5,718 research outputs found
Pressure-relieving properties of a intra-operative warming device
No full textUp to 25% of all pressure ulcers that develop in hospitalised patients are thought to start in the operating theatre. Pressure-relieving mattresses and/or overlays are used in operating theatres to help prevent pressure damage to vulnerable areas such as the sacrum and heels, but there is no ‘standard’ theatre mattress and different mattresses give different degrees of pressure relief. Intra-operative warming may help to reduce the risk of pressure ulceration, although previous studies have produced conflicting results. This study investigated whether use of a warming device reduced sacral and heel interface pressures in 10 healthy volunteers; comparisons were made with a standard operating table mattress, a pressure-relieving gel pad and an under-patient warming device left switched on the operating table
A Low-Cost Femtosatellite to Enable Distributed Space Missions
No full text35. D.J. Barnhart, T. Vladimirova, A.M. Baker and M.N. Sweeting. - Proceedings o
Rapporteur’s report – innovative geotechnologies for energy transition
No full textThe 9th Society for Underwater Technology (SUT) International Conference on Offshore Site Investigation and Geotechnics (OSIG) closed with a Rapporteur’s report given by the author. This paper provides a record of that report, transcribed from a video recording. The presentation slides are shown as Figures.</p
DEFRApH - Sample collection and handling procedures
No full textAll chemical and biogeochemical process in the sea are affected by the acidity of the water. Acidity is therefore fundamental property of seawater. The growing concern that the acidity of the oceans might be increasing has revealed weaknesses in our knowledge of this fundamental property and its variation in space and time. In 2008 the DEFRApH project (DEFRA contract ME4133) was initiated to provide this missing information in UK related waters. It required sampling for and analysis of the total inorganic carbon and total alkalinity content of samples. This reports documents the procedures sued for sampling. A companion document Hartman Dumousseaud and Roberts (NOC Internal Document No. 01) describes in detail the analytical procedures used and the calculation of the results
Author Correction:Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention (Nature Communications, (2019), 10, 1, (5280), 10.1038/s41467-019-13244-9)
No full textThe original version of this Article contained an error in the spelling of the author Wilma D.J. van de Berg, which was incorrectly given as Wilma D.J. van den Berg. This has now been corrected in both the PDF and HTML versions of the Article.</p
Baker (Birth, 1905-12-14)
No full textAddress: 544 Clinton St.5589/Pg. 133/1905/F W/N.Y./Ohio/Dr. D.J. JonesOriginal record filed in drawer labeled 'BAILEY-BALL'
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
Building robustness research during World War II
No full textThis study reviews research carried out in the U.K. to understand and improve the robustness of buildings when subject to blast from high explosive bombs. The work concentrates on the performance of ordinary civilian buildings, with particular emphasis on multi-storey buildings framed in either reinforced concrete or structural steelwork. At the time, some of the data was used to enhance conventional building construction, principally on Government buildings, and some was used to aide post-war hardened building construction. The two main UK researchers whose work is the basis of this paper (Professor Sir Dermot Christopherson and Professor Lord Baker) identified a number of building weaknesses that led to local or progressive collapse, including connections in steel framed buildings, as well as detailing weaknesses in reinforced concrete constructions. This paper reviews these features, as well as those that added resilience to bomb damage, with particular emphasis to the use of masonry infill panels in framed buildings. Much of the information on building performance is relevant to today's engineers engaged in the design of buildings to survive blast from terrorist attacks involving the vehicle borne improvised explosive device
'A subject torn' beside the waves: (Or: Another act of thievery passed off as borrowing)
No full text- …
