1,721,163 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Mahanine Disrupts Androgen Receptor Signaling in Human Prostate Cancer Cells
No full textPh.D.Continued reliance on androgen receptor (AR) signaling is an established hallmark of prostate cancer and castration-resistant prostate cancer (CRPC). Recent findings implicate the androgen receptor splice variant, ARv7 in CRPC progression, and increasing evidence suggests that targeting both, the full-length AR and its splice variant ARv7 can have beneficial therapeutic outcomes in patients with CRPC. Mahanine is a novel carbazole alkaloid derived from the leaves of Murraya koenigii, commonly known as the curry leaf plant, which grows widely across East Asia. We show here that mahanine inhibits ligand-dependent and ligand-independent AR transactivation, leading to a prominent decline in AR target gene expression. Mahanine treatment causes a time- and dose- dependent decline in AR protein levels, including truncated AR splice variants such as ARv7, in a panel of androgen-responsive and androgen-independent prostate cancer cells. The decrease in AR levels induced by mahanine occurs post-translationally by proteasomal degradation, without any change in AR gene expression. Mahanine treatment induces an outward movement of the AR from the nucleus to the cytoplasm, leading to an initial rise in cytoplasmic AR levels, followed by a gradual decline in the AR levels in both cellular compartments. Ligand-induced AR phosphorylation at Ser-81, a phospho-site associated with prostate cancer cell growth and AR transactivity, is greatly diminished in the presence of mahanine. The decline in AR phosphorylation at Ser-81 by mahanine occurs via the inactivation of mitotic kinase, CDK1. Additionally, by screening a library of structural analogues of mahanine we have identified a lead compound, Ked-6-187, with increased potency when compared to mahanine in its ability to disrupt AR signaling and prostate cancer cell growth. Furthermore, we found that the Ked-6-187 was more effective than second generation anti-androgens in inhibiting AR signaling and growth in androgen-independent prostate cancer cells. Collectively, these findings indicate that mahanine and its synthetic analogue, Ked-6-187 strongly disrupt androgen receptor signaling and inhibit the growth of androgen-dependent and -independent prostate cancer cells and demonstrate improved therapeutic potential over second generation anti-androgens which are clinically approved for CRPC treatment
PBK promotes aggressive behavior of prostate cancer cells through upregulation of a β-catenin/TCF/LEF- and MYC-driven pro-metastasis gene expression program
No full textPh.D.A key question in prostate cancer research is how to distinguish aggressive prostate cancer from indolent neoplasms. Early treatment of aggressive cancers is essential to maximize therapeutic potential but treatment carries significant health risks and the majority of men diagnosed with prostate cancer will not die from the disease. Predictive nomograms have been developed to assess the risk of malignant progression but they are currently not robust enough to accurately recommend patients for therapy or surveillance. Biomarkers of aggressive prostate cancer are therefore urgently sought. This project aimed to evaluate the role of PDZ domain-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) in prostate cancer and to determine if PBK expression contributes to aggressive behavior of prostate cancer cells. Ectopic overexpression of PBK up-regulates the invasive ability of prostate cancer cells. Production of matrix metalloproteinases-2 and -9, which are key players in metastatic invasion, is up-regulated, and the promoters of these genes are transcriptionally activated by PBK via increased β-catenin-TCF/LEF signaling. Genetic knockdown or pharmacological inhibition of PBK function in aggressive prostate cancer cells caused reduced invasiveness and down-regulation of metalloproteinase production. We also demonstrated that PBK increases expression and transcription of the metastasis-promoting gene RANKL. This effect is mediated through PBK activity-dependent stabilization and β-catenin/TCF/LEF-induced transcription of the oncogenic transcription factor c-Myc. Analysis of human prostate cancer bone metastasis samples reveals significantly higher co-expression of PBK, MYC and RANKL, compared to non-tumor prostate and localized cancer patient samples. Finally, analysis of a large set of human prostate cancer samples and multiple, independent prostate cancer datasets revealed that PBK levels and nuclear localization are significantly associated with shorter recurrence-free survival, stage, grade and distant metastasis. Our in vitro and in situ data are in agreement that PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease, and also a potential target for the therapeutic intervention of aggressive prostate cancer in men
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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