1,058 research outputs found
Author response: Cerebello-spinal tDCS in ataxia: A randomized, double-blind, sham-controlled, crossover trial
No full textRecent breakthroughs in the understanding of frontotemporal lobar degeneration and its related disorders.
No full textAdvances in the treatment and management of frontotemporal dementia
No full textIntroduction: Frontotemporal dementia (FTD) is a complex neurodegenerative disorder, characterized by a wide range of pathological conditions associated with the buildup of proteins such as tau and TDP-43. With a strong hereditary component, FTD often results from genetic variants in three genes - MAPT, GRN, and C9orf72. Areas covered: In this review, the authors explore abnormal protein accumulation in FTD and forthcoming treatments, providing a detailed analysis of new diagnostic advancements, including innovative markers. They analyze how these discoveries have influenced therapeutic strategies, particularly disease-modifying treatments, which could potentially transform FTD management. This comprehensive exploration of FTD from its molecular underpinnings to its therapeutic prospects offers a compelling overview of the current state of FTD research. Expert opinion: Notable challenges in FTD management involve identifying reliable biomarkers for early diagnosis and response monitoring. Genetic forms of FTD, particularly those linked to C9orf72 and GRN, show promise, with targeted therapies resulting in substantial progress in disease-modifying strategies. The potential of neuromodulation techniques, like tDCS and rTMS, is being explored, requiring further study. Ongoing trials and multi-disciplinary care highlight the continued push toward effective FTD treatments. With increasing understanding of FTD's molecular and clinical intricacies, the hope for developing effective interventions grows
Endothelial nitric oxide synthase polymorphisms as risk factors for migraine: a response.
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Architetture dell'immaginario. La casa nel cinema italiano degli anni Cinquanta e Sessanta
No full textThe migration of cultural and visual forms from a medium to another entails the consideration of media environment as an experimental one. Since the house can be thought over as a media environment – being either constructed in the media or infiltrated by the media – it may be also considered as a space of negotiation structured by images. In this sense the domestic visual environment becomes physical, psychological and imaginary at the same time, and its analysis exacts a specific attention to the processes of re-appropriation, re-mediation and re-location underneath.
Therefore the main aim of this essay is to find out, through an interdisciplinary approach of analysis, the cultural patterns on which the visual culture of domesticity was built in Italy during the Fifties and Sixties. In fact, mapping the evolution of all the symbolic patterns allows us to detect the mutation of cultural forms concerning domesticity, including images in the field of structuring element of space.
Besides developing the analogies between architectonic and cinematographic experiences of domesticity, the study inquires into the joined influence of architecture and cinema on the popular imaginary of it, basing itself on Le Corbusier’s and Ejzenštein’s remarks about movement and perception
Brain Stimulation in Alzheimer's Disease Trials
No full textAlzheimer's disease (AD) continues to lack definitive curative therapies, necessitating an urgent exploration of innovative approaches. This review provides a comprehensive analysis of recent clinical trials focusing on invasive and non-invasive brain stimulation techniques as potential interventions for AD. Deep brain stimulation (DBS), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and transcranial alternating current stimulation (tACS) are evaluated for their therapeutic efficacy, safety, and applicability. DBS, though invasive, has shown promising results in mitigating cognitive decline, but concerns over surgical risks and long-term effects persist. On the other hand, non-invasive methods like rTMS, tDCS, and tACS have demonstrated potential in enhancing cognitive performance and delaying disease progression, with minimal side effects, but with varied consistency. The evidence hints towards an individualized, patient-centric approach to brain stimulation, considering factors such as disease stage, genetic traits, and stimulation parameters. The review also highlights emerging technologies and potential future directions, emphasizing the need for larger, multi-center trials to confirm preliminary findings and establish robust clinical guidelines. In conclusion, while brain stimulation techniques present a promising avenue in AD therapy, further research is imperative for more comprehensive understanding and successful clinical implementation. Through this review, we aim to catalyze the scientific discourse and stimulate further investigation into these novel interventions for AD
Editorial [Hot Topic: Frontotemporal Lobar Degeneration and Related Disorders (Guest Editor: Barbara Borroni)]
No full textThe usefulness of biological and neuroimaging markers for the diagnosis of early-onset Alzheimer's disease.
No full textThe recent proposed criteria for Alzheimer's Disease (AD) have strongly claimed the usefulness of biological and neuroimaging markers for early identification AD. Cerebrospinal fluid (CSF) Tau/Abeta ratio, hippocampal atrophy, posterior cingulate, and neocortical associative area hypometabolism, or amyloid burden evaluated by PiB compound, held the premises to increase diagnostic accuracy in the preclinical disease stages. Despite many efforts to identify subjects at risk of developing AD, less attention has been paid to presenile AD diagnosis. A few data are already available in early onset AD, mainly obtained in cases of monogenic disorder. In this paper, we discuss the current literature on the role of biological and neuroimaging markers in presenile AD.</jats:p
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