2,462 research outputs found
Supplemental material for Integrated telerehabilitation approach in multiple sclerosis: A systematic review and meta-analysis
No full textSupplemental Material for Integrated telerehabilitation approach in multiple sclerosis: A systematic review and meta-analysis by Sonia Di Tella, Chiara Pagliari, Valeria Blasi, Laura Mendozzi, Marco Rovaris and Francesca Baglio in Journal of Telemedicine and Telecare</p
Editorial: When (and How) Is Theory of Mind Useful? Evidence from Life-Span Research
No full text[No abstract available
Impact of Anatomical Variability on Sensitivity Profile in fNIRS–MRI Integration
No full textFunctional near-infrared spectroscopy (fNIRS) is an important non-invasive technique used to monitor cortical activity. However, a varying sensitivity of surface channels vs. cortical structures may suggest integrating the fNIRS with the subject-specific anatomy (SSA) obtained from routine MRI. Actual processing tools permit the computation of the SSA forward problem (i.e., cortex to channel sensitivity) and next, a regularized solution of the inverse problem to map the fNIRS signals onto the cortex. The focus of this study is on the analysis of the forward problem to quantify the effect of inter-subject variability. Thirteen young adults (six males, seven females, age 29.3 ± 4.3) underwent both an MRI scan and a motor grasping task with a continuous wave fNIRS system of 102 measurement channels with optodes placed according to a 10/5 system. The fNIRS sensitivity profile was estimated using Monte Carlo simulations on each SSA and on three major atlases (i.e., Colin27, ICBM152 and FSAverage) for comparison. In each SSA, the average sensitivity curves were obtained by aligning the 102 channels and segmenting them by depth quartiles. The first quartile (depth < 11.8 (0.7) mm, median (IQR)) covered 0.391 (0.087)% of the total sensitivity profile, while the second one (depth < 13.6 (0.7) mm) covered 0.292 (0.009)%, hence indicating that about 70% of the signal was from the gyri. The sensitivity bell-shape was broad in the source–detector direction (20.953 (5.379) mm FWHM, first depth quartile) and steeper in the transversal one (6.082 (2.086) mm). The sensitivity of channels vs. different cortical areas based on SSA were analyzed finding high dispersions among subjects and large differences with atlas-based evaluations. Moreover, the inverse cortical mapping for the grasping task showed differences between SSA and atlas based solutions. In conclusion, integration with MRI SSA can significantly improve fNIRS interpretation
The 36-Item Yoni Task: Normative Data for the Clinical Assessment of Theory of Mind
No full textBackground: The evaluation of Theory of Mind (ToM) in the clinical setting remains limited due to the lack of valid instruments for a quick and reliable assessment. In this study, the psychometric properties of the Yoni-36 task were tested, and correction grids, equivalence scores, and normative data were computed. Methods: In total, 318 healthy subjects (169 females; mean age = 42.22 ± 18.11 years; mean education = 15.01 ± 3.43 years) were enrolled and administered the Yoni-36 task. Results: Statistical analysis showed good-to-high internal consistency, split-half reliability, and discrimination ability (especially for the second-order items) of the Yoni-36 task. Regression models highlighted the predictive role of age and education on second-order, affective, cognitive accuracy, and response time scores. Education influenced the first-order ToM response time score as well. Based on β values of the regressions, raw scores of the Yoni task were adjusted for sex, age, and education, and correction grids were computed. The equivalent scores indicated an accuracy index score < 0.69 and a response time index score < 0.83 as cut-off points for ToM competence. Normative data reported a mean accuracy and response time index score of 0.90 ± 0.11 and 0.91 ± 0.05 in the Italian population, respectively. Conclusions: The Yoni-36 proved to be a valid instrument for a quick and reliable ToM assessment, suitable to be included in neuropsychological batteries and to be used in routine clinical practice
sj-docx-1-dhj-10.1177_20552076241228928 - Supplemental material for Efficacy of telerehabilitation with digital and robotic tools for the continuity of care of people with chronic neurological disorders: The TELENEURO@REHAB protocol for a randomized controlled trial
