1,133 research outputs found

    Data for: Virtual Nondestructive Evaluation of Anisotropic Plates by Implementing Symmetry Informed Sequential Mapping of Anisotropic Green’s function (SISMAG)

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    No data should be used without permission from the corresponding the author. With permission, data can be used for only non-commercial purposes

    Sourav_OpenPracticesDisclosure_new – Supplemental material for A Protracted Sensitive Period Regulates the Development of Cross-Modal Sound–Shape Associations in Humans

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    Supplemental material, Sourav_OpenPracticesDisclosure_new for A Protracted Sensitive Period Regulates the Development of Cross-Modal Sound–Shape Associations in Humans by Suddha Sourav, Ramesh Kekunnaya, Idris Shareef, Seema Banerjee, Davide Bottari and Brigitte Röder in Psychological Science</p

    Sourav_SupplementalMaterial_rev – Supplemental material for A Protracted Sensitive Period Regulates the Development of Cross-Modal Sound–Shape Associations in Humans

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    Supplemental material, Sourav_SupplementalMaterial_rev for A Protracted Sensitive Period Regulates the Development of Cross-Modal Sound–Shape Associations in Humans by Suddha Sourav, Ramesh Kekunnaya, Idris Shareef, Seema Banerjee, Davide Bottari and Brigitte Röder in Psychological Science</p

    Hamburg Open Science Award 2020 | Project Video with Scripts | A Protracted Sensitive Period Regulates the Development of Cross-Modal Sound–Shape Associations in Humans

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    Project videos (DE/EN) accompanying the awarding ceremony of Hamburg Open Science Award 2020. This project was one of the winners in the "Research Projects" category. Video scripts (DE/EN) are attached as pdf files, and can be used for subtitle generation in platforms not supporting closed captions. Visual elements in the video have been described in the scripts. Original publication: Sourav, S., Kekunnaya, R., Shareef, I., Banerjee, S., Bottari, D., & Röder, B. (2019). A protracted sensitive period regulates the development of cross-modal sound–shape associations in humans. Psychological science, 30(10), 1473-1482. https://doi.org/10.1177/095679761986662

    A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins

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    Fam20C is an atypical kinase implicated in bio-mineralization and phosphate homeostasis disorders, and has recently been shown to account for the activity of an orphan enzyme ("genuine casein kinase", G-CK) previously characterized for its ability to phosphorylate casein and a plethora of secreted proteins at serine residues specified by the S-x-E/pS motif. Fam20C/G-CK activity is only appreciable in the presence of high Mn2 + concentration (&gt; 1 mM), and is negligible if Mn2 + is replaced by physiological Mg2 + concentrations. Here we show that sphingosine (but not its biological precursor ceramide) not only stimulates several-fold Fam20C activity in the presence of Mn2 +, but also confers a comparable activity to Fam20C assayed with Mg2 +. Activation by sphingosine is evident using a variety of substrates, and is accounted for by both higher Vmax and decreased Km(ATP), as judged from kinetics run with the β(28-40) substrate peptide and a physiological substrate, BMP-15. Sphingosine also protects Fam20C from thermal inactivation. Consistent with the in vitro results, by treating Fam20C expressing HEK293T cells with myriocin, a potent inhibitor of the sphingosine biosynthetic pathway, the activity of Fam20C released into the conditioned medium is substantially decreased corroborating the concept that sphingosine (or related metabolite(s)) is a co-factor required by Fam20C to optimally display its biological functions. None of the small molecule kinase inhibitors tested so far were able to inhibit Fam20C. Interestingly however fingolimod, an immunosuppressive drug structurally related to sphingosine, used for the treatment of multiple sclerosis, is a powerful activator of Fam20C, both wild type and its pathogenic, loss of function, T268M mutant. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases.</p

    Design and implementation of a visual interface for conflicts-of-interest management in peer review venues

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    Peer Review Conference venues are being hosted for both computer scientists and engineers to perform peer reviews on each other's works. To uphold the integrity of this process, it is crucial to minimize Conflict of Interest (COI) between an author and a peer-reviewer pair. To address this, Sourav S. Bhowmick, an associate professor at Nanyang Technological University (NTU), developed a novel data-driven system called CLOSET (COI Finder) to detect unreported COI violations for a given conference venue. This project aims to leverage the output generated by COI Finder, providing users with the tools to visualize, analyze, and manage any potential COI between authors and reviewers for a given conference venue.Bachelor's degre

    (Table 1) Major, minor and trace element concentrations of the spheroidally-weathered diabase samples and the un-weathered rock sampled near Yeragumballi, southern India

