23,489 research outputs found
The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways
No full textCopyright © 2009 Elsevier Ltd All rights reserved.Mei-Chi Chang, Li-Deh Lin, Chiu-Po Chan, Hsiao-Hua Chang, Lin-I. Chen, Hsueh-Jen Lin, Hung-Wei Yeh, Wan-Yu Tseng, Po-Shuen Lin, Chiu-Chun Lin and Jiiang-Huei Jenghttp://www.elsevier.com/wps/find/journaldescription.cws_home/30392/description#descriptio
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
KK2-0130 - Wan hkru yang galaw ai lam (How people officiate when a fire breaks out)
No full textTranscription (La Ring) E anhte Jinghpaw ni moi gaw ndai e dum nta htingkrawt htingnawt wan hkru wa rai ai ten hta e anhte gaw ndai wan hpe e anhte gaw wo hka de hka danam daru de shabawn bang kau ai. Shabawn bang kau nna she La Tu Lum hte num Htu Lum ndai lahkawng yan ndai wan gang gang ai. Kawa chyen lahkawng kaw ndai wan nawn bang nna wan gang gang nna bai wan hpe e bai wut hpang la ai re. Mi na wan ni hpe yawng mare ting yawng sat kau ai. Sat kau nna she ndai wan ndai wan nhprang hpe gaw wo shabawn bang kau ai dumsa nna shabawn bang kau wo hka danam de e shabawn bang kau sa sa bang kau ngut ai hpang e she ndai La Tu Lum hte num Htu Lum e ndai yan wan gang gang la ai. Wan gang gang la na she dai wan dai chyi wa jang she mare ting gaw dai kaw na wan bai e garan la ai. Yawng nta shagu dai kaw na wan bai garan la ai hku re. Dai nrai jang gaw ndai wan hpyen ngu ai grai hkrit ra ai nga ai majaw wan hpe gaw dai nhprang wan hpe gaw wo dumsa nna shi hpe hka danam de shabawn bang kau ai hku re. E dai rai na she bai ndai la Tu Lum hte num Htu Lum yan wan gang gang nna dai kaw na wan byin wa jang she mare ting bai dai kaw na bai hta la na bai e anhte ni shadu lu shadu sha ju lu ju sha rai wa ai hku re. Dai majaw wan hte seng ai gaw e dai hku re anhte Jinghpaw ni moi na htung gaw dai hku re. . Language as given: Jinghpa
Coping with crises in (post-)developmental urbanization: the case study of Songdo International City, South Korea
No full textThis chapter examines the underlying political economy of megaproject promotion during times of post-crisis recovery, using the case study of Songdo International City in Incheon, South Korea. This large-scale urban development project, built on reclaimed land, is widely acclaimed as Korea’s first foreign-led urban development project. However, Songdo should be understood as a conjunctural space where various domestic and foreign actors have interacted to pursue their material goals throughout different historical contexts. In particular, the two economic crises that hit Korea in 1997 and 2008 were significant impetuses that led to shifts in the dynamics among different scalar actors. By investigating the consequences of these two crises on the development of Songdo, this chapter aims to show how various multiscalar urbanization actors engaged in the urban megaproject and how their dynamics shifted over time. In doing so, this chapter illustrates how speculative interests at different scales became dominant in the development process of Songdo International City
The political economy of megaprojects in Asia: state power, land control, financial flows, and dispossession
No full textThis book offers a comprehensive analysis of how the developmental goals of Asian states are reflected in large-scale projects and how various actors both realize and challenge these goals. The rise of Asian economies has spurred the proliferation of megaprojects through large-scale resource mobilization, necessitating varying degrees of state intervention. Despite neoliberal pressures, these projects remain linked to national developmental aspirations, driven by domestic, transnational, or combined pro-growth interests, and serve multiple political purposes. The book advances the argument that megaprojects embody the dynamics of multiscalar strategic relations that determine the process and outcome of urbanization. These projects create iconic landmarks, new towns, central business districts, and infrastructure, showcasing intertwined political and economic interests. By examining contemporary megaprojects in China, South Korea, Taiwan, India, Malaysia, and Turkey, the contributing authors reveal the complexity of urbanizing forces and their multiscalar nature in shaping the built environment and shed light on the intricate interplay of state strategies, economic needs, and sociopolitical forces that influence urban landscapes. This interdisciplinary work provides a nuanced understanding of the political economy underpinning Asian urbanization and contributes to ongoing debates on urban development, state-society relations, and the production of space in the context of globalization
Chapter 1 Situating Megaprojects in Asia's Political Economy of Urbanization
No full textThis book offers a comprehensive analysis of how the developmental goals of Asian states are reflected in large-scale projects and how various actors both realize and challenge these goals. The rise of Asian economies has spurred the proliferation of megaprojects through large-scale resource mobilization, necessitating varying degrees of state intervention. Despite neoliberal pressures, these projects remain linked to national developmental aspirations, driven by domestic, transnational, or combined pro-growth interests, and serve multiple political purposes. The book advances the argument that megaprojects embody the dynamics of multiscalar strategic relations that determine the process and outcome of urbanization. These projects create iconic landmarks, new towns, central business districts, and infrastructure, showcasing intertwined political and economic interests. By examining contemporary megaprojects in China, South Korea, Taiwan, India, Malaysia, and Turkey, the contributing authors reveal the complexity of urbanizing forces and their multiscalar nature in shaping the built environment and shed light on the intricate interplay of state strategies, economic needs, and sociopolitical forces that influence urban landscapes. This interdisciplinary work provides a nuanced understanding of the political economy underpinning Asian urbanization and contributes to ongoing debates on urban development, state–society relations, and the production of space in the context of globalization
