55 research outputs found
Ms Orit Gadiesh, American-Israeli strategist Chairman, Bain & Company United States of America
No full textVisit of Ms Orit Gadiesh, American-Israeli strategist Chairman, Bain & Company United States of Americ
Qigong Sensory Training for Autism: Promising Effects on Sensory Processing, Self-Regulation, and Parenting Stress
No full textAbstract
Date Presented 4/1/2017
Preliminary results of an evidence-based pilot project with young children with or at risk for autism demonstrated that Qigong Sensory Training promoted participation in everyday occupations by improving sensory processing and self-regulation by 18% and decreasing parenting stress by 30%.
Primary Author and Speaker: Orit Tal-Atzili</jats:p
Interpersonal Social Responsibility Effects on Students’ Professional Development: Longitudinal Study
No full textAbstract
Date Presented 3/30/2017
This study shows the impact of an educational structured model that facilitates students’ engagement within the community to promote the development of professional identity. Based on longitudinal analysis assessment research, we suggest an effective educational model for first-year occupational therapy students.
Primary Author and Speaker: Orit Lahav
Additional Authors and Speakers: Shira Yalon-Chamovitz</jats:p
Author Correction: Markerless tracking of an entire honey bee colony (Nature Communications, (2021), 12, 1, (1733), 10.1038/s41467-021-21769-1)
No full textThe original version of this Article omitted from the author list the fourth author Alexander S. Mikheyev, who is from the Ecology and Evolution Unit, OIST Graduate University, Okinawa, Japan, and the Research School of Biology, Australian National University, Canberra, Australia. The third author Yoann Portugal has the following additional affiliation: Ecology and Evolution Unit, OIST Graduate University, Okinawa, Japan. The fourth author Alexander S. Mikheyev and the fifth author Greg J. Stephens declare equal contributions. Consequently, the Acknowledgements, which formerly read “We thank Michael Iuzzolino, Dieu My thanh Nguyen, Orit Peleg, and Michael Smith for comments on the manuscript and code testing. This work was supported by the Okinawa Institute of Science and Technology Graduate University”, have been corrected to “We are grateful to Takahashi Ikemiya for maintaining the experimental bee colonies. We thank Michael Iuzzolino, Dieu My Thanh Nguyen, Orit Peleg, and Michael Smith for comments on the manuscript and code testing. This work was supported by the Okinawa Institute of Science and Technology Graduate University. Additional funding was provided by KAKENHI grants 16H06209 and 16KK0175 from the Japan Society for the Promotion of Science to AM”. Additionally, the Author Contributions, which formerly read “Y.P. performed the bee work and devised the imaging setup, L. H. devised the labeling tool, K.B. performed method development and data analysis, K.B. and G.S. designed the study and wrote the manuscript”, has been corrected to “Y.P. performed the bee work, Y.P. and A.M. devised the imaging setup, L.H. devised the labeling tool, K.B. performed method development and data analysis, K.B., A.M., and G.S. designed the study, K.B. and G.S. wrote the manuscript”. This has been corrected in both the PDF and HTML versions of the Article. The original version of the Supplementary information associated with this Article contained an error in the description of Supplementary Table 2, which incorrectly read “All imaging data in this study were collected in 2019”. The correct version states “2018” in place of “2019”. The HTML has been updated to include a corrected version of the Supplementary information
Interactions between the Bacteroides conjugative transposons and the plasmids and insertion elements (NBUs) they mobilize
No full textBacteroides spp. are Gram-negative obligative anaerobes that are the predominant components of the normal microflora in the human colon. Bacteroides spp. are clinically important because they are opportunistic pathogens. At present, most clinical isolates of Bacteroides are resistant to tetracycline and many have acquired resistance to other antibiotics, such as erythromycin and cefoxitin. A family of chromosomally located conjugative transposons is responsible for the spread of tetracycline resistance in the Bacteroides group and is also contributing to the spread of resistance to other antibiotics. Bacteroides conjugative transposons not only transfer themselves but also mobilize co-resident plasmids. In addition, they mediate a novel activity: excision and circularization of unlinked chromosomal insertion elements (NBUs: nonreplicative Bacteroides units). One NBU (Tn4555) carries a cefoxitin resistance determinant (cfxA). Others are cryptic at present but could acquire resistance genes later. Bacteroides conjugative transposons are thus capable of spreading antibiotic resistance genes in three different ways.In elements that are transferred by conjugation, the location of the origin of transfer (oriT or nic site) usually indicates the physical structure of the transfer intermediate. In the case of NBU1 and NBU2, I have shown that the oriT is internal, suggesting that the transfer intermediate is a covalently closed circle. Data