19 research outputs found
MOLECULAR STUDIES AND PHARMACOLOGICAL ROLE OF SUTHERLANDIA FRUTESCENS
No full textAbstract: Sutherlandia (Fabaceae) are reported in literature to possess pharmacological activities. Species of Sutherlandia exhibit excellent economic medicinal value and have found in traditional medicine. It contains 11 species accepted species that are extensively used for the treatment of cancer, AIDS, diabetes and communicable disease in South Africa. During this article, literature searches performed using research project engine and database. (Google scholar, Pub Med, Science Direct.).Several phenolic compounds, flavonoids, alkaloids and triterpenoid glycoside derivatives contribute to the quantitative, chemo typic variation within and between the species as observed. The identification of those compounds using advanced chromatographic techniques (UPLCeMS) and chemo-metric analysis results in a far better understanding of the phytochemical variation of Sutherlandia which may aid in internal control of staples, phytomedicines and commercial herbal products.
Keywords: Ant diabetic, Anti-oxidant, Anti-cancer, Anti-inflammatory, Anti thrombotic, Anti –HIV, Analgesic activity, Anticonvulsant, Muscle Relaxant.
Title: MOLECULAR STUDIES AND PHARMACOLOGICAL ROLE OF SUTHERLANDIA FRUTESCENS
Author: E. Rajitha
International Journal of Novel Research in Healthcare and Nursing
ISSN 2394-7330
Vol. 9, Issue 3, September 2022 - December 2022
Page No: 217-220
Novelty Journals
Website: www.noveltyjournals.com
Published Date: 18-November-2022
DOI: https://doi.org/10.5281/zenodo.7336411
Paper Download Link (Source)
https://www.noveltyjournals.com/upload/paper/MOLECULAR%20STUDIES%20AND%20PHARMACOLOGICAL-18112022-4.pdfInternational Journal of Novel Research in Healthcare and Nursing, ISSN 2394-7330, Novelty Journals, Website: www.noveltyjournals.co
Molecular cloning and sequence of retinoid X receptor in the green crab Carcinus maenas: a possible role in female reproduction
No full textRetinoid X receptor (RXR) belongs to an ancient superfamily of nuclear hormone receptors, and plays an important role in reproduction of vertebrates. However, the reproductive role of RXR has not been clarified in crustaceans. In this investigation, we first report the cloning of two alternative splice variants of RXR cDNA from green crab ovarian RNA. RXR mRNA levels were quantified in different vitellogenic stages of the crab hepatopancreas (HP) and ovary. The expression of RXR mRNA relative to the arginine kinase mRNA was significantly increased in the HP of vitellogenic crabs in a stage-dependent manner. The relative levels of RXR mRNA in the ovary were significantly lower in vitellogenic stage III crabs than in crabs in the other three stages. These data indicate that the HP and ovary of the crab are capable of expressing RXR, which may regulate, in part, vitellogenesis in the crab. We also examined the effects of methyl farnesoate (MF) and RXR-dsRNA treatments on vitellogenin and RXR gene expression. Vitellogenin and RXR mRNA levels in HP and ovarian fragments incubated in MF were significantly (P<0.001) higher than in control tissue fragments prepared from the same animal. Treatment of crabs with RXR-dsRNA significantly (P<0.001) reduced mRNA levels for RXR and for vitellogenin as well as MF levels in hemolymph. These results indicate that, MF and RXR form a complex (MF–RXR) directly and together stimulate ovarian development in these green crabs. This interaction of RXR, MF, and ovary development axis is a novel finding and is the first report to the best of our knowledge.</jats:p
Reinforcement learning based traffic optimization at an intersection with GLOSA
No full textTraffic flow optimization at an intersection helps to maintain a smooth urban traffic flow. It can reduce travel time and emission. Regularly, new algorithms are introduced to control approaching vehicles and traffic light phases. Reinforcement learning and traffic optimization is a novel combination that is used by the research community. This thesis suggests a methodology to reduce travel time and emission of vehicles for a specific intersection design. Here the author provides a clear solution by considering the driving route of approaching the vehicle to the intersection. By using reinforcement learning and route information, this research suggests a vehicle ordering mechanism in order to improve the throughput of the intersection. Before proposing the solution, the author gives a thorough research review of previous studies. Various findings regarding various Reinforcement learning algorithms and how it has used to traffic optimization are explained in Literature review. Further, the author is using GLOSA as a baseline to evaluate the new solution. Several types of GLOSA variations are discussed in this report. A new approach, which can be seen as an extension of the existing GLOSA algorithms, is described in the concept chapter. A deep Q network approach and a rule-based policy are introduced as the solution. The proposed solution was implemented and evaluated. The author was able to achieve promising results from a rule-based policy approach. Further, the issues related to both approaches were discussed in detail and solutions were given to further improve the proposed solutions
Abstract 4416: Combination of HSP90 and proteasome inhibitor is effective in pancreatic cancer
No full text
