1,721,017 research outputs found
Vitreal and seric growth hormon in proliferative diabetic retinopathy and in control subjects.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Graves’ orbitopathy in a patient with adrenoleukodystrophy after bone marrow transplantation
No full textObjective: For many years, the treatment of X-linked childhood cerebral adrenoleukodystrophy (XALD)
consisted of hydrocortisone replacement and a mixture of short chain-fatty acids, known as ‘Lorenzo’s
oil’. Recently, bone marrow transplantation (BMT) has also been used.
Case report: We report the case of a patient affected by XALD who developed Graves’ hyperthyroidism
(GH) and Graves’ orbitopathy (GO) after BMT and who we could follow-up for 6.5 years afterwards.
Evidence synthesis: A boyaffected by XALD was treated at the age of 6 years, with awhole BMT from his
sister. One year after BMT, the transplanted patient presented TSH at the lower normal value and
3 years later he developed thyrotoxicosis. After a further 2 years, the patient developed GO, which
showed clinical evidence of reactivation 5 years after its onset as a consequence of an attempt to treat
thyrotoxicosis by means of I131 (300 MBq). Seven years after BMT, the donor showed alterations of
thyroid autoimmunity and 1 year thereafter she developed GH. She never presented GO during a
subsequent 5 year follow-up.
Conclusions: This case illustrates that autoimmunity originating from a pre-symptomatic donor can be
transferred into the host during allogeneic stem cell transplantation. In cases where autoimmune
phenomena are recognized in the donor prior to donation, alternative donors or T-cell manipulation of
the graft might be considered.
For many years, the treatment of X-linked childhood cerebral adrenoleukodystrophy (XALD) consisted of hydrocortisone replacement and a mixture of short chain-fatty acids, known as 'Lorenzo's oil'. Recently, bone marrow transplantation (BMT) has also been used.
CASE REPORT:
We report the case of a patient affected by XALD who developed Graves' hyperthyroidism (GH) and Graves' orbitopathy (GO) after BMT and who we could follow-up for 6.5 years afterwards.
EVIDENCE SYNTHESIS:
A boy affected by XALD was treated at the age of 6 years, with a whole BMT from his sister. One year after BMT, the transplanted patient presented TSH at the lower normal value and 3 years later he developed thyrotoxicosis. After a further 2 years, the patient developed GO, which showed clinical evidence of reactivation 5 years after its onset as a consequence of an attempt to treat thyrotoxicosis by means of I(131) (300 MBq). Seven years after BMT, the donor showed alterations of thyroid autoimmunity and 1 year thereafter she developed GH. She never presented GO during a subsequent 5 year follow-up.
CONCLUSIONS:
This case illustrates that autoimmunity originating from a pre-symptomatic donor can be transferred into the host during allogeneic stem cell transplantation. In cases where autoimmune phenomena are recognized in the donor prior to donation, alternative donors or T-cell manipulation of the graft might be considered
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