from sequence analysis and complementation experiments indicates that although the two NBUs studied (NBU1 and NBU2) differ from each other in many ways, their mob/oriT regions are quite similar. Moreover, NBUs encode only one multifunctional Mob protein which appears to recognize and initiate mobilization of the NBU by nicking at the oriT. Mobilizable plasmids generally require at least two proteins to carry out this reaction. I also have localized the oriT of the Bacteroides conjugative transposon, \rm Tc\sp{r}Em\sp{r}DOT, which transfers itself as well as NBUs. This oriT is also internal, indicating that the transfer intermediate of the conjugative transposon, like that of NBUs, is also a circle. The mob/oriT region of the Bacteroides conjugative transposon and that of the NBUs do not share significant sequence similarity either to each other or to the mob/oriT regions of Gram-negative conjugative plasmids. Thus, the Bacteroides conjugative transposons and NBUs appear to represent new groups of recognition sequences for mob/oriT systems.Conjugative transfer mediated by the Bacteroides conjugative transposons is regulated by tetracycline. Two sets of positive regulatory genes were identified previously. The first set is rteA-rteB and the second is rteC. RteA-RteB is essential for all phenotypes associated with Bacteroides conjugative transposons, whereas RteC appears to be essential only for self-transfer. Nonetheless, I showed that RteC has some effect on mobilization of plasmids and NBUs. Sequence analysis showed previously that RteA and RteB comprise a two-component regulatory system. RteA is the putative environment sensor and RteB is the transcriptional activator. Nonetheless, RteA does not sense tetracycline. Instead, the inducer antibiotic, tetracycline, activates transcription of an operon containing rteA and rteB. Expression of rteC, which lies in a different transcription unit, requires the action of RteB. In the process of localizing the transfer (Tra) region of the Bacteroides conjugative transposon, \rm Tc\sp{r}Em\sp{r}DOT, I obtained evidence that a repressor, which probably interacts with RteC, also is involved in regulating expression of transfer genes.Made available in DSpace on 2011-05-07T14:13:42Z (GMT). No. of bitstreams: 2
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Molecular genetics of Rhodobacter sphaeroides 2.4.1: Genome structure, plasmid characterization and chromosome transfer
No full textPhysical mapping techniques were employed to construct both a physical and genetic maps of the Rhodobacter sphaeroides 2.4.1 genome. It was found that this -purple, nonsulfur photosynthetic bacterium carries two different circular chromosomes whose sizes are 3046 95 and 914 17 kb in addition to five endogenous plasmids with a total size of approximately 450 kb.The smallest, 42 kb, endogenous plasmid was observed to be self transmissible. As little as an 425 bp oriT-containing DNA fragment isolated from this plasmid was able to confer transfer, between R. sphaeroides strains, when it was cloned into an otherwise non-transmissible plasmid. The DNA sequence of this oriT containing fragment reveals an A-T rich region, several direct and inverted repeats, as well as putative IHF-binding sites.Random insertion of oriT into the R. sphaeroides 2.4.1 genome generated Hfr-like strains which exhibit a gradient of marker transfer, and has further provided classical genetic evidence for the circularity as well as the presence of two distinct chromosomal linkage groups in this bacterium.Made available in DSpace on 2011-05-07T12:38:51Z (GMT). No. of bitstreams: 2
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Molecular genetics of Rhodobacter sphaeroides 2.4.1: Genome structure, plasmid characterization and chromosome transfer
No full textPhysical mapping techniques were employed to construct both a physical and genetic maps of the Rhodobacter sphaeroides 2.4.1 genome. It was found that this -purple, nonsulfur photosynthetic bacterium carries two different circular chromosomes whose sizes are 3046 95 and 914 17 kb in addition to five endogenous plasmids with a total size of approximately 450 kb.The smallest, 42 kb, endogenous plasmid was observed to be self transmissible. As little as an 425 bp oriT-containing DNA fragment isolated from this plasmid was able to confer transfer, between R. sphaeroides strains, when it was cloned into an otherwise non-transmissible plasmid. The DNA sequence of this oriT containing fragment reveals an A-T rich region, several direct and inverted repeats, as well as putative IHF-binding sites.Random insertion of oriT into the R. sphaeroides 2.4.1 genome generated Hfr-like strains which exhibit a gradient of marker transfer, and has further provided classical genetic evidence for the circularity as well as the presence of two distinct chromosomal linkage groups in this bacterium.U of I OnlyETDs are only available to UIUC Users without author permissio
China?s challenge: The opportunities and risks that China?s booming economy provides
