80 research outputs found
Detailed Key Methods
No full textDetailed key methods relating to manuscript: Olcina Monica, M., Kim Ryan, K., Balanis Nikolas, G., Li Caiyun, G., von Eyben, R., Graeber Thomas, G., Ricklin, D., Stucki, M., Giaccia Amato, J., Intracellular C4BPA levels regulate NF-κB dependent apoptosis, ISCIENCE (2020), doi: https://doi.org/10.1016/j.isci.2020.101594
Detailed Key Methods
No full textDetailed key methods relating to manuscript: Olcina Monica, M., Kim Ryan, K., Balanis Nikolas, G., Li Caiyun, G., von Eyben, R., Graeber Thomas, G., Ricklin, D., Stucki, M., Giaccia Amato, J., Intracellular C4BPA levels regulate NF-κB dependent apoptosis, ISCIENCE (2020), doi: https://doi.org/10.1016/j.isci.2020.101594
Challenging the Norm? The 'EthoPolitics' of Low Cost Homeownership in Scotland
No full textInfluenced by Nikolas Rose’s concept of ‘ethopolitics’ this paper explores attitudes to home and tenure amongst low-cost homeowners in Scotland. In doing so, it seeks to highlight the contested nature of contemporary governing practices and the way in which ‘governable subjects’ can challenge, reinterpret and resist dominant policy discourses, which promote homeownership as the preferred tenure of choice, whilst simultaneously pathologising and problematising social housing.Peer reviewe
Towards Real-Time Olivary Neuron Modeling
No full textThe field of Computing has been a significant catalyst for innovation across various segments of our lives. Computational neuroscience keeps demanding increased perfor- mance to implement powerful simulators able to closely approximate brain behavior using complex mathematical models. This resulted in various High-Performance Com- puting systems able accelerate the above simulation workloads. One of the challenges is how these applications are being ported to massively parallel accelerators that requires significant time and effort for designing and debugging. This thesis primary task is to optimize an existing hardware library for neural simulation. The above library uses one of the most widely used biophysically-meaningful neuron models called Hodgkin-Huxley. The library optimizations will be performed while following a design methodology to accelerate applications on Maxeler’s Data-Flow Engines (DFEs). A DFE is an FPGA- based accelerator incorporating a top-of-the-line reconfigurable device surrounded by high bandwidth, large capacity on-card memory. This work focused in the fully ex- tended model that had room for performance improvements. The result, an optimized model that takes advantage of the FPGA capabilities and achieve up to 2.66x speed up over the previous implementation. They key to this speedup is the use of fixed-point arithmetic that provides 2x speed up compared to the optimized floating-point version. Additionally, the model is implemented in multiple kernels in such a way that can be scaled up using multiple DFEs to achieve even greater performance.Computer Engineerin
Adapting authoritarianism: institutions and co-optation in Egypt and Syria
No full textThis PhD thesis compares Egypt and Syria’s authoritarian political systems. While the tendency in social science political research treats Egypt and Syria as similarly authoritarian, this research emphasizes differences between the two systems with special reference to institutions and co-optation. Rather than reducibly understanding Egypt and Syria as sharing similar histories, institutional arrangements, or ascribing to the oft-repeated convention that “Syria is Egypt but 10 years behind,” this thesis focuses on how events and individual histories shaped each states current institutional strengthens and weaknesses. Specifically, it explains the how varying institutional politicization or de-politicization affects each state’s capabilities for co-opting elite and non-elite individuals.
Beginning with a theoretical framework that considers the limited utility of democratization and transition theoretical approaches, the work underscores the persistence and durability of authoritarianism. Chapter two details the politicized institutional divergence between Egypt and Syria that began in the 1970s. Chapter three and four examines how institutional politicization or de-politicization affects elite and non-elite individual co-optation in Egypt and Syria. Chapter five discusses the study’s general conclusions and theoretical implications.
This thesis’s argument is that Egypt and Syria co-opt elites and non-elites differently because of the varying degrees of institutional politicization in each governance system. Rather than view one country as more politically developed than the other, this work argues that Syria’s political institutions are more politicized than their Egyptian counterparts. Syria’s political arena is, thus, described as politicized-patrimonialism. Syria’s politicized-patrimonial arena produces uneven co-optation of elites and non-elites as they are diffused through competing institutions. Conversely, the Egyptian political arena remains highly personalized as weak institutions and individuals are manipulated and molded according to the president’s ruling clique. This is referred to as personalized-patrimonialism. As a consequence, Egypt’s political establishment demonstrates more flexibility in ad hoc altering and adapting its arena depending on the emergence of crises.
This study’s theoretical implications suggest that, contrary to modernization and democratization theory’s adage that institutions lead to a political development, politicized institutions within a patrimonial order actually hinder regime adaptation because consensus is harder to achieve and maintain. It is within this context that Egypt’s de-politicized institutional framework advantages its top political elite. In this reading of Egyptian and Syrian politics, Egypt’s personalized political arena is more adaptable than Syria’s. These conclusions do not indicate that political reform is a process underway in either state
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A linear mixed model approach to gene expression-tumor aneuploidy association studies
No full textAneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis. Gene expression-aneuploidy association studies have previously been conducted to explore cellular mechanisms associated with aneuploidy. However, in an observational setting, gene expression is influenced by many factors that can act as confounders between gene expression and aneuploidy, leading to spurious correlations between the two variables. These factors include known confounders such as sample purity or batch effect, as well as gene co-regulation which induces correlations between the expression of causal genes and non-causal genes. We use a linear mixed-effects model (LMM) to account for confounding effects of tumor purity and gene co-regulation on gene expression-aneuploidy associations. When applied to patient tumor data across diverse tumor types, we observe that the LMM both accounts for the impact of purity on aneuploidy measurements and identifies a new association between histone gene expression and aneuploidy
Are language production problems apparent in adults who no longer meet diagnostic criteria for attention-deficit/hyperactivity disorder?
No full textIn this study, we examined sentence production in a sample of adults (N = 21) who had had attention-deficit/hyperactivity disorder (ADHD) as children, but as adults no longer met DSM-IV diagnostic criteria (APA, 2000). This “remitted” group was assessed on a sentence production task. On each trial, participants saw two objects and a verb. Their task was to construct a sentence using the objects as arguments of the verb. Results showed more ungrammatical and disfluent utterances with one particular type of verb (i.e., participle). In a second set of analyses, we compared the remitted group to both control participants and a “persistent” group, who had ADHD as children and as adults. Results showed that remitters were more likely to produce ungrammatical utterances and to make repair disfluencies compared to controls, and they patterned more similarly to ADHD participants. Conclusions focus on language output in remitted ADHD, and the role of executive functions in language production
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