Abstract 205: BBI-608 enhances the activity of chemoradiotherapy in colorectal cancer pre-clinical models
No full textAbstract 205: BBI-608 enhances the activity of chemoradiotherapy in colorectal cancer pre-clinical models
No full textNovel Low Temperature Processing for Enhanced Properties of Ion Implanted Thin Films and Amorphous Mixed Oxide Thin Film Transistors
No full textabstract: This research emphasizes the use of low energy and low temperature post processing to improve the performance and lifetime of thin films and thin film transistors, by applying the fundamentals of interaction of materials with conductive heating and electromagnetic radiation. Single frequency microwave anneal is used to rapidly recrystallize the damage induced during ion implantation in Si substrates. Volumetric heating of the sample in the presence of the microwave field facilitates quick absorption of radiation to promote recrystallization at the amorphous-crystalline interface, apart from electrical activation of the dopants due to relocation to the substitutional sites. Structural and electrical characterization confirm recrystallization of heavily implanted Si within 40 seconds anneal time with minimum dopant diffusion compared to rapid thermal annealed samples. The use of microwave anneal to improve performance of multilayer thin film devices, e.g. thin film transistors (TFTs) requires extensive study of interaction of individual layers with electromagnetic radiation. This issue has been addressed by developing detail understanding of thin films and interfaces in TFTs by studying reliability and failure mechanisms upon extensive stress test. Electrical and ambient stresses such as illumination, thermal, and mechanical stresses are inflicted on the mixed oxide based thin film transistors, which are explored due to high mobilities of the mixed oxide (indium zinc oxide, indium gallium zinc oxide) channel layer material. Semiconductor parameter analyzer is employed to extract transfer characteristics, useful to derive mobility, subthreshold, and threshold voltage parameters of the transistors. Low temperature post processing anneals compatible with polymer substrates are performed in several ambients (oxygen, forming gas and vacuum) at 150 °C as a preliminary step. The analysis of the results pre and post low temperature anneals using device physics fundamentals assists in categorizing defects leading to failure/degradation as: oxygen vacancies, thermally activated defects within the bandgap, channel-dielectric interface defects, and acceptor-like or donor-like trap states. Microwave anneal has been confirmed to enhance the quality of thin films, however future work entails extending the use of electromagnetic radiation in controlled ambient to facilitate quick post fabrication anneal to improve the functionality and lifetime of these low temperature fabricated TFTs.Dissertation/ThesisPh.D. Materials Science and Engineering 201
Susceptor Assisted Microwave Annealing Of Ion Implanted Silicon
No full textabstract: This thesis discusses the use of low temperature microwave anneal as an alternative technique to recrystallize materials damaged or amorphized due to implantation techniques. The work focuses on the annealing of high-Z doped Si wafers that are incapable of attaining high temperatures required for recrystallizing the damaged implanted layers by microwave absorption The increasing necessity for quicker and more efficient processing techniques motivates study of the use of a single frequency applicator microwave cavity along with a Fe2O3 infused SiC-alumina susceptor/applicator as an alternative post implantation process. Arsenic implanted Si samples of different dopant concentrations and implantation energies were studied pre and post microwave annealing. A set of as-implanted Si samples were also used to assess the effect of inactive dopants against presence of electrically active dopants on the recrystallization mechanisms. The extent of damage repair and Si recrystallization of the damage caused by arsenic and Si implantation of Si is determined by cross-section transmission electron microscopy and Raman spectroscopy. Dopant activation is evaluated for the As implanted Si by sheet resistance measurements. For the same, secondary ion mass spectroscopy analysis is used to compare the extent of diffusion that results from such microwave annealing with that experienced when using conventional rapid thermal annealing (RTA). Results show that compared to susceptor assisted microwave annealing, RTA caused undesired dopant diffusion. The SiC-alumina susceptor plays a predominant role in supplying heat to the Si substrate, and acts as an assistor that helps a high-Z dopant like arsenic to absorb the microwave energy using a microwave loss mechanism which is a combination of ionic and dipole losses. Comparisons of annealing of the samples were done with and without the use of the susceptor, and confirm the role played by the susceptor, since the samples donot recrystallize when the surface heating mechanism provided by the susceptor is not incorporated. Variable frequency microwave annealing was also performed over the as-implanted Si samples for durations and temperatures higher than the single frequency microwave anneal, but only partial recrystallization of the damaged layer was achieved.Dissertation/ThesisM.S. Materials Science and Engineering 201
