1,721,913 research outputs found
Investigating dynamics in biomolecular solids by solid-state NMR
No full textSolid-state nuclear magnetic resonance (ssNMR) is a powerful non-destructive tool in the analysis of structural and dynamic properties of a variety of complex biomolecules. The vast majority of ssNMR measurements are conducted on spin-½ nuclei, such as 13C and 15N, with the aid of isotopic enrichment. In this thesis we have used 14N and 13C at natural abundance levels to study the structure and dynamics of small molecules with the view to developing these as tools with which to investigate pharmaceuticals and other biomolecular systems. Nitrogen-14 is an element ubiquitous in a vast number of APIs (active pharmaceutical ingredients), though due to the large quadrupole coupling, detection of the naturally abundant (>99%) NMR active isotope 14N poses a multitude of challenges. However, the presence of this large anisotropic interaction can be advantageous as it offers a wealth of information on the conformation and dynamics in molecular systems. This thesis focuses on exploiting the quadrupolar interaction to glean valuable insight on (1) the dynamics in a family of quaternary ammonium salts (acetylcholine salts) and (2) the influence of the membrane protein Fk-1 on the phospholipid (POPC) bilayer. Through the study of the 14N lineshape and relaxation as function of temperature, we have been able to probe the dynamics revealing that such measurements can provide valuable insights into how crystal packing and polymorphism can influence the properties of these pharmacologically important sites. We have complemented these 14N studies with natural abundance CP-MAS 13C experiments, studying the influence of temperature range on the lineshape of quaternary ammonium groups. By applying ab initio quantum mechanical calculations to newly derived crystal structures, we have been able to model the chemical exchange processes that lead to complex 13C lineshapes to further characterise the dynamics of this important pharmacophore. In an expansion of these studies, we have used 14N MAS-NMR to study the interaction of phosphatidylcholine headgroups with integral membrane proteins. Employing variable temperature studies, we have been able to use 14N NMR and complementary 2H NMR of deuterated lipids chains to investigate how integral membrane proteins interact and perturb the structure and phase behaviour of the lipid bilayer
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Antenna design for Narrowband Internet of things
No full text"Premier reference source"--Front cover.Includes bibliographical references and index."The purpose of this book is to provide an antenna design concept for Narrowband Internet of Things Applications and to discuss the variety of antenna design concepts and structures for various industrial requirements"--Antenna design for narrowband IoT : design, analysis and applications / Balachandra Pattanaik, Wollega University, Ethiopia, Manavalan Saravanan, Vel Tech Rangarajan, Dr. Sagunthala, R&D Institute of Science and Technology, India, Saravanakumar U, Muthayammal Engineering College, India, Ganesh Babu T R, Muthayammal Engineering College, India -- Cost efficient amplitude and phase antenna measurement system / Nagaraj V, Knowledge Institute of Technology, India, Prasanna Kumar Singh, Noida Institute of Engineering & Technology, India, Anju Asokan, Sri Krishna College of Technology, India, Hariharan S, Knowledge Institute of Technology, India -- Pyramid framed extremely high recurrent RFID tag antenna with polarization diversity for IoT applications utilizing characteristics mode analysis / Nagaraj V, Knowledge Institute of Technology, India, T. Vasudeva Reddy, B V Raju institute of Technology, India, Hariharan S, Knowledge Institute of Technology, India, Ramya P, Bannari Amman Institute of Technology, India.1 online resource (xxiii, 261 pages)
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
