1,721,030 research outputs found
Prima della curva di Kuznets: stabilità e mutamento nella concentrazione di ricchezza e proprietà in età moderna
No full textIl saggio analizza le dinamiche di lungo periodo della disuguaglianza di ricchezza tra Medioevo ed Età Moderna: prima quindi della fase ascendente della nota "curva di Kuznets" (fase che sarebbe legata al processo di industrializzazione). L'articolo esamina sulla base dei dati dispobili per il caso Italiano l'ipotesi avanzata da Jan Van Zanden, secondo cui è possibile collegare la crescita della disuguaglianza "moderna" con quella "pre-moderna". Mentre fornisce supporto alla tesi di una crescita della disuguaglianza di lunghissimo periodo, il saggio contesta la tesi di Van Zanden, basata sul caso olandese, secondo cui ciò sarebbe da collegarsi alla crescita economica durante l'Età moderna. Il fatto che la disuguaglianza cresca anche in Italia, la cui economia attraversa una fase difficile a partire dal XVII secolo, suggerisce di cercare una diversa spiegazione del fenomeno
A proposito di «Enrichissement. Une critique de la marchandise» di Luc Boltanski e Arnaud Esquerre. II. I processi di «mise en valeur» delle collezioni barocche romane e le pratiche museali di ieri e di oggi
No full textLa collezione Giustiniani rappresenta uno di quei sistemi complessi della storia sociale dell’arte barocca.Questo sistema complesso e articolato, costituito dal luogo – palazzo Giustiniani inteso come una sorta di proto-museo, con collezioni in divenire – e dai suoi occupanti – il proprietario di casa e gli altri personaggi, ideatori e curatori del suo patrimonio artistico – crea un sistema di valorizzazione delle opere acquisite, attraverso la loro peculiare esposizione e attraverso una prima, sperimentale forma di catalogazione.Si possono ravvisare meccanismi non troppo dissimili, con le
dovute proporzioni di contesto, da quelli individuati nel libro recente di Luc Boltanski e Arnaud Esquerre, Enrichessement, che guarda essenzialmente alla Francia del XX e XXI secolo
Cushing's syndrome: Overview of clinical presentation, diagnostic tools and complications
No full textCushing's syndrome (CS) is a severe condition that results from chronic exposure to elevated circulating cortisol levels; it is a rare but potentially life-threating condition, especially when not timely diagnosed and treated. Even though the diagnosis can be straightforward in florid cases due to their typical phenotype, milder forms can be missed. Despite the availability of different screening tests, the diagnosis remains challenging as none of the available tools proved to be fully accurate. Due to the ubiquitous effect of cortisol, it is easy understandable that its excess leads to a variety of systemic complications including hypertension, metabolic syndrome, bone damages and neurocognitive impairment. This article discusses clinical presentation of CS with an eye on the most frequent cortisol-related comorbidities and discuss the main pitfalls of first- and second-line tests in endogenous hypercortisolism diagnostic workup
"For the service of the most August and of the Public". Expropriations and the building of the mercantile spaces in Trieste in the XVIIIth century
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Pituitary-adrenal axis and peripheral cortisol metabolism in obese patients
No full textBackground and aim: A close relationship between adiposity and increased cortisol levels is well established in patients with endogenous hypercortisolism. Nevertheless, hypothalamic-pituitary-adrenal (HPA) axis regulation in overweight subjects is still a matter of concern. We studied free cortisol (urinary free cortisol, UFC and late night salivary cortisol, LNSC), pituitary feedback (serum cortisol after 1 mg dexamethasone suppression test, 1 mg DST) and peripheral cortisol metabolism (urinary cortisol to cortisone ratio, F/Eratio) in a large series of overweight subjects without Cushing’s Syndrome. Materials and methods: We considered 234 patients divided in 5 BMI classes, matched for age and gender (BMI ≤ 25 kg/m2n = 38; 25–30 n = 58; 30–35 n = 52; 35–40 n = 52; >40 n = 34). UFC, LNSC and urinary F/Eratio were assessed with LC-MS. Results: We collected 183 LNSC, 176 UFC, 152 1 mg DST and 64 F/Eratio tests. UFC levels were higher in lean subjects, and they decreased according to the BMI classes (p = 0.022). Non-suppressed cortisol levels (>50 nmol/L) after 1 mg DST were observed especially in patients with normal weight or mild obesity. Patients with BMI ≥ 35 kg/m2 revealed a reduced F/Eratio (0.39 vs. 0.61, p = 0.006). The specificity of tests (false positive results) was higher considering 1 mg DST or UFC in obese patients, on the contrary impaired cortisol rhythm (LNSC above normality) was observed in 47 subjects, irrespective of weight. Conclusions: Overweight and obese subjects are characterised by an original regulation of HPA axis (reduced UFC levels, increased suppression after 1 mg DST) and peripheral cortisol metabolism (reduced F/Eratio), suggesting an effort to counteract hypercortisolism
Frequently asked questions and answers (if any) in patients with adrenal incidentaloma
Full text linkAdrenal incidentalomas (AIs) are incidentally discovered adrenal masses, during an imaging study undertaken for other reasons than the suspicion of adrenal disease. Their management is not a minor concern for patients and health-care related costs, since their increasing prevalence in the aging population. The exclusion of malignancy is the first question to attempt, then a careful evaluation of adrenal hormones is suggested. Surgery should be considered in case of overt secretion (primary aldosteronism, adrenal Cushing's Syndrome or pheochromocytoma), however the management of subclinical secretion is still a matter of debate
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