1,720,971 research outputs found
Caracterización bioquímica parcial del veneno de las especies Micrurus medemi, Micrurus sangilensis y Micrurus lemniscatus de Colombia
Get PDFLos venenos de las serpientes del género Micrurus han sido poco estudiados debido a las dificultades existentes en su recolección, mantenimiento y bajas cantidades producidas por individuo. Los venenos de las serpientes del género Micrurus o corales verdaderas son conocidos principalmente por sus efectos neurotóxicos, de tipo postsináptico o presináptico ejerciendo un bloqueo sobre la placa neuromuscular, el cual desencadenará en el peor de los casos una parálisis respiratoria y muerte. Micrurus medemi y Micrurus sangilensis son especies endémicas de Colombia, ubicadas en la región Orinoquía y región Andina y sus venenos no han sido objeto de estudio al momento. Micrurus lemniscatus, se distribuye en la región cis-andina, en la cuenca amazónica y del Orinoco. Para esta especie se ha estudiado el veneno sólo de las poblaciones de Brasil, pero poco se conoce de las colombianas. Por medio de un abordaje bioquímico fue posible determinar que estos tres venenos presentaban variaciones interespecíficas, poseían diferentes compuestos en un amplio intervalo de masa molecular (10-133kDa), pero con un predominio de elementos 26kDa, presentaron actividad PLA2, poseen actividad hialuronidasa (entre 68 y 76kDa) y actividad proteasa la cual en general fue baja pero bien definida para el veneno de M. lemniscatus en sustrato de caseína. Los venenos redujeron la viabilidad celular en cultivo primario de neuronas hipocampales (M. lemniscatus 30%, M. medemi 50% y M. sangilensis 25%) y en línea HTB-132 de cáncer de seno (M. lemniscatus 30%, M. medemi 60% y M. sangilensis 30%). Este tipo de caracterizaciones contribuyen en la generación de conocimiento en el área de la toxinología.Abstract: The Micrurus snake’s venom has been slightly studied due to the difficulties in their collection, maintenance and low quantities produced by each animal. This are known mainly for their neurotoxic effects, postsynaptic or presynaptic, exerting a block at the neuromuscular plate, which will trigger, in worst cases, respiratory paralysis and death. Micrurus medemi and Micrurus sangilensis are endemic species from Colombia, located in the Orinoquía region and the Andean region, and have not been studied at the moment. Micrurus lemniscatus, is distributed in the cis-andean region, the Amazon basin and Orinoco basin. For this specie the venom has been studied only in Brazil, and little is known about the Colombian species. Due to a biochemical approach, was possible to determine that these three venoms showed interspecific variations, possessed different compounds in a wide range of molecular mass (10-133kDa), but with a predominance of elements less than 26kDa; presented PLA2 activity, hyaluronidase activity (between 68 and 76 kDa) and protease activity, which in general was low but well defined for the venom of M. lemniscatus in casein substrate. Venom reduced cell viability in primary culture of hippocampal neurons (M. lemniscatus 30%, M. medemi 50% and M. sangilensis 25%) and HTB-132 line of breast cancer (M. lemniscatus 30%, M. medemi 60% and M. sangilensis 30%). This type of characterization contributes to the generation of knowledge in the area of toxinology.Maestrí
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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