1,721,235 research outputs found
Letter to the editor submitted in response to "psoriasis in pregnancy: case series and literature review of data concerning exposure during pregnancy to ustekinumab"
No full textTherapeutics targeting the IL-23 and IL-17 pathway in psoriasis
No full textPsoriasis is a chronic inflammatory disease characterised by sharply demarcated erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by WHO as one of the most serious non-infectious diseases, psoriasis affects 2-3% of the global population. Mechanistically, psoriatic lesions result from hyperproliferation and disturbed differentiation of epidermal keratinocytes that are provoked by immune mediators of the IL-23 and IL-17 pathway. Translational immunology has had impressive success in understanding and controlling psoriasis. Psoriasis is the first disease to have been successfully treated with therapeutics that directly block the action of the cytokines of this pathway; in fact, therapeutics that specifically target IL-23, IL-17, and IL-17RA are approved for clinical use and show excellent efficacy. Furthermore, inhibitors of IL-23 and IL-17 intracellular signalling, such as TYK2 or ROR gamma t, are in clinical development. Although therapies that target the IL-23 and IL-17 pathway also improve psoriatic arthritis symptoms, their effects on long-term disease modification and psoriasis-associated comorbidities still need to be explored
Il fototest iterativo con ultravioletti nella diagnosi di dermatite polimorfa solare: valutazione di 94 casi
No full textBackground: polymorphous light eruption (PLE) is a common photosensitivity disorder with an estimated prevalence of 10-20%. It is characterized by non-scarring pruritic erythematous papules, vesicles and/or plaques that develop on light-exposed skin. The principal action spectrum of PLE is mainly in the UVA region, although some subjects exhibit sensitivity to UVB alone or to both UVA and UVB radiation at the same time. Diagnosis is based on clinical history, clinical manifestations and phototest. Objective: the aim of this study was to evaluate the sensitivity of the phototest in patients with a relevant history for PLE. Materials and methods: from December 2003 to September 2005 a total of 94 patients were recruited and all were phototested for the reproduction of skin lesions. The minimal erythema dose (MED) for UVB and an irradiation with UVB and UVA, were administered for five consecutive days. Results: a positive response was seen in 35.1% of this population. The main positive reactions were seen in the areas stimulated with both UVB and UVA (15.9%). The average MED value was similar in all examined patients (73.88 mJ/cm2). Conclusions: although phototesting with UVA and UVB lamps remains a useful method, it is not decisive for the diagnosis of PLE
Sun habits in the children of Southern Italy
No full textSkin cancer represents an increasingly worldwide public health problem. Because an estimated 50% to 80% of the skin's lifetime sun damage is thought to occur in childhood, it is during this critical period that excessive sun exposure is considered a risk factor for later development of skin cancer. Our objective was to investigate sun habits of children of Southern Italy. The population was a randomly selected sample of 800 parents of children who attended primary schools in Campania between December 2005 and September 2006. Interviews were conducted using a questionnaire, which provided information about sociodemographic characteristics, parents' knowledge about the risk of skin cancer, their level of education, and their and their children's sun-protection and sun-exposure habits. Our results show that 45% of the children were exposed to the sun less than 2 hours a day; it is important to notice that 71.2% often stayed in the sun from 11 am to 4 pm. About 40% of children had sunburns during holidays. These data show that prevention should imperatively be emphasized for improving sun-protection and sun-exposure habits
Global warming and its effect on dermatology and plants
No full textGlobal warming or climate tropicalization is the cause of increasing temperature and humidity in the temperate areas of Europe and North America. Climatic factors influence the emergence and reemergence of infectious diseases by shifting the geographic range of the insect vector and lengthening the reproductive cycles of insects. Climatic changes also affect disease transmission by shortening the incubation period of pathogens
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