1,720,957 research outputs found
Imagerie ultrasonore de la stéatose hépatique préclinique
No full textThe work of this thesis aims to improve the diagnosis of non-alcoholic fatty liver disease. This chronic inflammatory disease begins with an accumulation of fat in the liver and progresses to fibrosis and severe cirrhosis in the final stage.This disease, which is now misdiagnosed, has become a significant public health problem due to its increasing incidence and its many impacts on the lives of patients.With the development of ultrafast ultrasound, new diagnostic approaches and sensitive ultrasound modalities were introduced, such as:- The ultrasensitive Doppler reveals the blood volume of the organ.- Super-resolution to image microcirculation and quantify liver vascular density.- Elastography to reveal the elasticity and hardness of the liver.- The speed of sound and the intensity of the backscatter these two values that are dependent on the amount of fat in the liver.Using its various non-invasive ultrasonic modalities, we seek to understand and predict the evolution of steatosis in preclinical models such as mice and miniature pigs. This study will also identify the ultrasonic modality most sensitive to the context of NASH.racheLes travaux de cette thèse visent à améliorer le diagnostic de la stéatose hépatique non alcoolique, une maladie chronique inflammatoire qui commence par une accumulation du gras dans le foie et évolue vers une fibrose, puis une cirrhose sévère en dernier stade.En fait, cette maladie, qui est aujourd’hui mal diagnostiquée, est devenue un problème de santé publique important en raison de l'augmentation de son incidence et de ses nombreux impacts sur la vie des patients.Avec le développement de l’échographie ultrarapide, des nouvelles approches diagnostiques et modalités échographiques sensibles ont été introduites :- Le doppler ultrasensible qui révéle le volume sanguin de l’organe.- La super résolution pour imager la microcirculation et quantifier la densité vasculaire du foie.- L'élastographie pour révéler l'élasticité et la dureté du foie.- La vitesse du son et l'intensité du backscatter, ces deux valeurs qui sont dépendantes de la quantité du gras dans le foie.À l'aide de ses différentes modalités ultrasonores non-invasives, on cherche à comprendre et à prédire l’évolution de la stéatose dans des modèles précliniques comme la souris et le petit cochon. Ainsi que, cette étude permettra d’identifier la modalité ultrasonore la plus sensible au contexte de la NASH
Imagerie ultrasonore de la stéatose hépatique préclinique
No full textThe work of this thesis aims to improve the diagnosis of non-alcoholic fatty liver disease. This chronic inflammatory disease begins with an accumulation of fat in the liver and progresses to fibrosis and severe cirrhosis in the final stage.This disease, which is now misdiagnosed, has become a significant public health problem due to its increasing incidence and its many impacts on the lives of patients.With the development of ultrafast ultrasound, new diagnostic approaches and sensitive ultrasound modalities were introduced, such as:- The ultrasensitive Doppler reveals the blood volume of the organ.- Super-resolution to image microcirculation and quantify liver vascular density.- Elastography to reveal the elasticity and hardness of the liver.- The speed of sound and the intensity of the backscatter these two values that are dependent on the amount of fat in the liver.Using its various non-invasive ultrasonic modalities, we seek to understand and predict the evolution of steatosis in preclinical models such as mice and miniature pigs. This study will also identify the ultrasonic modality most sensitive to the context of NASH.racheLes travaux de cette thèse visent à améliorer le diagnostic de la stéatose hépatique non alcoolique, une maladie chronique inflammatoire qui commence par une accumulation du gras dans le foie et évolue vers une fibrose, puis une cirrhose sévère en dernier stade.En fait, cette maladie, qui est aujourd’hui mal diagnostiquée, est devenue un problème de santé publique important en raison de l'augmentation de son incidence et de ses nombreux impacts sur la vie des patients.Avec le développement de l’échographie ultrarapide, des nouvelles approches diagnostiques et modalités échographiques sensibles ont été introduites :- Le doppler ultrasensible qui révéle le volume sanguin de l’organe.- La super résolution pour imager la microcirculation et quantifier la densité vasculaire du foie.- L'élastographie pour révéler l'élasticité et la dureté du foie.- La vitesse du son et l'intensité du backscatter, ces deux valeurs qui sont dépendantes de la quantité du gras dans le foie.À l'aide de ses différentes modalités ultrasonores non-invasives, on cherche à comprendre et à prédire l’évolution de la stéatose dans des modèles précliniques comme la souris et le petit cochon. Ainsi que, cette étude permettra d’identifier la modalité ultrasonore la plus sensible au contexte de la NASH
