9 research outputs found
Adaptive Prototype Triplet Loss for Cross-Resolution Face Recognition
No full textPart 2: Image UnderstandingInternational audienceAlthough face recognition has achieved great success in many areas, cross-resolution face recognition (CRFR) still remains a challenging task due to the large domain gap between low-resolution (LR) and high-resolution (HR) images. In this paper, we propose an adaptive prototype triplet loss (APTL) for CRFR. The APTL pulls the features close to their own prototypes, and pushes them away from the prototypes of other classes. Thus, the angular distances between features and prototypes from the same class are closer than those from different classes. Furthermore, to better exploit the similarity information among different identities, we adaptively adjust the margin term in the loss. Since the proposed APTL is applied simultaneously to HR and LR features, the gap between two domains can be narrowed naturally. Experiments on LFW and SCface datasets illustrate the superiority of our method
Interpretation and Elaboration for the ARRIVE Guidelines 2.0—Animal Research: Reporting In Vivo Experiments (V)
No full textImproving the reproducibility of biomedical research results is a major challenge. Transparent and accurate reporting of the research process enables readers to evaluate the reliability of the research results and further explore the experiment by repeating it or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), provide a checklist that is applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as enhance the reliability, repeatability, and clinical translation of animal experimental results. The use of the ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and completeness of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is based on the best practices following the ARRIVE 2.0 guidelines in international journals, and it interprets, explains, and elaborates in Chinese the fifth part of the comprehensive version of the ARRIVE 2.0 guidelines published in PLoS Biology in 2020 (the original text can be found at https://arriveguidelines.org). This section includes the items 6-11 of Recommended 11 section, covering "Animal Care and Monitoring", "Interpretation/Scientific Implications", "Generalisability/Translation", "Protocol Registration", "Data Access" and "Declaration of Interests". Its aim is to promote a comprehensive understanding and use of the ARRIVE 2.0 guidelines among domestic researchers, to enhance the standardization of experimental animal research and reporting, and to promote high-quality development of experimental animal sciences and comparative medicine research in China
Insights into toxicity of polychlorinated naphthalenes to multiple human endocrine receptors: Mechanism and health risk analysis
No full textThis study explored the combined disruption mechanism of polychlorinated naphthalenes (PCNs) on the three key receptors (estrogen receptor, thyroid receptor, and adrenoceptor) of the human endocrine system. The intensity of PCN endocrine disruption on these receptors was first determined using a molecular docking method. A comprehensive index of PCN endocrine disruption to human was quantified by analytic hierarchy process and fuzzy analysis. The mode of action between PCNs and the receptors was further identified to screen the molecular characteristics influencing PCN endocrine disruption through molecular docking and fractional factorial design. Quantitative structure–activity relationship (QSAR) models were established to investigate the toxic mechanism due to PCN endocrine disruption. The results showed that the lowest occupied orbital energy (ELUMO) was the most important factor contributing to the toxicity of PCNs on the endocrine receptors, followed by the orbital energy difference (ΔE) and positive Millikan charge (q+). Furthermore, the strategies were formulated through adjusting the nutritious diet to reduce health risk for the workers in PCN contaminated sites and the effectiveness and feasibility were assessed by molecular dynamic simulation. The simulation results indicated that the human health risk caused by PCN endocrine disruption could be effectively decreased by nutritional supplementation. The binding ability between PCNs and endocrine receptors significantly declined (up to −16.45%) with the supplementation of vitamins (A, B2, B12, C, and E) and carotene. This study provided the new insights to reveal the toxic mechanism of PCNs on human endocrine systems and the recommendations on nutritional supplements for health risk reduction. The methodology and findings could serve as valuable references for screening of potential endocrine disruptors and developing appropriate strategies for PCN or other persistent organic pollution control and health risk management.Memorial University Open Access Author's Fun
The Case Study of Crisis Practice Experience \ue2 The Conflict for Taiwan Power Company Build Distribution Substation
No full textTaiwan Power Company has been facing the crises of demonstration whenever they plan to build a new transformer station. The process of dealing with this problem is tough and usually takes a long while. This study is to discuss some cases and communicative strategies that Taiwan Power Company has used to deal with the demonstration which the public protest against transformer stations. Through the process of solving the problem, they have learned to use public relation to approach the public, solve crises, overcome the difficulties, and eventually build their transformer stations to keep providing the public quality electricity.
Based on the previous documentation and researches, this study covers the topics such as \ue2not in my back yard (NIMBY)\ue2 to \ue2yes in my back yard \ue2(YIMBY)\ue2, how to build public relations and business image, the communication tools of handling crisis, and a case in Japan detailed how the power company handled and communicated with the public when building a transformer station. We are hoping that we can set up an example of crisis handling for Taiwan Power Company in the future through above topics.
