneous monomer to trimer folding’ mixture environments. It is shown that the designed collagen mimetic peptides are stable and hetero-specific within their composite 3 chain peptide ecosystem. We experimentally demonstrate the extent to which loss in specificity could possibly occur, upon moving to a higher order ‘more than 3 monomers in solution’ peptide ensemble. Although the desired level of multi-state orthogonality was not achieved in the current design, the experimental results obtained were used to estimate the stability and specificity barrier threshold that one might run into, if one were to instead design orthogonal systems where-in specificity is incorporated during the computational design stage itself a priori. A Pareto frontier plot indicating the specificity versus stability trade-off is plotted. We conclude that a bottom-up design approach, incorporating design of specificity during the sequence design stage, would be a better way forward for achieving self-assembling orthogonality. In contrast to the complex chaperone assisted protein folding systems existing in nature, our method is a simplistic first step towards the complementary approach of modular synthetic collagen molecule design.Ph.D.Includes bibliographical referencesby Sandeep Vishwanath Belur
Resin and steel-reinforced resin used as injection materials in bolted connections
No full textInjection bolts are bolts in which the cavity produced by the clearance between the bolt and the wall of the hole is completely filled up with a two-component resin. Filling of the clearance is carried out through a small hole in the head of the bolt. After injection and complete curing, the connection is slip resistant. Recently the injection material, typically an epoxy resin, was modified at TU Delft by adding steel shots (spherical particles) to mitigate the effects of resin compliance in the shear connection of reusable composite (steel-concrete) structures. Experimental compressive material tests on unconfined/confined resin and steel-reinforced resin are evaluated in this chapter. The uniaxial model which combines damage mechanics and the Ramberg-Osgood relationship is proposed to describe the uniaxial compressive behavior of resin and steel-reinforced resin. First-order numerical homogenization is employed as a high-fidelity model, where a combined nonlinear isotropic/kinematic cyclic hardening model is employed to define the steel plasticity, the linear Drucker-Prager plastic criterion was used to simulate resin damage, and the cohesive surfaces reflecting the relationship between traction and displacement at the interface. The linear Drucker-Prager plastic model is used as a low-fidelity model.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Steel & Composite Structure
Anomaly-Based DNN Model for Intrusion Detection in IoT and Model Explanation: Explainable Artificial Intelligence
No full textIoT has gained immense popularity recently with advancements in technologies and big data. IoT network is dynamically increasing with the addition of devices, and the big data is generated within the network, making the network vulnerable to attacks. Thus, network security is essential, and an intrusion detection system is needed. In this paper, we proposed a deep learning-based model for detecting intrusions or attacks in IoT networks. We constructed a DNN model, applied a filter method for feature reduction, and tuned the model with different parameters. We also compared the performance of DNN with other machine learning techniques in terms of accuracy, and the proposed DNN model with weight decay of 0.0001 and dropout rate of 0.01 achieved an accuracy of 0.993, and the reduced loss on the NSL-KDD dataset having five classes. DL models are a black box and hard to understand, so we explained the model predictions using LIME.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
The role of local community in the repositioning process of Taranto as a sustainable tourist destination
No full textThe Apulian city of Taranto is known worldwide as a symbol of industrial pollution due to the presence of Europe’s largest steel plant. The plant is the subject of legal battles, and citizens protest because of its pollution and the consequent increase in numerous diseases. In recent years, local policymakers have been pursuing the city image repositioning through the reconversion of productive and entrepreneurial activities towards nature-based tourism development. The core of this strategy is the establishment of a Marine Protected Area, which the Environment Ministry is now examining. Subsequently, the City Council and Apulia Region will discuss their strategies, which seem to be converging to preserve fragile and valuable natural areas and give Taranto a new image as a sustainable tourist destination.
This is the beginning of an urban renovation towards a new image, in close continuity with an economic reconversion, to achieve the dual aim of protecting the environment and pursuing sustainable economic diversification. All revolves around the idea of developing sustainable tourism, rediscovering shellfish farming, and exploiting the sea, which is home to various protected species, particularly cetaceans.
However, this process must consider the multiple interests that need to be brought together, including the Military Navy, the fishing industry, other economic activities, and, above all, those of the local community. According to the literature, residents’ involvement is necessary to define effective governance models in most cases.