Imagerie ultrasonore de la stéatose hépatique préclinique
No full textThe work of this thesis aims to improve the diagnosis of non-alcoholic fatty liver disease. This chronic inflammatory disease begins with an accumulation of fat in the liver and progresses to fibrosis and severe cirrhosis in the final stage.This disease, which is now misdiagnosed, has become a significant public health problem due to its increasing incidence and its many impacts on the lives of patients.With the development of ultrafast ultrasound, new diagnostic approaches and sensitive ultrasound modalities were introduced, such as:- The ultrasensitive Doppler reveals the blood volume of the organ.- Super-resolution to image microcirculation and quantify liver vascular density.- Elastography to reveal the elasticity and hardness of the liver.- The speed of sound and the intensity of the backscatter these two values that are dependent on the amount of fat in the liver.Using its various non-invasive ultrasonic modalities, we seek to understand and predict the evolution of steatosis in preclinical models such as mice and miniature pigs. This study will also identify the ultrasonic modality most sensitive to the context of NASH.racheLes travaux de cette thèse visent à améliorer le diagnostic de la stéatose hépatique non alcoolique, une maladie chronique inflammatoire qui commence par une accumulation du gras dans le foie et évolue vers une fibrose, puis une cirrhose sévère en dernier stade.En fait, cette maladie, qui est aujourd’hui mal diagnostiquée, est devenue un problème de santé publique important en raison de l'augmentation de son incidence et de ses nombreux impacts sur la vie des patients.Avec le développement de l’échographie ultrarapide, des nouvelles approches diagnostiques et modalités échographiques sensibles ont été introduites :- Le doppler ultrasensible qui révéle le volume sanguin de l’organe.- La super résolution pour imager la microcirculation et quantifier la densité vasculaire du foie.- L'élastographie pour révéler l'élasticité et la dureté du foie.- La vitesse du son et l'intensité du backscatter, ces deux valeurs qui sont dépendantes de la quantité du gras dans le foie.À l'aide de ses différentes modalités ultrasonores non-invasives, on cherche à comprendre et à prédire l’évolution de la stéatose dans des modèles précliniques comme la souris et le petit cochon. Ainsi que, cette étude permettra d’identifier la modalité ultrasonore la plus sensible au contexte de la NASH
Imagerie ultrasonore de la stéatose hépatique préclinique
No full textLes travaux de cette thèse visent à améliorer le diagnostic de la stéatose hépatique non alcoolique, une maladie chronique inflammatoire qui commence par une accumulation du gras dans le foie et évolue vers une fibrose, puis une cirrhose sévère en dernier stade.En fait, cette maladie, qui est aujourd’hui mal diagnostiquée, est devenue un problème de santé publique important en raison de l'augmentation de son incidence et de ses nombreux impacts sur la vie des patients.Avec le développement de l’échographie ultrarapide, des nouvelles approches diagnostiques et modalités échographiques sensibles ont été introduites :- Le doppler ultrasensible qui révéle le volume sanguin de l’organe.- La super résolution pour imager la microcirculation et quantifier la densité vasculaire du foie.- L'élastographie pour révéler l'élasticité et la dureté du foie.- La vitesse du son et l'intensité du backscatter, ces deux valeurs qui sont dépendantes de la quantité du gras dans le foie.À l'aide de ses différentes modalités ultrasonores non-invasives, on cherche à comprendre et à prédire l’évolution de la stéatose dans des modèles précliniques comme la souris et le petit cochon. Ainsi que, cette étude permettra d’identifier la modalité ultrasonore la plus sensible au contexte de la NASH.The work of this thesis aims to improve the diagnosis of non-alcoholic fatty liver disease. This chronic inflammatory disease begins with an accumulation of fat in the liver and progresses to fibrosis and severe cirrhosis in the final stage.This disease, which is now misdiagnosed, has become a significant public health problem due to its increasing incidence and its many impacts on the lives of patients.With the development of ultrafast ultrasound, new diagnostic approaches and sensitive ultrasound modalities were introduced, such as:- The ultrasensitive Doppler reveals the blood volume of the organ.- Super-resolution to image microcirculation and quantify liver vascular density.- Elastography to reveal the elasticity and hardness of the liver.- The speed of sound and the intensity of the backscatter these two values that are dependent on the amount of fat in the liver.Using its various non-invasive ultrasonic modalities, we seek to understand and predict the evolution of steatosis in preclinical models such as mice and miniature pigs. This study will also identify the ultrasonic modality most sensitive to the context of NASH.rach
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
