1,720,974 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Using next generation sequencing to detect clinically relevant oncogene mutations in lung cancer
No full textIntroduction: Modern care of patients with lung cancer requires rapid and accurate diagnosis leading to personalized therapies for individual patients based on molecular characteristics of their tumour. Detecting mutations that predict response to drug quickly and accurately is an essential part of this process. Next generation sequencing (NGS) technologies provide an alternative approach for detecting mutated oncogenes in cancer. We hypothesize that NGS is equal if not superior to standard methods for identifying targetable mutations in the EGFR and ALK genes in lung cancer.
Methods: DNA and RNA from 38 formalin fixed paraffin embedded lung cancer samples (37 non-small cell lung cancer (NSCLC) and one small cell lung cancer (SCLC)) archived in Diagnostic Services Manitoba were collected and analyzed using gene enrichment methods from Archer Diagnostics followed by sequencing on the Illumina MiSeq NGS machine. Targeted DNA sequencing to detect the EGFR mutation was performed on 19 samples while targeted RNA sequencing was applied to 20 samples to identify the ALK gene rearrangement. The NGS results were compared with and confirmed by current clinical standard molecular tests for EGFR (real-time PCR) and ALK (immunohistochemistry and FISH).
Results: Three cases were positive for the EGFR mutation and two other samples harbored the EML4-ALK fusion genes as determined by NGS. The concordance between NGS and real-time PCR for EGFR mutation detection was 88.9%. Additionally, the NGS methodology also provided profiles of other genes commonly mutated in NSCLC including KRAS and TP53. The consistency for ALK fusion testing was 100% between NGS and FISH.
Conclusion: This study provides support that NGS is a promising diagnostic tool for mutation detection in NSCLC and holds strong potential for an alternative approach to identifying clinically relevant targets such as EGFR and ALK. Furthermore, NGS provides more information on cancer driven gene mutations than other traditional methods.October 201
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The role of gross and microscopic descriptions in pathology reports
No full textBackground: The implementation of mandatory synoptic templates in the final diagnosis section of pathology reports has been associated with increased uniformity and clarity though the content and format of other pathology report sections have yet to be examined. This study appears to be the first of its kind to examine the importance of gross and microscopic descriptions for pathologists and clinicians.
Methods: Survey invitations were forwarded to both pathologists and clinicians on their use and their perceived value of the gross and microscopic description sections. A retrospective review of pathology reports of the specimens most commonly submitted to pathology was then performed to determine the elements currently included in/ omitted from microscopic descriptions.
Results: Overall, the majority of pathologists indicated they at least usually read the gross descriptions of biopsies (73.59%) and excisional specimens (91.18%) but rarely felt that microscopic descriptions should be included for biopsies (81.25%) nor excisional specimens (78.13%). Pathologists also indicated they believed gross and microscopic descriptions were rarely read (72.73% and 57.58% respectively), understood (54.55% and 42.42% respectively), or utilized by clinicians. However, the majority of clinicians indicated that they always read pathology reports (94.94%) and at least usually read and understood the gross (79.66% and 85.80% respectively) and microscopic descriptions (91.23% and 87.06% respectively) and found these sections valuable. The pathology report review revealed that microscopic descriptions were included most frequently for renal (100%) and hepatic (45%) biopsies and dermatological excisions (53.85%) and consisted of histological descriptions and ancillary studies of the respective tissues. Other specimen types including pulmonary, and breast biopsies along with gynecological excisions included this information in the comments section.
Conclusion: In summary, pathologists are advised to be cognizant that clinicians read and find value in the gross and microscopic description sections. Furthermore, there appears to be a discordance between where elements are included in pathology reports depending on specimen type. For increased consistency and clarity, it is recommended that elements be included in designated sections across all specimen types.October 202
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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