Spiniphilus spinicornis Lin & Bi 2011
No full textSpiniphilus spinicornis Lin & Bi, 2011 (Figs. 1 & 3) Spiniphilus spinicornis Lin & Bi, 2011: 55, figs. 1–2. Remarks. There is a mistake in Lin & Bi (2011). Fig. 9 a is dorsal view while Fig. 9 b is ventral view. Distribution. China: Yunnan. Material examined. Holotype (26.0 mm long), male, China, Yunnan Prov., Yingjiang (24 ° 46 ′N, 97 ° 58 ′E), 1700 m, 1980. IV. 15, leg. Ping Gao (IZAS, IOZ (E) 1859320). Paratypes: 1 female (37.0 mm long), same data as holotype but 1980. IV. 21, IOZ (E) 1859322; 2 males, Yunnan prov., Tengchong County, Longchuanjiang (24 ° 55 ′N, 98 ° 42 ′E), alt. 1050 m, 2006. V. 16, leg. Ping Zhao by light trap (IZAS, IOZ (E) 1859321 & CCCC). Additional material. 2 males, Yunnan, Tengchong County, Mt. Laifengshan (25.019 °N, 98.485 °E), alt. 1700 m, 2011. V. 6, leg. Wan-Gang Liu (IZAS, specimens in alcohol, with one male sent to Petr Švácha for molecular study).Published as part of Bi, Wenxuan & Lin, Meiying, 2015, Discovery of second new species of the genus Spiniphilus Lin & Bi, and female of Heterophilus scabricollis Pu with its biological notes (Coleoptera: Vesperidae: Philinae: Philini), pp. 575-583 in Zootaxa 3949 (4) on page 576, DOI: 10.11646/zootaxa.3949.4.7, http://zenodo.org/record/24151
Achievable degrees-of-freedom by distributed scheduling in an (n, K)-user interference channel
No full textJiao hui xin bao.
No full textOn vol. 10 A: With editor's presentation inscription on final page.Also available in photocopy by Hua wen shu chü, Taipei, 1968. in series of Chʻing mo min chʻu pao kʻan tsʻung pien chih 3.Superseded by Wan kuo kung pao, 1874-1907.Ed. by Young John Allen.Mode of access: Internet.Adrian A. Bennett. Research guide to the Chiao hui hsin pao (The church news)
Scytinopogon Lin & Wang & Hsieh 2022
No full textKey to Scytinopogon species (update from Furtado et al. 2021) 1. Hymenophore becoming more or less minutely papillate or hydnoid.................................................................................. S. scaber 1. Hymenophore smooth........................................................................................................................................................................2 2. Basidiomes light brown to reddish brown when fresh.......................................................................................................................3 2. Basidiomes pure white to pale yellow when fresh............................................................................................................................ 4 3. Basidiomes slender with flattened branches, context dry; context hyphae inflated to 6.0−23 µm diam........................... S. robustus 3. Basidiomes robust with cylindric to flattened and narrowly spathulate branches, context viscid; context hyphae 3.5–8 µm diam................................................................................................................................................................................................ S. foetidus 4. Basidiomes subfragile, reddish brown when dry; basal mycelium absent........................................................................................ 5 4. Basidiomes more robust, pale yellow when dry; basal mycelium present.........................................................................................6 5. Basidiospores subglobose; cystidial hairs on stipitipellis...................................................................................... S. caulocystidiatus 5. Basidiospores ellipsoid; no cystidial hairs on stipitipellis................................................................................................ S. dealbatus 6. Basal mycelium abundant and very compact crystals present, insoluble in KOH; basidiospores nodulose, finely verrucose..................................................................................................................................................................................................... S. pallescens 6. Basal mycelium scant and loosely attached, crystals absent; basidiospores truly echinulate........................................................... 7 7. 1−2-spored or 4-spored basidium................................................................................................................................... S. chartaceus 7. 4-spored basidium.................................................................................................................................................. S. cryptomerioidesPublished as part of Lin, Wan-Rou, Wang, Pi-Han & Hsieh, Sung-Yuan, 2022, Scytinopogon cryptomerioides (Hydnodontaceae), a new species from Taiwan, pp. 73-83 in Phytotaxa 552 (1) on page 81, DOI: 10.11646/phytotaxa.552.1.6, http://zenodo.org/record/667326
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