323,215 research outputs found
TELOMERASE REVERSE TRANSCRIPTASE PROMOTER MUTATIONS IN A COHORT OF ADULT GLIOMAS – CLINICOPATHOLOGICAL CORRELATES
No full textPurpose: This study characterizes diffuse gliomas (WHO grade II, III and IV) to determine the frequency of telomerase reverse transcriptase promoter (TERTp) mutations, association of TERTp mutations with other molecular alterations and to assess the role of TERTp mutation in overall survival and progression free survival in relation to histological and molecular glioma subtypes.
Methods: This study analyzed a cohort of 107 adult patients with diffuse gliomas, WHO grades II and III and glioblastoma, by immunohistochemistry for isocitrate dehydrogenase (IDH) and alpha-thalassemia/mental retardation, X-linked (ATRX) mutations, fluorescence in situ hybridization (FISH) for 1p/19q co-deletions and polymerase chain reaction (PCR) sequencing for TERTp mutation. Further, five glioma molecular sub-groups were derived using three molecular alterations and included the sub-groups with: i) IDH mutations only, ii) IDH and TERTp mutation only, iii) IDH and 1p/19q co-deletion only, iv) Triple negative and v) Triple positive.
Results: IDH mutations and 1p/19q co-deletions were individually and significantly associated with an improved progression free (p=0.001 and p=0.002 respectively) and overall survival (p=0.000 and p=0.005 respectively) in the present cohort of gliomas. TERTp mutations occurred frequently in anaplastic oligodendrogliomas (94%), oligodendrogliomas (87.5%) and glioblastomas (54%). Sub-division into molecular sub-groups showed that the triple positive tumors carried the best prognosis, followed by IDH only, triple negative and finally the TERTp mutation only tumors (p-value <0.000).
Conclusion: This indicates that sub-classification using these molecular markers separates tumors into prognostically relevant categories
Contribution of tin in electrochemical properties of zinc antimonate nanostructures: An electrode material for supercapacitors
No full textConcept of collective Nernstian-Capacitive mechanism in graphene nanosheets for electrochemical energy storage
No full textFabrication of bismuth ferrite based hybrid nanostructures: Insight into a catalytic and sensing properties for the detection of biomolecules
No full textNano-bioglass: A Versatile Antidote for Bone Tissue Engineering Problems
No full textAbstractBioactive-glass scaffolds are crucial in bone tissue engineering since they act as temporary templates for tissue regrowth, providing structural support to the cells. The enhancement of the angiogenic potential of implantable biomaterial scaffolds is receiving much attention in tissue engineering strategies. The angiogenic potential of most synthetic and natural materials used to fabricate tissue-engineered scaffolds is limited, insufficient, or even absent, numerous attempts have been made to enhance angiogenesis associated with tissue-engineered constructs, either by changing physicochemical properties or by supplementation with angiogenic factors. In order to improve the angiogenic effect of bioglass nano potash alum was incorporated to the Bioglass. Both Bioglass and alum doped Bioglass were synthesised by wet chemical method (sol-gel method) and its physiological properties were studied using TGA, XRD, FESEM, its cytocompatibility was studied by in vitro cell culture studies, and these bioglass are able to form a hydroxycarbonate apatite layer on their surface when in contact with an aqueous solution
Sunlight driven photocatalytic water splitting using nanostructured bismuth tungstate (Bi2WO6)
No full textDiffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