No full textSupplemental material, sj-docx-1-dhj-10.1177_20552076241228928 for Efficacy of telerehabilitation with digital and robotic tools for the continuity of care of people with chronic neurological disorders: The TELENEURO@REHAB protocol for a randomized controlled trial by Federica Rossetto, Fabiola Giovanna Mestanza Mattos, Elisa Gervasoni, Marco Germanotta, Arianna Pavan, Davide Cattaneo, Irene Aprile and Francesca Baglio in DIGITAL HEALTH</p
supplementary – Supplemental material for Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson’s disease
No full textSupplemental material, supplementary for Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson’s disease by Laura Pelizzari, Maria Marcella Laganà, Federica Rossetto, Niels Bergsland, Mirco Galli, Giuseppe Baselli, Mario Clerici, Raffaello Nemni and Francesca Baglio in Therapeutic Advances in Neurological Disorders</p
Abnormal cortical and thalamic development in children with Borderline Intellectual Functioning
No full textsj-docx-1-msj-10.1177_13524585241230236 – Supplemental material for Eye movement desensitization and reprocessing for depressed individuals with multiple sclerosis: A pilot study
No full textSupplemental material, sj-docx-1-msj-10.1177_13524585241230236 for Eye movement desensitization and reprocessing for depressed individuals with multiple sclerosis: A pilot study by Marco Rovaris, Elena Toselli, Laura Mendozzi, Sonia Di Tella, Alice Pirastru, Valeria Blasi, Francesca Baglio, Luca Ostacoli, Alessandra D’Abramo, Alessia Incerti, Isabel Fernandez, Francesco Pagnini and Cesare Cavalera in Multiple Sclerosis Journal</p
A fast and effecctive strategy for artifact identification and signal restoring with HARDI data
No full textThe impact of emotional valence and stimulus habituation on fMRI signal reliability during emotion generation
No full textBackground: The emotional domain is often impaired across many neurological diseases, for this reason it represents a relevant target of rehabilitation interventions. Functional changes in neural activity related to treatment can be assessed with functional MRI (fMRI) using emotion-generation tasks in longitudinal settings. Previous studies demonstrated that within-subject fMRI signal reliability can be affected by several factors such as repetition suppression, type of task and brain anatomy. However, the differential role of repetition suppression and emotional valence of the stimuli on the fMRI signal reliability and reproducibility during an emotion-generation task involving the vision of emotional pictures is yet to be determined.Methods: Sixty-two healthy subjects were enrolled and split into two groups: group A (21 subjects, test-retest reliability on same-day and with same-task-form), group B (30 subjects, test-retest reproducibility with 4-month-interval using two equivalent-parallel forms of the task). Test-retest reliability and reproducibility of fMRI responses and patterns were evaluated separately for positive and negative emotional valence conditions in both groups. The analyses were performed voxel-wise, using the general linear model (GLM), and via a region-of-interest (ROI)-based approach, by computing the intra-class correlation coefficient (ICC) on the obtained contrasts.Results: The voxel-wise GLM test yielded no significant differences for both conditions in reliability and repro-ducibility analyses. As to the ROI-based approach, across all areas with significant main effects of the stimuli, the reliability, as measured with ICC, was poor (<0.4) for the positive condition and ranged from poor to excellent (0.4-0.75) for the negative condition. The ICC-based reproducibility analysis, related to the comparison of two different parallel forms, yielded similar results.Discussion: The voxel-wise GLM analysis failed to capture the poor reliability of fMRI signal which was instead highlighted using the ROI-based ICC analysis. The latter showed higher signal reliability for negative valence stimuli with respect to positive ones. The implementation of two parallel forms allowed to exclude neural suppression as the predominant effect causing low signal reliability, which could be instead ascribed to the employment of different neural strategies to cope with emotional stimuli over time. This is an invaluable in-formation for a better assessment of treatment and rehabilitation effects in longitudinal studies of emotional neural processing
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