The study method and subjects are based on the management activity by phases and aimed at the communication method of public relation and business image. To make this study more detailed and thorough, the selected cases are from where the author works at which include the cases in Xiaying, Tainan, Jiaxian, Kaohsiung, Neiwei, Kaohsiung and Longzi Kaohsiung. In addition, we include some of the related issues from similar cases in Dafon, Taipei, Qielao Chunghua, Nongyi, Pingtung in this study. We studied the whole process starting from the public demonstration to how the Power Company handled the protest and made the public\ue2s worries go away, then made the public from \ue2NIMBY\ue2 to \ue2YIMBY\ue2 and eventually built the transformer stations without obstacles.
In the end of this study, we discuss about what Taiwan Power Company has learned from the successful cases through the process of handling crises from public\ue2s demonstration such as \ue2turning enemies into friends and creating win-win situation\ue2. It fits the key concepts of Taiwan Power Company which are \ue2sincerity, care, creativity, service\ue2, \ue2overcoming the difficulty, sincerely communicating, resolving crisis\ue2, and \ue2Taiwan Power Company team was able to bring their wisdoms and efforts into the matter\ue2. In the future, Taiwan Power Company should try to apply the idea of environment protection and energy saving into the community when they plan to build a transformer station so that they can gain people\ue2s approval without encountering protests. For example, the Power Company made a green space open to the community when they built Dafon Taipei transformer station; Chi-chuan Li built a gazebo with the indemnity from Power Company when they built the transformer station in Qie-Lao Chung-hua. Taiwan Power Company also built an energy saving transformer station in Nongyi. These are very successful cases that Taiwan Power Company made the crises of protests go away
Eutetrapha cinnabarina Pu 1986
No full textEutetrapha cinnabarina Pu, 1986 Figs. 74–86 Eutetrapha cinnabarina Pu, 1986: 201, 202, fig. 1. Type locality: China, Hubei, Shennongjia, Hongpinglinchang. Type depository: IZAS. Eutetrapha cinnabarina; Pu & Jin, 1991: 190; Hua, 2002: 208; Hua et al., 2009: 455; Löbl & Smetana, 2010: 323; Lin, 2015: 274, fig. 217581, 217582. Supplementary description. Black spots in dorsal view lack pubescence, indicating a highly variable character, because pubescence can be rubbed off in many different ways. According to our observations, three spots on occiput and six spots on basal half of elytra are more or less stable in quantity, though size and shape are variable, while pronotal black spots are variable among four separated rounded spots (Figs. 75, 76, 79, 80) to two longitudinal stripes (Figs. 74, 77, 78), and black spots on apical half of elytra variable among one large patch (Figs. 74, 77), five to eight separated spots (Figs. 75, 76, 78–80). Male genitalia (Figs. 81–85): Tergite VIII (Figs. 81 a, 81c) as broad as long, apex emarginate at middle, with setae which are long at sides, shorter and sparser at middle. Spiculum gastrale slightly shorter than ringed part of tegmen, spiculum relictum about a half-length of spiculum gastrale. Tegmen (Figs. 82 a, 82c, 82d) length about 2.9 mm; lateral lobes slender, each about 0.8 mm long and 0.2 mm wide (Fig. 82 d); apex with fine setae which are shorter than half of lateral lobes; median lobe slightly curved (Figs. 82 b, 85) in lateral view, shorter than tegmen; median struts shorter than half-length of median lobe; apex of ventral plate (Fig. 82 a) pointed; endophallus nearly four times as long as median lobe, with two pairs of basal platelike sclerites (located behind apex of median struts), two bands of indistinct supporting armature, and three rod-like sclerites at end (Fig. 83), two longer ones each about 2.5 mm, shorter than tegmen, short one about 2.2 mm. Female genitalia: spermathecal capsule (Fig. 86) composed of an apical orb and a short and strongly curved stalk. Spiculum ventrale slightly longer than abdomen. In our observation, spiculum ventrale measured 8.5 mm for an adult compared with abdomen which measured 8.0 mm in ventral view. Diagnosis. This species is similar to E. elegans Hayashi, 1966 from Taiwan, but can be separated by the elytron lacking a black spot between the middle spot and the first spot just after scutellum. The appendiculate tooth of claws of pro- and mesotarsi are more developed (four males of E. elegans Hayashi, 1966 had been observed). The