1,720,957 research outputs found
Role krevních destiček a antiagregační terapie u adenokarcinomu pankreatu
Get PDFAspirin as a non-steroidal anti-inflammatory drug and platelet inhibitor has been shown to reduce cancer incidence and metastatic rates and improve survival in some cancer types. This thesis explores the potential role of aspirin as an adjunct therapy in the management of pancreatic ductal adenocarcinoma (PDAC), focusing on its impact on clinical outcome. Through a retrospective study conducted at the University Hospital Hradec Králové (UHHK), data from patients diagnosed with PDAC between 2011 and 2016 were analysed to assess the correlation between long-term aspirin use and tumour operability, TNM stage and survival endpoints. The study reported that patients who had taken aspirin for two or more years prior to diagnosis were more likely to present with operable tumours and less likely to have metastatic disease at diagnosis, thereby increasing the chances of surgical intervention. However, no significant differences in overall survival, progression-free survival, or disease- free survival were observed between aspirin users and non-users, indicating that while aspirin may influence early-stage disease characteristics, its impact on long-term survival remains unclear. The findings underscore the need for further research, particularly in the form of large-scale prospective studies, to clarify the...Aspirin jako nesteroidní protizánětlivý lék a inhibitor trombocytů prokazatelně snižuje výskyt rakoviny, rychlost metastáz a zlepšuje přežití u některých typů nádorů. Tato práce zkoumá potenciální úlohu aspirinu jako adjuvantní terapie v léčbě pankreatického duktálního adenokarcinomu (PDAC), přičemž se zaměřuje na jeho vliv na klinický výsledek. Retrospektivní studie provedená ve Fakultní nemocnici Hradec Králové (FNHK) analyzovala data pacientů diagnostikovaných s PDAC v letech 2011 až 2016 s cílem posoudit korelaci mezi dlouhodobým užíváním aspirinu a operabilitou nádoru, TNM stadiem a parametry přežití. Studie ukázala, že pacienti, kteří užívali aspirin dva roky nebo déle před diagnózou, měli častěji operabilní nádory a méně často metastatické onemocnění při diagnóze, což zvyšovalo šance na chirurgický zákrok. Nicméně nebyly pozorovány významné rozdíly v celkovém přežití, přežití bez progrese onemocnění nebo přežití bez nemoci mezi uživateli a neuživateli aspirinu, což naznačuje, že i když aspirin může ovlivnit charakteristiky onemocnění v raných stadiích, jeho vliv na dlouhodobé přežití zůstává nejasný. Zjištění zdůrazňují potřebu dalšího výzkumu, zejména ve formě velkých prospektivních studií, k objasnění terapeutického potenciálu aspirinu u PDAC a jeho začlenění do standardních léčebných...Klinika onkologie a radioterapieDepartment of Oncology and RadiotherapyLékařská fakulta v Hradci KrálovéFaculty of Medicine in Hradec Králov
The Role of Platelets and Antiplatelet Therapy in Pancreatic Adenocarcinoma
No full textAspirin as a non-steroidal anti-inflammatory drug and platelet inhibitor has been shown to reduce cancer incidence and metastatic rates and improve survival in some cancer types. This thesis explores the potential role of aspirin as an adjunct therapy in the management of pancreatic ductal adenocarcinoma (PDAC), focusing on its impact on clinical outcome. Through a retrospective study conducted at the University Hospital Hradec Králové (UHHK), data from patients diagnosed with PDAC between 2011 and 2016 were analysed to assess the correlation between long-term aspirin use and tumour operability, TNM stage and survival endpoints. The study reported that patients who had taken aspirin for two or more years prior to diagnosis were more likely to present with operable tumours and less likely to have metastatic disease at diagnosis, thereby increasing the chances of surgical intervention. However, no significant differences in overall survival, progression-free survival, or disease- free survival were observed between aspirin users and non-users, indicating that while aspirin may influence early-stage disease characteristics, its impact on long-term survival remains unclear. The findings underscore the need for further research, particularly in the form of large-scale prospective studies, to clarify the..
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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