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    Major, trace element concentrations and Nd, Sr isotope ratios were measured in micro-drilled samples of a 237 Ga-old, hand-specimen sized spheroidally weathered diabase from southern India. A sample of the un-weathered diabase dike was also analyzed. X-ray micro-CT imaging of the weathered sample shows three dominant mineral phases which are plagioclase, pyroxene, and a Fe-bearing phase (possibly hematite and/or ilmenite). This imaging documents the pervasive nature of two generations of ribbon-like, cross-cutting fractures. The older fracture is sealed while the more recent fracture is open without any in-filling. The values of the Chemical Index of Alteration (CIA) of the samples show a wide range but are less than 50. Despite being a relatively less weathered rock, we observe that concentrations of major, minor and trace elements vary significantly with the percentage relative standard deviation (%RSD) for the elements ranging from 10.2-41.8. The CIA of the samples do not show any trend with the position of the sample in the hand-specimen. Barring Ca and Li, whose concentrations decrease from the core to the rim of the sample, there is no significant spatial trend in the concentrations of the elements. Concentrations of Na, Al, and Sr increase with increasing CIA values while concentrations of Mg, Fe, and Sc decrease with increasing CIA. The strong positive correlations of Na and Al, as well as Na and Sr indicates preferential weathering of plagioclase in the diabase. Na/Ca increases while Mg/Al, Mg/Na, Mg/Ca, Fe/Al and Sc/Sr decrease with increasing CIA values and the un-weathered rock plots in the, middle of these trends. Such variations are explained in terms of differential weathering of plagioclase (in samples with lower CIA than the un-weathered rock, W1-type) and pyroxene (in samples with higher CIA than the un-weathered rock, W2-type) which have varying resistance to weathering. At the hand-specimen scale, the variability in the weathering indices like CIA are controlled by differential weathering of minerals and might not accurately reflect the intensity of weathering. Chondrite-normalized La/Sm and Gd/Lu co-vary with CIA values indicating mobility of the REEs during spheroidal weathering even at the hand-specimen scale. The Eu anomaly also increases with increasing CIA values which is explained by differential weathering of pyroxene and plagioclase. We observe large percentage deviations of the Nb-normalized concentrations of elements from the un-weathered rock in specific samples but no spatial trend is observed. Overall, the variations in element concentrations can be explained by varying fluid mobility of the elements, selective weathering of the minerals in the diabase, and ambient environmental conditions. Considerable Nd and Sr isotopic variability is observed at the hand-specimen scale and is explained in terms of weathering-related fractionation of parent/daughter ratios. This elemental fractionation must have happened long time ago to allow for radiogenic decay of the long-lived isotopes of Rb-87 and Sm-147. The spread (%RSD) in the initial Sr and Nd isotope compositions of the weathered samples reach a minimum value around 12-13 Ga which we interpret as the timing of the peak weathering event which led to fractionation of the parent/daughter ratios. For Nd isotopes, the average epsilon Nd ((1.2 Ga)) of the weathered samples coincides with the epsilon Nd-(1.2 Ga) of the unweathered rock. The timing of the weathering event coincides with the timing of the breakup of the Columbia supercontinent and follows wide-spread alkaline volcanism in the Indian subcontinent. This is the first such attempt to determine the timing of a weathering event in rocks using long-lived radioactive isotopes. (C) 2016 Elsevier B.V. All rights reserved

    A Content Analysis of the Leadership Styles of Steve Waugh and Sourav Ganguly: Leadership Lesson from the Game of Cricket

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    In this study, the researchers focus on the leadership styles of two of the game of Cricket’s most charismatic leaders of the twenty-first century – Steve Waugh of Australia and Sourav Ganguly of India in a bid to relate their styles with classic leadership theories. Both Waugh and Ganguly have been arguably recognized as the most successful cricket captains of their respective countries and have earned accolades from cricket pundits as brilliant leaders of men. In this study, a content analysis of the articles about these two legendary captains published in the highly-acclaimed Wisden almanac, electronic media such as Sportstar, Cricinfo Magazine and standard newspapers of India, Australia and other neutral countries was undertaken. The content analysis of eighty-seven articles spreading over a page length of 127 A-4 size papers revealed Waugh to be a more result-driven autocratic leader who led more by example, while Ganguly showed traits of a transformational leader who led by motivating his teammates. The study is expected to contribute to the existing body of leadership research with some new knowledge of the construct of leadership, which have been discussed at length in this paper

    Two Introductory Lectures on High-Energy QCD and Heavy-Ion Collisions

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    These introductory lectures present a broad overview of the physics of high parton densities in QCD and its application to our understanding of the early time dynamics in heavy-ion collisions
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