black spots before elytra apex are variable in shape and quantity in both species, which is not a good diagnostic character. Remarks. One photograph was reported by Wang (2014: 722, fig. 3418+1) from Guangxi, but the locality should be wrong. This species doesn’t distribute in Guangxi. Gansu and Shandong were reported by Wang (2014: 722, fig. 3419 and fig. 3419+1) as E. elegans, which were obviously E. cinnabarina and the localities could be correct. Distribution. China: Hebei (new province record), Henan (new province record), Shaanxi (new province record), Hubei, Gansu, Shandong. Type specimens examined. Holotype, male (Fig. 74), Hubei, Shennongjia [31°26'N, 110°16'E], Hongpinglinchang, alt. 1660 m, 1981. VII.19, leg. Yin-Heng Han (IZAS, IOZ (E) 217581); allotype, female, Hubei, Shennongjia, Jiuhulinchang, alt. 1640 m, 1981. VII.8, leg. Yin-Heng Han (IZAS, IOZ (E) 217582). Other specimens examined. Shaanxi: 1 female, Ankangshi, Ningshan County, Guanghuojiezhen, alt. 1227 m, 33.779527°N, 108.790894°E, 2014. VII.26, leg. Yuan-Yuan Lu by light trap (IZAS, Ceram-218); 1 female, Qinling, Huoditang, 2012. VI.30, YQ09-G1 (BJFU); 1 male (Fig. 77), Ningshan, Huoditang, 1580–1650 m, 1999. VI.26, leg. De-Cheng Yuan (IZAS); 1 male (Fig. 79), Ningshan, Huoditang, 1580 m, 1998. VII.27, leg. De- Cheng Yuan (IZAS), 1 male (Fig. 78) 1 female, same data but 1998. VIII.14, leg De-Cheng Yuan by light trap (IZAS); 2 females, Ningshan, 2003.VIII, leg. Song-Yun Lang (IZAS, ex Collection of Song-Yun Lang); 1 male 1 female, Zhouzhi, Houzhenzi, 1350 m, 1999.VI.21,24, leg. Jian Yao, You-Wei Zhang (IZAS); 1 female (Fig. 75), Zhouzhi County, Houzhenzi, Qinlingliang, 2021 m, 33.81491°N, 107.74357°E, 2007. V.27, leg. Mei-Ying Lin (IZAS); 1 male, Liuba, Miaotaizi, 1350 m, 1998. VII.21, leg. Jian Yao (IZAS); 1 female, Qinling Mts., S. slope, Xunyangba - S+W env., 33°28–37'N, 108°23–33'E, 1400–2100 m, 1995. VI.5–9, leg. L. & R. Businský (CCH, examined by Carolus Holzschuh). Hebei: 1 male (Fig. 76), Chengde City, Xinglong County, Wulingshan, 2008. VII.15, leg. C. Wu (CCCC); 2 male, Fengning, Dengzhazi, 1999. VII.13, leg Ming Bai (HBU); 2 females, Fengning, Dengzhazilinchang, 2000. VII.20, leg. Ai-Min Shi etc (HBU). Henan: 1 male (Fig. 80), Songxian, Baiyunshan, 1600 m, 2002. VII.25, leg. Li-Jie Zhang (IZAS). Hubei: 1 female, W-Hubei, Dashennongjia massif - E slope, 31°24–30'N, 110°21–24'E, 1300–2000 m, 1995. VI.28–VII.5, leg. L.+ R. Businský (CCH, examined by Carolus Holzschuh). One special and doubtful sample: 1 female, Tianjin, Jixian, Xiaying, Huanghuashan, 2008. V.25, leg. Shi-Chun Chen (CCCC). This specimen has the black spot between the middle spot and the first spot just after scutellum.Published as part of Lin, Mei-Ying, Bi, Wen-Xuan & Yang, Xing-Ke, 2017, A revision of the genus Eutetrapha Bates (Coleoptera: Cerambycidae: Lamiinae: Saperdini), pp. 151-202 in Zootaxa 4238 (2) on pages 175-177, DOI: 10.11646/zootaxa.4238.2.1, http://zenodo.org/record/34519
Correction: Prostate cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly
No full textMOESM1 of Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly
No full textAdditional file 1: Figure S1. The mRNA and protein expression of SPOP/Caprin1 in prostate cancer cells. Figure S2. Validation of SPOP/Caprin1 knockout in C4–2 cells. Figure S3. The SBC motif in Caprin1 is a degron recognized by SPOP. Figure S4. SPOP-ΔNLS mutant is constitutively localized in cytoplasm as puncta and more potent in promote Caprin1 degradation than wildtype SPOP-WT. Figure S5. SPOP knockout enhanced AS-induced SGs assembly in C4–2 cells. Figure S6. SPOP knockout enhances, while Carpin1 knockout suppresses Docetaxel-induced stress granules assembly in C4–2 cells. Figure S7. SPOP had no impact on clotrimazole-induced SG assembly. Figure S8. SPOP is dispensable for stress-induced translational arrest. Figure S9. SPOP had no impact on P-bodies assembly. Figure S10. Knockout or overexpression of Caprin1 marginally affected the growth or migration, but significantly increased stress-induced cell death in C4–2 cells. Figure S11. Validation of anti-Caprin1 antibody for IHC through using parental and Caprin1 knockout cells
MOESM2 of Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly
No full textAdditional file 2: Table S1. Primers, sequences of shRNAs and siRNAs, antibody and chemicals. Table S2. SPOP mutation status, Caprin1 IHC scores in 131 cases of prostate cancer specimens and the associated clinical information. Table S3. Primers, sequences of shRNAs and siRNAs, antibody and chemicals