Get PDFThe capability of designing to very low cost, and to compete successfully in the tough Chinese market can be transformed into a competitive advantage in other markets. On the other hand, MNCs that are not successfully in China will probably not acquire these capabilities. They will be in a cost disadvantage to compete against Chinese companies in their own markets. They run the risk of becoming secondary players to Chinese companies in the world market, as those competing in the microwave-ovens market against Galanz found out the hard way. MNCs have no choice; they have to accept ?China?s challenge? to continue world players. They have to win in China or lose everywhere.China?s challenge, win in China or lose everywhere, risks to China?s future growth, China?s entrepreneurs, China?s disruptive innovation
Molecular genetic characterization of essential conjugal transfer determinants on the nopaline-type Ti plasmid from Agrobacterium tumefaciens strain C58
No full textTi plasmids of Agrobacterium tumefaciens encode a conjugal transfer system. I characterized a region, called tra, that is necessary for transfer of the nopaline-type Ti plasmid, pTiC58. tra contains the origin of conjugal transfer (oriT) and a cluster of genes the products of which are predicted to function as DNA processing and transfer components. The oriT is contained within a 260-bp intergenic region flanked by transfer genes. Analysis of Tn3HoHo1-generated mutations that abolish transfer of the Ti plasmid defined an essential region of approximately six kilobases surrounding the oriT site. Expression from lacZ fusions in the tra region indicated that there is divergent transcriptional activity on both sides of the oriT site. I determined the nucleotide sequence of 8755-bp that spans this region on pTiC58. Eight ORFs, traA-D, traF, traG, and orfX, were predicted from the sequence. Directed expression of gene products from traA, traC, traD, and traG in E. coli, confirmed that these ORFs encode proteins of the predicted sizes. Deduced amino acid sequences from tra genes showed that proteins encoded by tra are similar to other transfer proteins. I also examined the regulation of gene expression within the tra locus and found that in addition to the transcriptional activator, TraR and its coinducer, the N-acyl homoserine lactone molecule, AAI, control of gene activation in tra requires two other determinants. One regulatory determinant is the cis-acting promoter sequence, called the tra box, found in the intergenic region. This DNA sequence is required for expression of the divergent tra operons that is mediated by TraR and AAI. The second regulatory determinant is the product of the traM gene which modulates activation of tra genes mediated by TraR and AAI. Studies on activation of expression of tra genes led to the localization of the gene, traI, which is responsible for production of AAI in Agrobacterium. Finally, I used the information gathered from the characterization of the tra locus and its regulation to reconstitute the transfer regions from pTiC58 on two independently replicating plasmids as a binary conjugal transfer system.Made available in DSpace on 2011-05-07T13:03:09Z (GMT). No. of bitstreams: 2
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Breast cancer radiation therapy: A bibliometric analysis of the scientific literature
Get PDFBACKGROUND AND PURPOSE: Breast cancer is the most common malignancy in women and radiation therapy (RT) is crucial in its multimodality management. Since bibliometrics is a powerful tool to reveal the scientific literature, we decided to perform a bibliometric analysis of the literature on breast cancer radiotherapy. We explored emerging trends and common patterns in research, tracking collaboration and networks, and foreseeing future directions in this clinical setting. MATERIAL AND METHODS: The electronic Scopus database was searched using the keywords “breast cancer” and “radiotherapy” to include manuscripts published in English, between 2000 and 2021. Data analysis was performed using R-Studio 0.98.1091 software with a machine-learning bibliometric method, based on the bibliometrix R package. The most relevant authors were quantified per number and fractionalized number of authored documents. Author productivity was analysed through Lotka’s law. Bradford’s law was applied to identify the nucleus of journals focused on the addressed topic. Mainstream themes area included isolated topics (niche themes), new topics (emerging themes), hot topics (motor themes) and essential topics (basic themes). RESULTS: A total of 27 184 documents was found, mainly original articles (76 %). The annual growth rate was 6.98 %, with an increase in scientific production from 485 to 2000 documents between 2000 and 2021. Overall, 2 544 journals published ≥ 1 documents. The most relevant authors were affiliated in the United States. Surgical procedures, cancer type and treatment strategies represented basic themes, while primary systemic therapy and sentinel lymph node biopsy were emerging themes. Health-related quality of life was a niche theme, while RT techniques had high centrality. CONCLUSION: The primary interests of breast cancer radiation oncologists have evolved over time, adding safety, health related quality of life, sustainability of treatments and combination to systemic therapies to radiotherapy efficacy and effectiveness and treatment outcomes
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