1,721,034 research outputs found
Flow cytometric follow-up of T-cell subsets in LAS patients during immunomodulating therapy
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Molluscum contagiosum in two HIV-positive patients. Unusual findings with immunological and therapeutical evaluation
No full textMolluscum contagiosum is a benign, often self-limiting skin disorder resulting from infection by a Pox-virus. The immunodeficiency conditions whether primary or secondary, may be associated with several viral skin infections with clinical features not usually observed. We report the clinical, therapeutical and immunological findings in two adult patients affected with molluscum contagiosum infection and the acquired immunodeficiency syndrome (AIDS). In particular the two patients showed hundreds of lesions disseminated on the face, neck and scalp; the face involvement is typical of childhood while in adults the infection is sexually transmitted and the lesions are observed in the genital area. Both cryotherapy by itself and in association with interferon α2b injections failed to produce any improvements: the lesions continued to increase in number and size. Monthly immunological assessments of the patients for a period of 1 year support earlier evidence that the molluscum contagiosum virus may act as an opportunistic pathogen. Moreover, this association between disseminated molluscum infection and HIV infection constitutes a difficult problem to handle therapeutically. This difficulty in management seems to be correlated to the absolute depletion of T helper lymphocytes typical of the late stages of AIDS
Absence of antibodies to human immunodeficiency virus in long-term institutionalized psychiatric patients.
No full textGuidelines for the prevention of cardiovascular risk in HIV-infected patients treated with antiretroviral drugs
No full textThe objective proposed by various health authorities for the year 2010 is to reduce CHD deaths to no more than 51 in 100.000, "enhancing the cardiovasclular health and quality of life of all Americans through imprevement of medical management, prevention and control of risk factors, and promotion of ehalthy lifestyle behaviors". In light of this policy also adopted by the European Union, particolar attention must be devoted to HIV-infected individuals who, in the near future, could represent an emerging population at a more elevated risk of CHD due to the prolonged life expectancy and/or metabolic disturbances induced by therapy. Elevated triglycerides (TG), low-density lipoprotein (LDL), cholesterol, very low-density lipoprotein (VLDL) cholesterol, and reduced livels of high-density lipoprotein (HDL) cholesterol are associated with body-fat redistribution characterized by visceral fat accumulation, peripheral lipodystrophy/lipoatrophy, and CHD. It has been reported that 5-75% of HIV patients receiving HAART experience a worse lipid metabolism and body-fat distribution after 10-12 months of therapy. Our guidelines, based on our own adn the experience of other, meet the intervention criteria defined by the American National Cholesterol Education Program (NCEP), including evaluation criteria, diet prescription, drug and exercise treatment - preliminary discussion included in The Pavia COnsensus Statement, October 2001, the recommendations of the HIV Medicine Association of the Infectious Disease Society of America and the Adult AIDS Clinical Trials Group (AACTG), and the 2007 updated scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity and Metabolism. Our study is also based on algorithms and approaches developed in classic phusiology and sports Medicine for healthy people, the elderly, diseases such as diabetes and CVD
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Human cytomegalovirus viremia in HIV-1 seropositive patients at various clinical stages of infection
No full textEighty-two HIV-1-seropositive subjects were examined for the presence and quantification of human cytomegalovirus (HCMV) in peripheral blood polymorphonuclear leukocytes (PMNL) by polymerase chain reaction, culture and immunofluorescence in order to investigate the relationship between viraemia and immunosuppression. Patients were divided into three groups: (1) asymptomatic subjects with greater than 400 x 10(6)/l CD4 lymphocytes (n = 30); (2) asymptomatic subjects with less than 400 x 10(6)/l of CD4 lymphocytes and zidovudine (n = 20), and (3) AIDS-related complex (ARC)/AIDS patients on zidovudine (n = 32). Evidence of HCMV infection in circulating PMNL was found in 15 out of 29 ARC/AIDS patients examined (51.7%), whereas no infection was detected among the 50 asymptomatic HIV-1-seropositive subjects. HCMV-related symptoms were found only where the number of infected PMNL was greater than 50 per 2 x 10(5) cells
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