This chapter aims to focus on the role of the various stakeholders in the urban renovation and repositioning process. The qualitative research is carried out through in-depth interviews with different categories of stakeholders to investigate how the growth of social capital can foster the sustainable development of a destination through nature-based tourism
STUDIES ON PHYTOCHEMISTRY, ANTI-CANCER PROPERTIES OF BETULA UTILIS
No full textAbstract: Betula is a versatile plant with several applications. D. Don (family Betulaceae) is a long-lived tree that has been known in Sanskrit for about 400 years as Himalayan birch, bhojpatra, or Bhurja. Its usefulness as a therapeutic plant is well acknowledged. Birch bark has recently been the topic of scientific study and industry given the presence contains triterpenoids including such betulinic acid as well as oleanolic acid, that are well for their anticancer actions. A new anticancer medication, betulinic acid promotes apoptosis in the cancer cells. Therefore, It was unique from other cancer treatments. A number of B. utilis species have been reported to contain phenolics as well as flavonoids. Suitable investigations were carried out to assess phytochemicals qualitatively using various solvents, as well as anticancer activities utilising the SRB test.
Keywords: phytochemicals, anticancer medication, cancer cells.
Title: STUDIES ON PHYTOCHEMISTRY, ANTI-CANCER PROPERTIES OF BETULA UTILIS
Author: Sandeep Singh Bhau, Dr. Arti Chaurasia
International Journal of Interdisciplinary Research and Innovations
ISSN 2348-1218 (print), ISSN 2348-1226 (online)
Vol. 10, Issue 2, April 2022 - June 2022
Page No: 22-29
Research Publish Journals
Website: www.researchpublish.com
Published Date: 06-May-2022
DOI: https://doi.org/10.5281/zenodo.6524653
Paper Download Link (Source): https://www.researchpublish.com/papers/studies-on-phytochemistry-anti-cancer-properties-of-betula-utilisInternational Journal of Interdisciplinary Research and Innovations, ISSN 2348-1218 (print), ISSN 2348-1226 (online), Vol. 10, Issue 2, April 2022 - June 2022, Research Publish Journals, Website: www.researchpublish.co
Micromechanical Behavior of DNA‐1A Lunar Regolith Simulant in Comparison to Ottawa Sand
No full textIn this study, the micromechanical interparticle contact behavior of “De NoArtri” (DNA‐1A) grains is investigated, which is a lunar regolith simulant, using a custom‐built micromechanical loading apparatus, and the results on the DNA‐1A are compared with Ottawa sand which is a standard quartz soil. Material characterization is performed through several techniques. Based on microhardness intender and surface profiler analyses, it was found that the DNA‐1A grains had lower values of hardness and higher values of surface roughness compared to Ottawa sand grains. In normal contact micromechanical tests, the results showed that the DNA‐1A had softer behavior compared with Ottawa sand grains and that cumulative plastic displacements were observed for the DNA‐1A simulant during cyclic compression, whereas for Ottawa sand grains elastic displacements were dominant in the cyclic sequences. In tangential contact micromechanical tests, it was shown that the interparticle friction values of DNA‐1A were much greater than that of Ottawa sand grains, which was attributed to the softer contact response and greater roughness of the DNA‐1A grains. Widely used theoretical models both in normal and tangential directions were fitted to the experimental data to obtain representative parameters, which can be useful as input in numerical analyses which use the discrete element method
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Some exact solitons to the (2+1)-dimensional broer-kaup-kupershmidt system with two different methods
No full textThe author, Sandeep Malik, thankfully acknowledges CSIR SRF Grant: 09/1051(0028)/2018-EMR-I.
09/1051(0028)/2018-EMR-ICSIR SRF GrantThe exact solutions of the (2 + 1) dimensional Broer-Kaup-Kupershmidt (BKK) system which has been recommended to model the nonlinear and dispersive long gravity waves traveling along with the two horizontal directions in the shallow water of uniform depth were obtained. Firstly, the given system was reduced to an ordinary differential equation (ODE) with the help of the wave transformations. Then, the reduced ODE was solved with the help of two methods which are called the modified (G'/G)-expansion method and new extended generalized Kudryashov method. We checked the results with the Maple software and plotted 3D, contour and 2D plots of some obtained solutions. As a result, we obtained exact solutions that are different from each other and have not been obtained before. Results can enhance the nonlinear dynamical behavior of a given system and demonstrate the effectiveness of the employed methodology. Results will be beneficial to a large number of engineering model specialists and useful for understanding the wave motions
- …
