196,166 research outputs found
Electrostatic and non-electrostatic contributions to the binding free energies of anthracycline antibiotics to DNA
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Evidence for extreme fractionation of peralkaline silicic magmas, the Boseti volcanic complex, Main Ethiopian Rift
Get PDFMatrix glass and melt inclusions in phenocrysts from pantellerite lavas of the Boseti volcanic complex, Ethiopia, record extreme fractionation of peralkaline silicic magma, with Al 2O 3 contents as low as 2.3 wt.%, FeO* contents up to 17 wt.% and SiO 2 contents ~65 wt.%. The new data, and published data for natural and experimental glasses, suggest that the effective minimum composition for peralkaline silicic magmas has ~5 wt.% Al 2O 3, 13 wt.% FeO* and 66 ± 2 wt.% SiO 2. The dominant fractionating assemblage is alkali feldspar + fayalite + hedenbergite + oxides ± quartz. Feldspar - melt relationships indicate that the feldspar is close to the minimum on the albite-orthoclase solid solution loop through the entire crystallization history. There is petrographic, mineralogical and geochemical evidence that magma mixing may have been a common process in the Boseti rhyolites. © 2011 The Author(s)
MM/PBSA analysis of molecular dynamics simulations of bovine b-lactoglobulin: free energy gradients in conformational transitions?
No full textThe pH-driven opening and closure of -lactoglobulin EF loop, acting as a lid and closing the internal cavity of the protein, has been studied by molecular dynamics (MD) simulations and free energy calculations based on molecular mechanics/Poisson-Boltzmann (PB) solvent-accessible surface area (MM/PBSA) methodology. The forms above and below the transition pH differ presumably only in the protonation state of residue Glu89. MM/PBSA calculations are able to reproduce qualitatively the thermodynamics of the transition. The analysis of MD simulations using a combination of MM/PBSA methodology and the colony energy approach is able to highlight the driving forces implied in the transition. The analysis suggests that global rearrangements take place before the equilibrium local conformation is reached. This conclusion may bear general relevance to conformational transitions in all lipocalins and proteins in general
MM/PBSA Analysis of Molecular Dynamics Simulations of Bovine beta-Lactoglobulin: Free Energy Gradient in Conformational Transitions?
No full textDr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
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