115,717 research outputs found
Cell-cycle molecules in mesothelioma
No full textThe cell cycle is the cascade of events that allows a growing cell to duplicate all its component and split into two daughter cells. Several studies report the importance of cell cycle proteins in the pathogenesis and the prognosis of mesothelioma. Cell cycle progression is mediated by the activation of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors grouped into two families: the INK4 inhibitors (p16, p15, p19 and p18) and the Cip/Kip inhibitors (p21, p27 and p53). This article will review the most recent data from the literature about the expression and the diagnostic and prognostic significance of cell cycle molecules in mesothelioma
A Framework for Rapid Development and Portable Execution of Packet-Handling Applications
No full textThis paper presents a framework that enables the execution of packet-handling applications (such as sniffers, firewalls, intrusion detectors, etc.) on different hardware platforms. This framework is centered on the NetVM - a novel, portable, and efficient virtual processor targeted for packet-based processing - and the NetPDL - a language dissociating applications from protocol specifications. In addition, a high-level programming language that enables rapid development of packet-based applications is presented
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Quasi-periodic solutions of the equation v_tt - v_xx + v^3 = f(v)
No full textWe consider 1D completely resonant nonlinear wave equations of the type vtt - vxx = -v3 + O(v4) with spatial periodic boundary conditions. We prove the existence of a new type of quasi-periodic small amplitude solutions with two frequencies, for more general nonlinearities. These solutions turn out to be, at the first order, the superposition of a traveling wave and a modulation of long period, depending only on time
Forum Non Conveniens and Transnational Litigations on Business and Human Rights: The English Court of Appeal's Decision in Limbu v. Dyson
No full textThis article examines the recent decision by the Court of Appeal of England and Wales, which rejected the application of the "forum non conveniens" doctrine in "Limbu v. Dyson". The case involves claims brought by Nepalese and Bangladeshi migrant workers alleging forced labour and abusive living conditions at Malaysian factories supplying products and components for Dyson-branded goods. Reversing a previous High Court’s ruling, the Court of Appeal determined that the claims could proceed in England, which was «clearly and distinctly the appropriate forum» to hear the case. In reaching this conclusion, the Court of Appeal gave crucial and overdue consideration to, "inter alia", the major imbalances of power affecting transnational litigation on business and human rights, as well as the role of decision-making (or the lack thereof) by anchor defendants in their place of domicile in establishing the jurisdiction of home state courts. The decision is significant as it appears to reinforce the position of overseas victims of business-related human rights abuses and potentially pave the way for important developments concerning corporate accountability for human rights harms in global supply chains
The effect of coupled dark energy on the alignment between dark matter and galaxy distributions in clusters
No full textWe investigate the effects of a coupled dark energy (cDE) scalar field on the alignment between satellites and matter distributions in galaxy clusters. Using high-resolution N-body simulations for ÃâºCDM and cDE cosmological models, we compute the probability density distribution for the alignment angle between the satellite galaxies and underlying matter distributions, finding a difference between the two scenarios. With respect to ÃâºCDM, in cDE cosmologies the satellite galaxies are less preferentially located along the major axis of the matter distribution, possibly reducing the tension with observational data. A physical explanation is that the coupling between dark matter and dark energy (DE) acts as an additional tidal force on the satellite galaxies, diminishing the alignments between their distribution and the matter one. Through a Wald test based on the generalized Ãâ¡2 statistics, the null hypothesis that the two probability distributions come from the same parent population is rejected at the 99% confidence level. It is concluded that the galaxy-matter alignment in clusters may provide a unique probe of dark sector interactions as well as the nature of DE
The XMM-Newton long look of NGC 1365: uncovering of the obscured X-ray source
No full textWe present an analysis of the extreme obscuration variability observed during an XMM–Newton 5-d continuous monitoring of the active galactic nuclei (AGN) in NGC 1365. The source was in a reflection-dominated state in the first ∼1.5 d, then a strong increase in the 7–10 keV emission was observed in ∼10 h, followed by a symmetric decrease. The spectral analysis of the different states clearly shows that this variation is due to an uncovering of the X-ray source. From this observation, we estimate a size of the X-ray source DS < 1013 cm, a distance of the obscuring clouds R∼ 1016 cm and a density n∼ 1011 cm−3. These values suggest that the X-ray absorption/reflection originates from the broad-line region clouds. This is also supported by the resolved width of the iron narrow Kα emission line, consistent with the width of the broad Hβ line
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